Cited by 180Systemic Lupus Erythematosus ResearchReproductive System and PregnancyBlood Coagulation and Thrombosis Mechanisms

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First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss

Bramham, Kate, Thomas, Mari, Nelson-Piercy, Catherine, Khamashta, Munther, Hunt, Beverley J.·2011·Blood

DOI 10.1182/blood-2011-02-339234

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Abstract

The objective of this study was to assess pregnancy outcome in women with a history of refractory antiphospholipid antibody-associated pregnancy loss(es) who were treated with early low-dose prednisolone in addition to aspirin and heparin. Eighteen women with antiphospholipid antibodies who had refractory pregnancy loss(es) were given prednisolone (10 mg) from the time of their positive pregnancy test to 14 weeks' gestation. Before low-dose prednisolone was given as treatment, 4 (4%) of 97 pregnancies had resulted in live births. Among 23 pregnancies supplemented with prednisolone, 9 women had 14 live births (61%), including 8 uncomplicated pregnancies. The remainder were complicated by preterm delivery, preeclampsia, and/or small-for-gestational-age infants. There were 8 first-trimester miscarriages and 1 ectopic pregnancy. There were no fetal deaths after 10 weeks' gestation and no evidence of maternal morbidity. The addition of first-trimester low-dose prednisolone to conventional treatment is worthy of further assessment in the management of refractory antiphospholipid antibody-related pregnancy loss(es), although complications remain elevated.

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Authors: Bramham, K., Thomas, M., Nelson-Piercy, C., Khamashta, M., & Hunt, B. J.
Affiliations: King's College London (GB)
National Health Service (GB)
Obstetric Medicine, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom;
Guy's and St Thomas' NHS Foundation Trust (GB)
Corresponding author: Bramham, Kate
Thomas, Mari
ORCID: Bramham, Kate
Thomas, Mari
Khamashta, Munther
Hunt, Beverley J.
Venue: Blood
Publisher: American Society of Hematology
Published: 2011-06-23
Volume: 117
Issue: 25
Pages: 6948-6951
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2011-02-339234
OpenAlex: W2049326681
Cited by: 180
References: 27
Citations by year: 2026: 4 · 2025: 4 · 2024: 13 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 19 · 2018: 12 · 2017: 13 · 2016: 17 · 2015: 15 · 2014: 15 · 2013: 10 · 2012: 6
FWCI: 8.42
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institute for Health and Care Research (DRF-2009-02-18)
British Heart Foundation (FS/10/013/28073)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: antiphospholipid antibodies, miscarriage, low-dose prednisolone, aspirin, heparin, pregnancy outcomes, ectopic pregnancy, preterm birth, preeclampsia, small for gestational age
MeSH terms: Abortion, Spontaneous, Adult, Anti-Inflammatory Agents, Anticoagulants, Aspirin, Female, Heparin, Humans, Prednisolone, Pregnancy, Pregnancy Trimester, First, Antiphospholipid Syndrome, Antibodies, Antiphospholipid

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First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss

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