The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: data from a European multicenter retrospective study
Abstract
In European multicenter study, we aimed to describe the real-life hydroxychloroquine use in APS patients during pregnancy and determine its benefit in refractory obstetrical APS. We analyzed the outcome of pregnancies treated by hydroxychloroquine in patients with APS or asymptomatic antiphospholipid (aPL) antibodies carriers. Thirty patients with APS with 35 pregnancies treated by hydroxychloroquine were analyzed. Comparing the outcome of pregnancies treated by the addition of hydroxychloroquine to previous pregnancies under the conventional treatment, pregnancy losses decreased from 81% to 19% (p<0.05), without differences in the associated treatments. The univariate analysis showed that the previous intrauterine deaths and higher hydroxychloroquine amount (400mg per day) were the factors associated with pregnancy outcome. Considering 14 patients with previous refractory obstetrical APS (n=5 with obstetrical and thrombotic primary APS and n=9 with purely obstetrical APS), all with previous pregnancy losses under treatment (aspirin with LMWH in 11 cases and LMWH in 3 cases), the addition of hydroxychloroquine resulted in live born babies in 11/14 (78%) cases (p<0.05). Our study shows the benefit of hydroxychloroquine addition in patients with refractory obstetrical APS and raises the need of prospective studies to confirm our preliminary study.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Evidence directly supporting the addition of HCQ or low-dose prednisolone in the first trimester is based on two small observational studies with limited representativeness.
“Evidence directly supporting these treatment options is based on two small observational studies with limited representativeness.56 57”
From EULAR recommendations for the management of antiphospholipid syndrome in adults (2019) · cites this paper as [56]
Cites
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Self-citationRuiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 864 · see citing works
Lockshin, M. D., Kim, M., Laskin, C. A., Guerra, M., Branch, D. W., Merrill, J., Petri, M., Porter, T. F., Sammaritano, L., Stephenson, M. D., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34402 · Cited by 388 · see citing works
Erkan, D., Aguiar, C. L., ANDRADE, D. C. O. D., Cohen, H., Cuadrado, M. J., Danowski, A., Levy, R. A., Ortel, T. L., Rahman, A., Salmon, J. E., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.053 · Cited by 317 · see citing works
Alijotas‐Reig, J., Esteve‐Valverde, E., Ferrer‐Oliveras, R., Comet, L. S., Lefkou, E. E., MEKINIAN, A., Belizna, C. C., Ruffatti, A., Tincani, A., Marozio, L., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.12.006 · Cited by 215 · see citing works
Self-citationRuffatti, A., Tonello, M., Visentin, M. S., Bontadi, A., Hoxha, A., Carolis, S. D., Botta, A., Salvi, S., Nuzzo, M. D., Rovere, P. Q., et al. (2011) · Rheumatology · doi:10.1093/rheumatology/ker139 · Cited by 214 · see citing works
Self-citationPregnancy outcome in different clinical phenotypes of antiphospholipid syndrome
Bramham, K., Hunt, B., Germain, S., Calatayud, I., Khamashta, M., Bewley, S., & Nelson-Piercy, C. (2010) · Lupus · doi:10.1177/0961203309347794 · Cited by 185 · see citing works
First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss
Bramham, K., Thomas, M., Nelson-Piercy, C., Khamashta, M., & Hunt, B. J. (2011) · Blood · doi:10.1182/blood-2011-02-339234 · Cited by 180 · see citing works
Alijotas‐Reig, J., Ferrer‐Oliveras, R., Ruffatti, A., Tincani, A., Lefkou, E. E., Bertero, M. T., Coloma, E., Carolis, S. D., Espinosa, G., Rovere, P. Q., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.12.010 · Cited by 152 · see citing works
Self-citationAntithrombotic effects of hydroxychloroquine in primary antiphospholipid syndrome patients
Schmidt‐Tanguy, A., Voswinkel, J., Henrion, D., Subra, J. F., Loufrani, L., Rohmer, V., Ifrah, N., & Belizna, C. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12363 · Cited by 132 · see citing works
Ruffatti, A., Calligaro, A., Hoxha, A., Trevisanuto, D., Ruffatti, A., Gervasi, M. T., Cuffaro, S., Pengo, V., & Punzi, L. (2010) · Arthritis Care & Research · doi:10.1002/acr.20098 · Cited by 114 · see citing works
Self-citationSalvan, E., Ross, T. D., Gerosa, M., Andreoli, L., Maina, A., Alijotas-Reig, J., Carolis, S. D., Mekinian, A., Bertero, M. T., Canti, V., et al. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-03-0191 · Cited by 108 · see citing works
Self-citationEuropean registry of babies born to mothers with antiphospholipid syndrome
MEKINIAN, A., Lachassinne, E., Nicaise‐Roland, P., Carbillon, L., Motta, M., Vicaut, É., Boinot, C., Avčin, T., Toumelin, P. L., Carolis, S. D., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201167 · Cited by 105 · see citing works
Self-citationHydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies
Marchetti, T., Ruffatti, A., Wuillemin, C., de Moerloose, P., & Cohen, M. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12570 · Cited by 91 · see citing works
Self-citationAlbert, C. R., Schlesinger, W. J., Viall, C. A., Mulla, M. J., Brosens, J. J., Chamley, L., & Abrahams, V. M. (2013) · American Journal of Reproductive Immunology · doi:10.1111/aji.12184 · Cited by 87 · see citing works
Wu, X.-X., Guller, S. M., & Rand, J. H. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.06.064 · Cited by 84 · see citing works
Obstetrical APS: Is there a place for hydroxychloroquine to improve the pregnancy outcome?
MEKINIAN, A., Costedoat-Chalumeau, N., MASSEAU, A., Tincani, A., Caroli, S. D., Alijotas‐Reig, J., Ruffatti, A., Ambrožič, A., Botta, A., Guern, V. L., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.08.040 · Cited by 73 · see citing works
Self-citationAlijotas‐Reig, J. (2012) · Lupus · doi:10.1177/0961203312465782 · Cited by 69 · see citing works
Self-citationAntiphospholipid syndrome: From pathogenesis to novel immunomodulatory therapies
Comarmond, C., & Cacoub, P. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.12.006 · Cited by 69 · see citing works
Ruffatti, A., Marson, P., Pengo, V., Favarò, M., Tonello, M., Bortolati, M., Minucci, D., & Silvestro, G. D. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.11.002 · Cited by 66 · see citing works
Self-citationAlijotas‐Reig, J., & Ferrer‐Oliveras, R. (2012) · Lupus · doi:10.1177/0961203312440058 · Cited by 64 · see citing works
Self-citationAPS ACTION – AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking
Erkan, D., & Lockshin, M. (2012) · Lupus · doi:10.1177/0961203312437810 · Cited by 61 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
EULAR recommendations for the management of antiphospholipid syndrome in adults
Tektonidou, M. G., Andreoli, L., Limper, M., Amoura, Z., Cervera, R., Costedoat-Chalumeau, N., Cuadrado, M. J., Dörner, T., Ferrer-Oliveras, R., Hambly, K., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215213 · Cited by 1,261 · see citing works
Self-citationAndréoli, L., Bertsias, G. K., Agmon‐Levin, N., Brown, S., Cervera, R., Costedoat-Chalumeau, N., Doria, A., Fischer‐Betz, R., Förger, F., Moraes‐Fontes, M. F., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209770 · Cited by 946 · see citing works
Self-citationSchreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 437 · see citing works
Plantone, D., & Koudriavtseva, T. (2018) · Clinical Drug Investigation · doi:10.1007/s40261-018-0656-y · Cited by 305 · see citing works
Russell, M., Dey, M., Flint, J., Davie, P., Allen, A., Crossley, A., Frishman, M., Gayed, M., Hodson, K. K., Khamashta, M. A., et al. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac551 · Cited by 237 · see citing works
Sciascia, S., Hunt, B. J., Talavera-García, E., Lliso-Ribera, G., Khamashta, M. A., & Cuadrado, M. J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.078 · Cited by 201 · see citing works
Sammaritano, L. R. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101463 · Cited by 201 · see citing works
MEKINIAN, A., Cohen, J., Alijotas‐Reig, J., Carbillon, L., Nicaise‐Roland, P., Kayem, G., Daraï, É., Fain, O., & Bornes, M. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12493 · Cited by 176 · see citing works
Self-citationHydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy
Petri, M., Elkhalifa, M., Li, J., Magder, L. S., & Goldman, D. W. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41121 · Cited by 143 · see citing works
Female Infertility and Serum Auto-antibodies: a Systematic Review
Deroux, A., Dumestre‐Pérard, C., Dunand-Faure, C., Bouillet, L., & Hoffmann, P. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8586-z · Cited by 136 · see citing works
Schreiber, K. I., Breen, K. A., Cohen, H., Jacobsen, S., Middeldorp, S., Pavord, S. R., Regan, L., Roccatello, D., Robinson, S. E., Sciascia, S., et al. (2017) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0037-1603359 · Cited by 128 · see citing works
Pathogenesis and management of antiphospholipid syndrome
Arachchillage, D. J., & Laffan, M. (2017) · British Journal of Haematology · doi:10.1111/bjh.14632 · Cited by 120 · see citing works
Bertolaccini, M. L., Contento, G., Lennen, R. J., Sanna, G., Blower, P. J., Ma, M., Sunassee, K., & Girardi, G. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.04.008 · Cited by 105 · see citing works
Tektonidou, M. G., Andréoli, L., Limper, M., Tincani, A., & Ward, M. M. (2019) · RMD Open · doi:10.1136/rmdopen-2019-000924 · Cited by 99 · see citing works
Self-citationManaging antiphospholipid syndrome in pregnancy
Schreiber, K. I., & Hunt, B. J. (2019) · Thrombosis Research · doi:10.1016/s0049-3848(19)30366-4 · Cited by 96 · see citing works
The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases
Martinez, G. P., Zabaleta, M. E., Giulio, C. D., Charris, J., & Mijares, M. R. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200707132920 · Cited by 95 · see citing works
Immunomodulators in SLE: Clinical evidence and immunologic actions
Durcan, L., & Petri, M. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.06.010 · Cited by 92 · see citing works
Tonello, M., Hoxha, A., Sciascia, S., Cuadrado, M. J., Latino, J. O., Udry, S., Reshetnyak, T. M., Costedoat-Chalumeau, N., Morel, N., Marozio, L., et al. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1632388 · Cited by 89 · see citing works
Self-citationAntiphospholipid syndrome – an update
Linnemann, B. (2018) · VASA · doi:10.1024/0301-1526/a000723 · Cited by 85 · see citing works
Belizna, C. C., Pregnolato, F., Abad, S., Alijotas‐Reig, J., Amital, H., Amoura, Z., Andréoli, L., Andrès, E., Aouba, A., Bilgen, Ş. A., et al. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.05.012 · Cited by 78 · see citing works
Self-citationSciascia, S., Branch, D. W., Levy, R. A., Middeldorp, S., Pavord, S. R., Roccatello, D., Ruiz‐Irastorza, G., Tincani, A., Khamashta, M. A., Schreiber, K. I., et al. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-06-0491 · Cited by 78 · see citing works
Self-citationVelásquez, M., Rojas, M., Abrahams, V. M., Escudero, C., & Cadavid, Á. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01840 · Cited by 81 · see citing works
Giacomelli, R., Afeltra, A., Bartoloni, E., Berardicurti, O., Bombardieri, M., Bortoluzzi, A., Carubbi, F., Caso, F., Cervera, R., Ciccia, F., et al. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102738 · Cited by 78 · see citing works
Self-citationPregnolato, F., Gerosa, M., Raimondo, M. G., Comerio, C., Bartoli, F., Lonati, P. A., Borghi, M. O., Acaia, B., Ossola, M. W., Ferrazzi, E. M., et al. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa203 · Cited by 76 · see citing works
MEKINIAN, A., Alijotas‐Reig, J., Carrat, F., Costedoat-Chalumeau, N., Ruffatti, A., Lazzaroni, M. G., Tabacco, S., Maina, A., MASSEAU, A., Morel, N., et al. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.006 · Cited by 75 · see citing works
Self-citationA comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus
Lazzaroni, M. G., Dall’Ara, F., Fredi, M., Nalli, C., Reggia, R., Lojacono, A., Ramazzotto, F., Zatti, S., Andréoli, L., & Tincani, A. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.06.016 · Cited by 69 · see citing works
Self-citationDelineating the deranged immune system in the antiphospholipid syndrome
van den Hoogen, L. L., van Roon, J. A. G., Radstake, T. R. D. J., Fritsch-Stork, R. D. E., & Derksen, R. H. W. M. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.08.011 · Cited by 66 · see citing works
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach
Chighizola, C. B., Andréoli, L., Gerosa, M., Tincani, A., Ruffatti, A., & Meroni, P. L. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.02.003 · Cited by 66 · see citing works
Self-citationGarmendia, J. V., Sanctis, C. V. D., Hajdúch, M., & Sanctis, J. B. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031295 · Cited by 68 · see citing works
MEKINIAN, A., Bourrienne, M., Carbillon, L., Benbara, A., Abisror, N., Chollet‐Martin, S., Tigaizin, A., Montestruc, F., Fain, O., & Nicaise‐Roland, P. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.05.006 · Cited by 59 · see citing works
Self-citationAn update on the management of antiphospholipid syndrome
Rodziewicz, M., & D’Cruz, D. P. (2020) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x20910855 · Cited by 59 · see citing works
Schreiber, K. I., Breen, K. A., Parmar, K., Rand, J. H., Wu, X.-X., & Hunt, B. J. (2017) · Rheumatology · doi:10.1093/rheumatology/kex378 · Cited by 55 · see citing works
Current insights in obstetric antiphospholipid syndrome
Schreiber, K. I., Radin, M., & Sciascia, S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000406 · Cited by 53 · see citing works
Pregnancy outcomes in patients with primary antiphospholipid syndrome
Liu, L., & Sun, D. (2019) · Medicine · doi:10.1097/md.0000000000015733 · Cited by 53 · see citing works
Hydroxychloroquine as an Immunomodulatory and Antithrombotic Treatment in Antiphospholipid Syndrome
Arachchillage, D. J., Laffan, M., & Pericleous, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021331 · Cited by 53 · see citing works
Fredi, M., Andréoli, L., Aggogeri, E., Bettiga, E., Lazzaroni, M. G., Guern, V. L., Lojacono, A., Morel, N., Piette, J. C., Zatti, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00864 · Cited by 50 · see citing works
Self-citationAntiphospholipid syndrome: state of the art on clinical practice guidelines
Limper, M., Scirè, C. A., Talarico, R., Amoura, Z., Avčin, T., Basile, M., Burmester, G. R., Carli, L., Cervera, R., Costedoat-Chalumeau, N., et al. (2018) · RMD Open · doi:10.1136/rmdopen-2018-000785 · Cited by 50 · see citing works
Self-citationEmerging Therapies in Antiphospholipid Syndrome
ANDRADE, D. C. O. D., & Tektonidou, M. G. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0566-z · Cited by 48 · see citing works
Xourgia, E., & Tektonidou, M. G. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102311 · Cited by 48 · see citing works
Lazzaroni, M. G., Fredi, M., Andréoli, L., Chighizola, C. B., Ross, T. D., Gerosa, M., Kuzenko, A., Raimondo, M.-G., Lojacono, A., Ramazzotto, F., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01948 · Cited by 50 · see citing works
Self-citationMarshall, E., Robertson, M., Kam, S., Penwarden, A., Riga, P., & Davies, N. P. (2020) · Eye · doi:10.1038/s41433-020-1038-2 · Cited by 45 · see citing works
Alijotas‐Reig, J., Esteve‐Valverde, E., Llurba, E., & Gris, J. M. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.02.006 · Cited by 43 · see citing works
Self-citationAntiphospholipid syndrome: an update
Merashli, M., Noureldine, M. H. A., Uthman, I. W., & Khamashta, M. A. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12449 · Cited by 43 · see citing works
Carolis, S. D., Botta, A., Salvi, S., di Pasquo, E., Sordo, G. D., Garufi, C., Lanzone, A., & Carolis, M. P. D. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.04.010 · Cited by 43 · see citing works
Update on the pathogenesis and treatment of the antiphospholipid syndrome
Chighizola, C. B., Raschi, E., Borghi, M. O., & Meroni, P. L. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000200 · Cited by 39 · see citing works
New use for an old treatment: Hydroxychloroquine as a potential treatment for systemic vasculitis
Casian, A., Sangle, S. R., & D’Cruz, D. P. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.016 · Cited by 37 · see citing works
Colla, L., Diena, D., Rossetti, M. M., Manzione, A. M., Marozio, L., Benedetto, C., & Biancone, L. (2018) · Journal of Nephrology · doi:10.1007/s40620-018-0477-3 · Cited by 36 · see citing works
Nalli, C., Lini, D., Andréoli, L., Crisafulli, F., Fredi, M., Lazzaroni, M. G., Bitsadze, V., Calligaro, A., Canti, V., Caporali, R. F., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9060671 · Cited by 36 · see citing works
Self-citationManagement of Systemic Lupus Erythematosus During Pregnancy
Sammaritano, L. R. (2016) · Annual Review of Medicine · doi:10.1146/annurev-med-042915-102658 · Cited by 35 · see citing works
Treatment of antiphospholipid syndrome beyond anticoagulation
Dobrowolski, C., & Erkan, D. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.03.001 · Cited by 35 · see citing works
Saavedra, M. Á., Miranda-Hernández, D. G., Lara‐Mejía, A., Sánchez, A., Morales, S., Reyes, C. V. C., Cruz-Domínguez, M. P., Medina, G., & Jara, L. J. (2020) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13830 · Cited by 34 · see citing works
de Jesús, G. R., Benson, A. E., Chighizola, C. B., Sciascia, S., & Branch, D. W. (2020) · Lupus · doi:10.1177/0961203320954520 · Cited by 35 · see citing works
Pleguezuelo, D. E., Cabrera-Marante, Ó., Abad, M., Rodriguez-Frias, E. A., Naranjo, L., Vázquez, A. F., Villar, O., Gil‐Etayo, F. J., Serrano, M., Pérez‐Rivilla, A., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102094 · Cited by 36 · see citing works
Preeclampsia and the Antiphospholipid Syndrome
Mayer-Pickel, K. I., Nanda, M., Gajić, M., & Cervar-Zivkovic, M. (2023) · Biomedicines · doi:10.3390/biomedicines11082298 · Cited by 33 · see citing works
Pasquier, É., Martin, L. D. S., Marhic, G., Chauleur, C., Bohec, C., Bretelle, F., Lejeune, V., Hannigsberg, J., Plu‐Bureau, G., Cogulet, V., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025649 · Cited by 33 · see citing works
Positive antiphospholipid antibodies: observation or treatment?
Grygiel‐Górniak, B., & Mazurkiewicz, Ł. (2023) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-023-02834-6 · Cited by 32 · see citing works
Treatment of antiphospholipid syndrome
Radin, M., Cecchi, I., Rubini, E., Foddai, S. G., Barinotti, A., Menegatti, E., Roccatello, D., & Sciascia, S. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108597 · Cited by 31 · see citing works
MEKINIAN, A., Vicaut, É., Cohen, J., Bornes, M., Kayem, G., & Fain, O. (2018) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2018.06.008 · Cited by 31 · see citing works
Self-citationManagement of Antiphospholipid Syndrome
Ghembaza, A., & Saadoun, D. (2020) · Biomedicines · doi:10.3390/biomedicines8110508 · Cited by 50 · see citing works
Antiphospholipid syndrome: Diagnosis and management in the obstetric patient
Arslan, E., & Branch, D. W. (2019) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2019.10.001 · Cited by 30 · see citing works
Obstetric antiphospholipid syndrome
Esteve‐Valverde, E., Ferrer‐Oliveras, R., & Alijotas‐Reig, J. (2015) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2015.11.003 · Cited by 29 · see citing works
Self-citationPregnancy and reproductive aspects of systemic lupus erythematosus
Andréoli, L., Crisafulli, F., & Tincani, A. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000415 · Cited by 29 · see citing works
Self-citationSimonin, L., Pasquier, É., Leroyer, C., Cornec, D., Lemerle, J., Bendaoud, B., Hillion, S., Pers, J., Couturaud, F., & Renaudineau, Y. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8568-1 · Cited by 29 · see citing works
Hooper, A., Bacal, V., & Bedaiwy, M. A. (2023) · American Journal of Reproductive Immunology · doi:10.1111/aji.13761 · Cited by 28 · see citing works
Dilemmas in the diagnosis and management of antiphospholipid syndrome
Manning, J. E., & Arachchillage, D. J. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.03.027 · Cited by 30 · see citing works
Update on Antiphospholipid Syndrome: Ten Topics in 2017
Cavazzana, I., Andréoli, L., Limper, M. A., Franceschini, F., & Tincani, A. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0718-4 · Cited by 28 · see citing works
Self-citationImmunosuppressive Treatment in Antiphospholipid Syndrome: Is It Worth It?
Mormile, I., Granata, F., Punziano, A., de Paulis, A., & Rossi, F. W. (2021) · Biomedicines · doi:10.3390/biomedicines9020132 · Cited by 27 · see citing works
Anti‐phospholipid antibodies and reproductive failures
Beltagy, A., Trespìdi, L., Gerosa, M., Ossola, M. W., Meroni, P. L., & Chighizola, C. B. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13258 · Cited by 27 · see citing works
Recognition and management of antiphospholipid syndrome
Gerosa, M., Meroni, P. L., & Erkan, D. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000240 · Cited by 26 · see citing works
Bundhun, P. K., Soogund, M. Z. S., & Huang, F. (2018) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-018-1850-x · Cited by 26 · see citing works
Marshall, E., Robertson, M., Kam, S., Penwarden, A., Riga, P., & Davies, N. P. (2020) · Eye · doi:10.1038/s41433-020-1102-y · Cited by 26 · see citing works
Yang, Z., Shen, X., Zhou, C., Wang, M., Liu, Y., & Zhou, L. (2020) · Lupus · doi:10.1177/0961203320967097 · Cited by 25 · see citing works
Ruffatti, A., Tonello, M., Favarò, M., Ross, T. D., Calligaro, A., Gervasi, M. T., Gervasi, M. T., & Hoxha, A. (2020) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.10.001 · Cited by 25 · see citing works
Self-citationLiu, Y., Wei, Y., Zhang, Y., & Yang, H. (2023) · Clinical Rheumatology · doi:10.1007/s10067-022-06496-2 · Cited by 25 · see citing works
Mayer-Pickel, K. I., Eberhard, K., Lang, U., & Cervar-Zivkovic, M. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8569-0 · Cited by 25 · see citing works
Síndrome antifosfolipídico obstétrico
Esteve‐Valverde, E., Ferrer‐Oliveras, R., & Alijotas‐Reig, J. (2015) · Revista Clínica Española · doi:10.1016/j.rce.2015.09.003 · Cited by 23 · see citing works
Self-citationAntiphospholipid syndrome: an update for clinicians and scientists
Vreede, A. P., Bockenstedt, P. L., & Knight, J. S. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000410 · Cited by 22 · see citing works
Meroni, P. L. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.07.003 · Cited by 22 · see citing works
Additional Treatments for High-Risk Obstetric Antiphospholipid Syndrome: a Comprehensive Review
Ruffatti, A., Hoxha, A., Favarò, M., Tonello, M., Colpo, A., Cucchini, U., Banzato, A., & Pengo, V. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8571-6 · Cited by 21 · see citing works
Self-citationPregnancy in antiphospholipid syndrome: what should a rheumatologist know?
Andréoli, L., Regola, F., Caproli, A., Crisafulli, F., Fredi, M., Lazzaroni, M. G., Nalli, C., Piantoni, S., Zatti, S., Franceschini, F., et al. (2023) · Rheumatology · doi:10.1093/rheumatology/kead537 · Cited by 23 · see citing works
Self-citationManagement of pregnant women with antiphospholipid antibodies
Ruffatti, A., Favarò, M., Calligaro, A., Zambon, A., & Ross, T. D. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1565995 · Cited by 21 · see citing works
Self-citationHow toxic is an old friend? A review of the safety of hydroxychloroquine in clinical practice
Fairley, J. L., Nikpour, M., Mack, H. G., Brosnan, M. J., Saracino, A., Pellegrini, M., & Wicks, I. P. (2022) · Internal Medicine Journal · doi:10.1111/imj.15908 · Cited by 20 · see citing works
Riancho‐Zarrabeitia, L., López-Marín, L., Muñoz, P., López‐Hoyos, M., del Barrio, R., Haya, A., & Martínez-Taboada, V. M. (2022) · Lupus · doi:10.1177/09612033221091401 · Cited by 18 · see citing works
The pathogenesis of obstetric APS: a 2023 update
Mineo, C., Shaul, P. W., & Bermas, B. L. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109745 · Cited by 23 · see citing works
Obstetric anti-phospholipid syndrome: from pathogenesis to treatment
Kaneko, K., Ozawa, N., & Murashima, A. (2021) · Immunological Medicine · doi:10.1080/25785826.2021.1969116 · Cited by 18 · see citing works
Hoxha, A., Tormene, D., Campello, E., & Simioni, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.849692 · Cited by 17 · see citing works
Obstetric Anti-phospholipid Syndrome: State of the Art
Gerardi, M. C., Fernandes, M. A., Tincani, A., & Andréoli, L. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0772-y · Cited by 16 · see citing works
Self-citationWhat’s new in obstetric antiphospholipid syndrome
Branch, D. W. (2019) · Hematology · doi:10.1182/hematology.2019000043 · Cited by 16 · see citing works
Ricard, L., Laurent, C., Papo, M., Deriaz, S., Catano, J., Alamowitch, S., Kayem, G., Chasset, F., MOREUIL, C. D., Boffa, J. J., et al. (2021) · Joint Bone Spine · doi:10.1016/j.jbspin.2021.105297 · Cited by 14 · see citing works
Self-citationZhou, Z., Teng, J., Sun, Y., Liu, H., Cheng, X., Su, Y., Yang, C., & Ye, J. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04670-7 · Cited by 16 · see citing works
Hoxha, A., Favarò, M., Calligaro, A., Ross, T. D., Ruffatti, A. T., Infantolino, C., Tonello, M., Mattia, E., & Ruffatti, A. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1697665 · Cited by 14 · see citing works
Self-citationPrevention of Pregnancy Complications in Antiphospholipid Syndrome
Czwalinna, A., & Bergmann, F. (2020) · Hämostaseologie · doi:10.1055/a-1113-0689 · Cited by 14 · see citing works
Hydroxychloroquine as additional treatment in pregnant patients with refractory APS
Carolis, S. D., Rizzo, F., & Tabacco, S. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.08.113 · Cited by 14 · see citing works
Pregnancy Management in Women with Antiphospholidic Syndrome
Radu, A., Dudu, S. C., Ciobanu, A. M., Peltecu, G. C., Iancu, G., Botezatu, R., Gică, N., & Panaitescu, A. M. (2019) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2019.14.2.148 · Cited by 15 · see citing works
Obstetric antiphospholipid syndrome
Soto-Peleteiro, A., González-Echávarri, C., & Ruiz‐Irastorza, G. (2024) · Medicina Clínica · doi:10.1016/j.medcli.2024.05.001 · Cited by 15 · see citing works
Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia – a Literature Review
Deharde, D., Klockenbusch, W., Schmitz, R., Brand, M., Köster, H. A., & de Murcia, K. O. (2020) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1170-5145 · Cited by 13 · see citing works
Pregnancy outcome in systemic lupus erythematosus patients: a monocentric cohort analysis
Ceccarelli, F., Pirone, C., Perricone, C., Selntigia, A., Orefice, V., Pacucci, V. A., Truglia, S., Spinelli, F. R., Galoppi, P., Alessandri, C., et al. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa470 · Cited by 14 · see citing works
Tian, Y., Xu, J., Chen, D., Yang, C., & Peng, B. (2021) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2021.102121 · Cited by 13 · see citing works
Gajić, M., Schröder‐Heurich, B., & Mayer-Pickel, K. I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1298928 · Cited by 14 · see citing works
Obstetric and perinatal outcomes of pregnancy in patients with repeated implantation failure
Chin, T.-H., Hsu, Y. C., Soong, Y. K., Lee, C. L., Wang, H. S., Huang, H. Y., Wu, H. M., Yu, H. T., Huang, S. Y., & Chang, C. L. (2019) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2019.05.010 · Cited by 12 · see citing works
- Authors
- Mekinian, A., Lazzaroni, M. G., Kuzenko, A., Alijotas-Reig, J., Ruffatti, A., Levy, P., Canti, V., Bremme, K., Bezanahary, H., Bertero, T., Dhote, R., Maurier, F., Andreoli, L., Benbara, A., Tigazin, A., Carbillon, L., Nicaise-Roland, P., Tincani, A., & Fain, O.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- University of Padua (IT)
- IRCCS Ospedale San Raffaele (IT)
- Karolinska Institutet (SE)
- Université Sorbonne Paris Nord (FR)
- ORCID
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 14
- Issue
- 6
- Pages
- 498-502
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W1966792319
- Cited by
- 182
- References
- 22
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 8 · 2022: 16 · 2021: 14 · 2020: 23 · 2019: 21 · 2018: 24 · 2017: 14 · 2016: 20 · 2015: 11
- FWCI
- 19.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- hydroxychloroquine, antiphospholipid syndrome, pregnancy outcomes, miscarriage, antiphospholipid antibodies, low molecular weight heparin, aspirin, live birth, intrauterine fetal death
- MeSH terms
- Female, Humans, Hydroxychloroquine, Pregnancy, Pregnancy Outcome, Retrospective Studies, Multicenter Studies as Topic, Antiphospholipid Syndrome, Antibodies, Antiphospholipid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review