Hemogenic endothelium during development and beyond
Open accessAbstract
During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein.
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Inducible lineage tracing of early hemogenic sites with Cdh5-cre does not account for all hematopoietic cells within the embryo.
“Inducible lineage tracing of early hemogenic sites with Cdh5-cre, however, does not account for all hematopoietic cells within the embryo”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Hirschi, 2012
The “Hemogenic endothelial cells” section describes inducible VE-cadherin lineage tracing of cells labeled in the embryonic AGM. The “Postnatal hemogenic endothelium?” section says embryonically labeled HSCs do not account for all hematopoietic cells generated postnatally, not all hematopoietic cells within the embryo. The claim changes the population to which that finding applies. (LLM, conf=0.88)
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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931 · see citing works
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
Goodell, M. A., Brose, K., Paradis, G. A., Conner, A. N., & Mulligan, R. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1797 · Cited by 2,902 · see citing works
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
Jackson, K. A., Majka, S. M., Wang, H., Pocius, J. S., Hartley, C. J., Majesky, M. W., Entman, M. L., Michael, L. H., Hirschi, K. K., & Goodell, M. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12150 · Cited by 1,960 · see citing works
Self-citationDefinitive Hematopoiesis Is Autonomously Initiated by the AGM Region
Medvinsky, A., & Dzierzak, E. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80165-8 · Cited by 1,548 · see citing works
A common precursor for hematopoietic and endothelial cells
Choi, K., Kennedy, M., Kazarov, A. R., Papadimitriou, J. C., & Keller, G. M. (1998) · Development · doi:10.1242/dev.125.4.725 · Cited by 1,410 · see citing works
Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178 · see citing works
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
Palis, J., Robertson, S. M., Kennedy, M., Wall, C., & Keller, G. M. (1999) · Development · doi:10.1242/dev.126.22.5073 · Cited by 1,050 · see citing works
Blood stem cells emerge from aortic endothelium by a novel type of cell transition
Kissa, K., & Herbomel, P. (2010) · Nature · doi:10.1038/nature08761 · Cited by 961 · see citing works
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Boisset, J.-C., van Cappellen, W. A., Andrieu‐Soler, C., Galjart, N., Dzierzak, E. A., & Robin, C. (2010) · Nature · doi:10.1038/nature08764 · Cited by 951 · see citing works
Development of hematopoietic stem cell activity in the mouse embryo
Müller, A. M., Medvinsky, A., Strouboulis, J., Grosveld, F. G., & Dzierzakt, E. (1994) · Immunity · doi:10.1016/1074-7613(94)90081-7 · Cited by 901 · see citing works
A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis
Shalaby, F., Ho, J., Stanford, W. L., Fischer, K.-D., Schuh, A. C., Schwartz, L., Bernstein, A., & Rossant, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80283-4 · Cited by 897 · see citing works
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells
Hirschi, K. K., Ingram, D. A., & Yöder, M. C. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155960 · Cited by 744 · see citing works
Self-citationHaemangioblast commitment is initiated in the primitive streak of the mouse embryo
Huber, T. L., Kouskoff, V., Fehling, H. J., Palis, J., & Keller, G. M. (2004) · Nature · doi:10.1038/nature03122 · Cited by 697 · see citing works
Fate tracing reveals the endothelial origin of hematopoietic stem cells
Zovein, A. C., Hofmann, J. J., Lynch, M., French, W. J., Turlo, K. A., Yang, Y., Becker, M. S., Zanetta, L., Dejana, E., Gasson, J. C., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.018 · Cited by 691 · see citing works
The Placenta Is a Niche for Hematopoietic Stem Cells
Gekas, C., Dieterlen‐Lièvre, F., Orkin, S. H., & Mikkola, H. K. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.016 · Cited by 664 · see citing works
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
Lancrin, C., Sroczyńska, P., Stephenson, C., Allen, T., Kouskoff, V., & Lacaud, G. (2009) · Nature · doi:10.1038/nature07679 · Cited by 629 · see citing works
North, T. E., Bruijn, M. F. T. R. D., Stacy, T., Talebian, L., Lind, E. F., Robin, C., Binder, M., Dzierzak, E. A., & Speck, N. A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00296-0 · Cited by 583 · see citing works
Cumano, A., Dieterlen‐Lièvre, F., & Godin, I. (1996) · Cell · doi:10.1016/s0092-8674(00)80166-x · Cited by 567 · see citing works
Core-binding factors in haematopoiesis and leukaemia
Speck, N. A., & Gilliland, D. G. (2002) · Nature reviews. Cancer · doi:10.1038/nrc840 · Cited by 563 · see citing works
The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Kopp, H., Avecilla, S. T., Hooper, A. T., & Rafii, S. (2005) · Physiology · doi:10.1152/physiol.00025.2005 · Cited by 554 · see citing works
Fehling, H. J., Lacaud, G., Kubo, A., Kennedy, M., Robertson, S. M., Keller, G. M., & Kouskoff, V. (2003) · Development · doi:10.1242/dev.00589 · Cited by 500 · see citing works
Vascular remodeling of the mouse yolk sac requires hemodynamic force
Lucitti, J. L., Jones, E. A. V., Huang, C., Chen, J., Fraser, S. E., & Dickinson, M. E. (2007) · Development · doi:10.1242/dev.02883 · Cited by 478 · see citing works
Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
Samokhvalov, I. M., Samokhvalova, N. I., & Nishikawa, S. (2007) · Nature · doi:10.1038/nature05725 · Cited by 461 · see citing works
The Murine Placenta Contains Hematopoietic Stem Cells within the Vascular Labyrinth Region
Ottersbach, K., & Dzierzak, E. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.001 · Cited by 446 · see citing works
Embryonic origin of the adult hematopoietic system: advances and questions
Medvinsky, A., Александрович, Р. С., & Taoudi, S. (2011) · Development · doi:10.1242/dev.040998 · Cited by 403 · see citing works
Kinder, S. J., Tsang, T. E., Quinlan, G. A., Hadjantonakis, A., Nagy, A., & Tam, P. (1999) · Development · doi:10.1242/dev.126.21.4691 · Cited by 400 · see citing works
The development in vitro of the blood of the early chick embryo
Murray, P. D. F. (1932) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1932.0070 · Cited by 338 · see citing works
Allsopp, R. C., Morin, G. B., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Blood · doi:10.1182/blood-2002-07-2334 · Cited by 324 · see citing works
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula
Vogeli, K. M., Jin, S., Martin, G. R., & Stainier, D. Y. R. (2006) · Nature · doi:10.1038/nature05045 · Cited by 320 · see citing works
Sánchez, M. J., Holmes, A. M., Miles, C. G., & Dzierzak, E. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80267-8 · Cited by 304 · see citing works
Siminovitch, L., Till, J. E., & McCulloch, E. A. (1964) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030640104 · Cited by 277 · see citing works
Majka, S. M., Jackson, K. A., Kienstra, K. A., Majesky, M. W., Goodell, M. A., & Hirschi, K. K. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16157 · Cited by 260 · see citing works
Self-citationHarrison, D. E., Astle, C. M., & Delaittre, J. A. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.147.5.1526 · Cited by 228 · see citing works
Evidence for novel fate of Flk1+ progenitor: Contribution to muscle lineage
Motoike, T., Markham, D. W., Rossant, J., & Sato, T. N. (2003) · genesis · doi:10.1002/gene.10175 · Cited by 225 · see citing works
Robert‐Moreno, A., Guiu, J., Ruiz‐Herguido, C., López, M. E., Inglés‐Esteve, J., Riera, L., Tipping, A. J., Enver, T., Dzierzak, E. A., Gridley, T., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.113 · Cited by 207 · see citing works
Purton, L. E., Dworkin, S., Olsen, G. H., Walkley, C. R., Fabb, S. A., Collins, S. J., & Chambon, P. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052105 · Cited by 202 · see citing works
DNA Repair Defects in Stem Cell Function and Aging
Park, Y., & Gerson, S. L. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104546 · Cited by 166 · see citing works
Tracing the Progeny of the Aortic Hemangioblast in the Avian Embryo
Jaffredo, T., Gautier, R., Brajeul, V., & Dieterlen‐Lièvre, F. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9799 · Cited by 156 · see citing works
Retinoic acid regulates endothelial cell proliferation during vasculogenesis
Lai, L., Bohnsack, B. L., Niederreither, K., & Hirschi, K. K. (2003) · Development · doi:10.1242/dev.00887 · Cited by 150 · see citing works
Self-citationInitiation of Murine Embryonic Erythropoiesis: A Spatial Analysis
Silver, L., & Palis, J. (1997) · Blood · doi:10.1182/blood.v89.4.1154 · Cited by 138 · see citing works
North, T. E., Stacy, T., Matheny, C., Speck, N. A., & Bruijn, M. F. T. R. D. (2004) · Stem Cells · doi:10.1634/stemcells.22-2-158 · Cited by 133 · see citing works
Bohnsack, B. L., Lai, L., Dollé, P., & Hirschi, K. K. (2004) · Genes & Development · doi:10.1101/gad.1184904 · Cited by 112 · see citing works
Self-citationAllocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo
Kinder, S. J., Loebel, D. A. F., & Tam, P. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00091-3 · Cited by 100 · see citing works
Sabin, F. R. (2002) · Stem Cells and Development · doi:10.1089/152581602753448496 · Cited by 99 · see citing works
Goldie, L. C., Lucitti, J. L., Dickinson, M. E., & Hirschi, K. K. (2008) · Blood · doi:10.1182/blood-2008-02-139055 · Cited by 98 · see citing works
Self-citationPhenotype and hematopoietic potential of side population cells throughout embryonic development
Nadin, B. M., Goodell, M. A., & Hirschi, K. K. (2003) · Blood · doi:10.1182/blood-2003-01-0118 · Cited by 92 · see citing works
Self-citationThe role of angiogenic growth factors in organogenesis
Enrico Crivellato, B. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103214ec · Cited by 68 · see citing works
Li, X., Hu, Z., Jorgenson, M. L., Wingard, J. R., & Slayton, W. B. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.06.009 · Cited by 65 · see citing works
Vascular Potential of Human Pluripotent Stem Cells
Iacobas, I., Vats, A., & Hirschi, K. K. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191601 · Cited by 18 · see citing works
Self-citationBiophysical Regulation of Vascular Differentiation and Assembly
Gerecht, S. (2011) · Biological and medical physics series · doi:10.1007/978-1-4419-7835-6 · Cited by 7 · see citing works
Sills, T., & Hirschi, K. K. (2010) · Biological and medical physics series · doi:10.1007/978-1-4419-7835-6_1 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- North TE, de Bruijn MF, Stacy T, et al. Runx1 ex- pression marks long-term repopulating hemato- poietic stem cells in the midgestation mouse em- bryo. Immunity. 2002;16(5):661-672.
Cited by
Sorted by citations
Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells
Naito, H., Iba, T., & Takakura, N. (2020) · International Immunology · doi:10.1093/intimm/dxaa008 · Cited by 241 · see citing works
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Stanczuk, L., Martínez‐Corral, I., Ulvmar, M. H., Zhang, Y., Laviña, B., Fruttiger, M., Adams, R. H., Saur, D., Betsholtz, C., Ortega, S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.026 · Cited by 238 · see citing works
Single-cell analysis reveals congruence between kidney organoids and human fetal kidney
Combes, A. N., Phipson, B., Zappia, L., Lawlor, K. T., Er, P. X., Oshlack, A., & Little, M. H. (2019) · Genome Medicine · doi:10.1186/s13073-019-0615-0 · Cited by 226 · see citing works
Conversion of adult endothelium to immunocompetent haematopoietic stem cells
Lis, R., Karrasch, C. C., Poulos, M. G., Kunar, B., Redmond, D., Durán, J. G. B., Badwe, C. R., Schachterle, W., Ginsberg, M. D., Xiang, J., et al. (2017) · Nature · doi:10.1038/nature22326 · Cited by 222 · see citing works
ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells
Morita, R., Suzuki, M., Kasahara, H., Shimizu, N., Shichita, T., Sekiya, T., Kimura, A., Sasaki, K., Yasukawa, H., & Yoshimura, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413234112 · Cited by 211 · see citing works
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Boya, P., Codogno, P., & Rodriguez-Muela, N. (2018) · Development · doi:10.1242/dev.146506 · Cited by 197 · see citing works
Vascular Wall Progenitor Cells in Health and Disease
Psaltis, P. J., & Simari, R. D. (2015) · Circulation Research · doi:10.1161/circresaha.116.305368 · Cited by 194 · see citing works
Joseph, C. J., Quach, J., Walkley, C. R., Lane, S., Celso, C. L., & Purton, L. E. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.010 · Cited by 183 · see citing works
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification
Reischauer, S., Stone, O. A., Villasenor, A., Chi, N., Jin, S., Martin, M., Lee, M. T., Fukuda, N., Marass, M., Witty, A. D., et al. (2016) · Nature · doi:10.1038/nature18614 · Cited by 162 · see citing works
Macrophages and cellular immunity in Drosophila melanogaster
Gold, K. S., & Brückner, K. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.010 · Cited by 153 · see citing works
Transcriptional Regulation of Endothelial Cell and Vascular Development
Park, C., Kim, T., & Malik, A. B. (2013) · Circulation Research · doi:10.1161/circresaha.113.301078 · Cited by 140 · see citing works
Pericytes are heterogeneous in their origin within the same tissue
Prazeres, P. H. D. M., Sena, I. F. G., Borges, I. D. T., de Azevedo, P. O., Andreotti, J. P., de Paiva, A. E., de Almeida, V. M., Guerra, D. A. P., Santos, G. S. P., Mintz, A., et al. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.001 · Cited by 142 · see citing works
Coşkun, S., Chao, H., Vasavada, H. H., Heydari, K., Gonzales, N. M., Zhou, X., Crombrugghe, B. D., & Hirschi, K. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.013 · Cited by 133 · see citing works
Self-citationBiology of Infantile Hemangioma
Itinteang, T., Withers, A. H. J., Davis, P. F., & Tan, S. T. (2014) · Frontiers in Surgery · doi:10.3389/fsurg.2014.00038 · Cited by 125 · see citing works
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Cañete, A., Cano, E., Muñoz‐Chápuli, R., & Carmona, R. (2017) · Nutrients · doi:10.3390/nu9020159 · Cited by 117 · see citing works
Specification and function of hemogenic endothelium during embryogenesis
Gritz, E. C., & Hirschi, K. K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2134-0 · Cited by 114 · see citing works
Self-citationCirculating stem cells and cardiovascular outcomes: from basic science to the clinic
Fadini, G. P., Mehta, A., Dhindsa, D. S., Bonora, B. M., Sreejit, G., Nagareddy, P. R., & Quyyumi, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz923 · Cited by 94 · see citing works
Drosophila as a model for the two myeloid blood cell systems in vertebrates
Gold, K. S., & Brückner, K. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.06.002 · Cited by 94 · see citing works
Development of the lymphatic system: new questions and paradigms
Semo, J., Nicenboim, J., & Yaniv, K. (2016) · Development · doi:10.1242/dev.132431 · Cited by 90 · see citing works
Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86 · see citing works
Etv2 as an essential regulator of mesodermal lineage development
Koyano‐Nakagawa, N., & Garry, D. J. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx133 · Cited by 75 · see citing works
Exosomes in the Regulation of Vascular Endothelial Cell Regeneration
Baruah, J., & Wary, K. K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00353 · Cited by 71 · see citing works
Shi, X., Richard, J. J., Zirbes, K. M., Gong, W., Lin, G., Kyba, M., Thomson, J., Koyano‐Nakagawa, N., & Garry, D. J. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.02.018 · Cited by 66 · see citing works
Hematopoietic stem cells: An overview
Mosaad, Y. M. (2014) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2014.10.016 · Cited by 66 · see citing works
Kasaai, B., Caolo, V., Peacock, H. M., Lehoux, S., Perdiguero, E. G., Luttun, A., & Jones, E. A. V. (2017) · Scientific Reports · doi:10.1038/srep43817 · Cited by 58 · see citing works
Regulation of Hemogenic Endothelial Cell Development and Function
Wu, Y., & Hirschi, K. K. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034352 · Cited by 60 · see citing works
Self-citationAcute myeloid leukemia in the vascular niche
Cogle, C. R., Bosse, R. C., Brewer, T. M., Migdady, Y., Shirzad, R., Kampen, K. R., & Saki, N. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.05.007 · Cited by 56 · see citing works
Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis
Haznedaroğlu, İ. C., & Beyazıt, Y. (2012) · Clinical Science · doi:10.1042/cs20120300 · Cited by 54 · see citing works
Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation
Ratajczak, M. Z. (2017) · Leukemia · doi:10.1038/leu.2017.148 · Cited by 52 · see citing works
Cardiac Fibroblast Physiology and Pathology
Dostal, D. E., Glaser, S. S., & Baudino, T. A. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140053 · Cited by 52 · see citing works
Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches
Nakamura‐Ishizu, A., & Suda, T. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.023 · Cited by 49 · see citing works
Development and differentiation of the erythroid lineage in mammals
Barminko, J., Reinholt, B. M., & Baron, M. H. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.012 · Cited by 46 · see citing works
Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension
Jeong, E.-M., Pereira, M. G., So, E. Y., Wu, K. Q., Tatto, M. D., Wen, S., Dooner, M. S., Dubielecka, P. M., Reginato, A. M., Ventetuolo, C. E., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac001 · Cited by 45 · see citing works
Concise Review: Early Embryonic Erythropoiesis: Not so Primitive After All
Baron, M. H. (2013) · Stem Cells · doi:10.1002/stem.1342 · Cited by 43 · see citing works
Pelosi, E., Castelli, G., & Testa, U. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.11.004 · Cited by 40 · see citing works
Zamir, L., Singh, R., Nathan, E., Patrick, R., Yifa, O., Yahalom-Ronen, Y., Arraf, A. A., Schultheiss, T. M., Suo, S., Han, J. J., et al. (2017) · eLife · doi:10.7554/elife.20994 · Cited by 39 · see citing works
Development and pathologies of the arterial wall
Seidelmann, S. B., Lighthouse, J. K., & Greif, D. M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1478-y · Cited by 39 · see citing works
Shafiee, A., Patel, J., Hutmacher, D. W., Fisk, N. M., & Khosrotehrani, K. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.011 · Cited by 37 · see citing works
Kushwah, R., Guezguez, B., Lee, J. B., Hopkins, C. I., & Bhatia, M. (2014) · EMBO Reports · doi:10.15252/embr.201438842 · Cited by 35 · see citing works
Zhang, L., Jambusaria, A., Hong, Z., Marsboom, G., Tóth, P. T., Herbert, B., Malik, A. B., & Rehman, J. (2017) · Circulation · doi:10.1161/circulationaha.116.025722 · Cited by 37 · see citing works
Development of Hematopoietic Stem and Progenitor Cells From Human Pluripotent Stem Cells
Chen, T., Wang, F., Wu, M., & Wang, Z. Z. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25097 · Cited by 35 · see citing works
Bowers, S., Norden, P. R., & Davis, G. E. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.04.005 · Cited by 35 · see citing works
Alghisi, E., Distel, M., Malagola, M., Anelli, V., Santoriello, C., Herwig, L., Krudewig, A., Henkel, C. V., Russo, D., & Mione, M. (2013) · Leukemia · doi:10.1038/leu.2013.132 · Cited by 33 · see citing works
Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone
Paiva, A. E., Lousado, L., de Almeida, V. M., Andreotti, J. P., Santos, G. S. P., de Azevedo, P. O., Sena, I. F. G., Prazeres, P. H. D. M., Borges, I. T., Azevedo, V., et al. (2017) · Neoplasia · doi:10.1016/j.neo.2017.08.007 · Cited by 33 · see citing works
Human Kidney Organoids and Tubuloids as Models of Complex Kidney Disease
Nunez-Nescolarde, A. B., Nikolic‐Paterson, D. J., & Combes, A. N. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.01.009 · Cited by 32 · see citing works
Kim, J. Y., Lee, R. H., Kim, T. M., Kim, D., Jeon, Y.-J., Huh, S., Oh, S.-Y., Kyba, M., Kataoka, H., Choi, K., et al. (2014) · Blood · doi:10.1182/blood-2014-03-556332 · Cited by 31 · see citing works
Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors
Malinverno, M., Corada, M., Ferrarini, L., Formicola, L., Marazzi, G., Sassoon, D. A., & Dejana, E. (2017) · Stem Cells · doi:10.1002/stem.2566 · Cited by 29 · see citing works
The possible role of mutated endothelial cells in myeloproliferative neoplasms
Farina, M., Russo, D., & Hoffman, R. (2021) · Haematologica · doi:10.3324/haematol.2021.278499 · Cited by 28 · see citing works
Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension
Liang, O. D., So, E. Y., Egan, P., Goldberg, L. R., Aliotta, J. M., Wu, K. Q., Dubielecka, P. M., Ventetuolo, C. E., Reginato, A. M., Quesenberry, P. J., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx161 · Cited by 27 · see citing works
Developmental checkpoints guarded by regulated necrosis
Dillon, C. P., Tummers, B., Baran, K., & Green, D. R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2188-z · Cited by 26 · see citing works
MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells
Roy, L., Bikorimana, E., Lapid, D., Choi, H., Nguyen, T. A., & Dahl, R. E. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004959 · Cited by 25 · see citing works
Laiosa, M. D., & Tate, E. R. (2015) · Endocrinology · doi:10.1210/en.2015-1347 · Cited by 22 · see citing works
Lim, Z. R., Vassilev, S., Leong, Y. W., Hang, J. W., Rénia, L., Malleret, B., & Oh, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189808 · Cited by 24 · see citing works
Differential Etv2 threshold requirement for endothelial and erythropoietic development
Sinha, T., van Bueren, K. L., Dickel, D. E., Zlatanova, I., Thomas, R., Lizama, C. O., Xu, S.-M., Zovein, A. C., Ikegami, K., Moskowitz, I. P. G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110881 · Cited by 21 · see citing works
DNA methylation in hematopoietic development and disease
Gore, A. V., & Weinstein, B. M. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.04.013 · Cited by 23 · see citing works
Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart
Jankowska-Steifer, E. A., Madej, M., Niderla‐Bielińska, J., Rumiński, S., Flaht‐Zabost, A., Czarnowska, E., Gula, G., Radomska-Leśniewska, D. M., & Ratajska, A. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1269-z · Cited by 20 · see citing works
Enrichment of Scleroderma Vascular Disease–Associated Autoantigens in Endothelial Lineage Cells
McMahan, Z. H., Cottrell, T. R., Wigley, F. M., Antiochos, B., Zambidis, E. T., Park, T. S., Halushka, M. K., Gutierrez‐Alamillo, L., Cimbro, R., Rosen, A., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39743 · Cited by 20 · see citing works
Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract
Harikrishnan, K., Cooley, M. A., Sugi, Y., Barth, J. L., Rasmussen, L. M., Kern, C. B., Argraves, K. M., & Argraves, W. S. (2015) · Mechanisms of Development · doi:10.1016/j.mod.2014.12.005 · Cited by 20 · see citing works
Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program
Regano, D., Visintin, A., Clapero, F., Bussolino, F., Valdembri, D., Maione, F., Serini, G., & Giraudo, E. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.308226 · Cited by 17 · see citing works
Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture
Daniel, M. G., Sachs, D. M., Bernitz, J. M., Fstkchyan, Y. S., Rapp, K., Satija, N., Law, K., Patel, F., Gomes, A. M., Kim, H., et al. (2019) · FEBS Letters · doi:10.1002/1873-3468.13621 · Cited by 16 · see citing works
The hemangioblast: a state of competence
Amaya, E. (2013) · Blood · doi:10.1182/blood-2013-10-533075 · Cited by 14 · see citing works
Testa, U., Castelli, G., & Pelosi, E. (2020) · Stem Cell Investigation · doi:10.21037/sci.2020.03.02 · Cited by 12 · see citing works
Kilmister, E. J., & Tan, S. T. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.868187 · Cited by 13 · see citing works
The regulatory landscapes of human ovarian ageingPreprint
Chen, J., Wang, X., Hudgins, A. D., Gamliel, A., Pei, M., Kim, S.-S., Contreras, D., Hoeijmakers, J. H. J., Campisi, J., Løbo, R. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.18.492547 · Cited by 13 · see citing works
Robak, T. (2013) · Blood · doi:10.1182/blood-2013-10-534131 · Cited by 11 · see citing works
Cells with hematopoietic potential reside within mouse proepicardium
Jankowska-Steifer, E. A., Niderla‐Bielińska, J., Ciszek, B., Kujawa, M., Bartkowiak, M., Flaht‐Zabost, A., Kłosińska, D., & Ratajska, A. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1661-1 · Cited by 11 · see citing works
Incorporating placental tissue in cord blood banking for stem cell transplantation
Teofili, L., Silini, A. R., Bianchi, M., Valentini, C. G., & Parolini, O. (2018) · Expert Review of Hematology · doi:10.1080/17474086.2018.1483717 · Cited by 11 · see citing works
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Fang, J. S., Gritz, E. C., Marcelo, K. L., & Hirschi, K. K. (2016) · Journal of Visualized Experiments · doi:10.3791/54150 · Cited by 10 · see citing works
Self-citationStratman, A. N., Yu, J. A., Mulligan, T. S., Butler, M. G., Sause, E. T., & Weinstein, B. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00024-7 · Cited by 9 · see citing works
3D In Vitro Models of the Bone Marrow Niche
Scala, P., Serio, B., & Giudice, V. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01421 · Cited by 7 · see citing works
Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy
Shah, Z., Tian, L., Caligiuri, M. A., Kaufman, D. S., & Yu, J. (2026) · Cell stem cell · doi:10.1016/j.stem.2025.12.017 · Cited by 7 · see citing works
Vokes, S. A., & Krieg, P. A. (2015) · Springer eBooks · doi:10.1007/978-3-642-37078-6_2 · Cited by 7 · see citing works
A human bone marrow mesodermal-derived cell population with hemogenic potential
Mokhtari, S., Colletti, E. J., Yin, W., Sanada, C. D., Lamar, Z. S., Simmons, P. J., Walker, S., Bishop, C. E., Atala, A., Zanjani, E. D., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0016-1 · Cited by 7 · see citing works
Isolation of Murine Embryonic Hemogenic Endothelial Cells
Fang, J. S., Gritz, E. C., Marcelo, K. L., & Hirschi, K. K. (2016) · Journal of Visualized Experiments · doi:10.3791/54150-v · Cited by 6 · see citing works
Self-citationHemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos
Edwards, H. E., Elizalde, M., Souder, J. P., & Gorelick, D. A. (2023) · Development · doi:10.1242/dev.200500 · Cited by 5 · see citing works
Immune-mediated cardiac development and regeneration
Byatt, T. C., Razaghi, E., Tüzüner, S., & Simões, F. C. (2025) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2025.103613 · Cited by 6 · see citing works
Mallery, C. S., Carrillo, M., Mei, A. L., Correia‐Branco, A., Kashpur, O., & Wallingford, M. C. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00194-6 · Cited by 5 · see citing works
Cora, M. C., Latimer, K., & Travlos, G. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-391448-4.00025-3 · Cited by 5 · see citing works
Considerations on the Possible Origins of Fetal Hemoglobin Cells Produced in Developing Tumors
Wolk, M. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0450 · Cited by 5 · see citing works
Circulation Research Thematic Synopsis
Editors, T. (2012) · Circulation Research · doi:10.1161/circresaha.112.281006 · Cited by 3 · see citing works
Han, M. H., Kim, D., & Yu, K. (2023) · Organoid · doi:10.51335/organoid.2023.3.e2 · Cited by 3 · see citing works
Cardiac Fibroblast Physiology and Pathology
Dostal, D. E., Glaser, S. S., & Baudino, T. A. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00629.x · Cited by 3 · see citing works
Endothelial Cell Origin, Differentiation, Heterogeneity and Function
Grochot‐Przeczek, A., Kozakowska, M., Dulak, J., & Józkowicz, A. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1428-5_1 · Cited by 3 · see citing works
Signaling by Retinoic Acid in Embryonic and Adult Hematopoiesis
Cano, E., Ariza, L., Muñoz‐Chápuli, R., & Carmona, R. (2014) · Journal of Developmental Biology · doi:10.3390/jdb2010018 · Cited by 3 · see citing works
The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review
Taatjes, D. J., & Roth, J. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1417-8 · Cited by 3 · see citing works
Endothelial-to-hematopoietic transition is induced by Notch glycosylation and upregulation of MycnPreprint
Laruy, B. L., García-Gónzalez, I., Casquero-García, V., & Benedito, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.13.295238 · Cited by 3 · see citing works
Lithium Directs Embryonic Stem Cell Differentiation Into Hemangioblast‐Like Cells
Mnatsakanyan, H., Salmerón‐Sánchez, M., & Rico, P. (2020) · Advanced Biology · doi:10.1002/adbi.202000569 · Cited by 2 · see citing works
Delineation of Niches which Support Hematopoiesis
Lim, H. K., & O'Neill, H. C. (2014) · InTech eBooks · doi:10.5772/58715 · Cited by 2 · see citing works
Wilting, J., & Männer, J. (2015) · Springer eBooks · doi:10.1007/978-88-470-5673-2_1 · Cited by 2 · see citing works
Wading through the waves of human embryonic hemogenesis
Lis, R., Rafii, S., & James, D. (2013) · Cell Cycle · doi:10.4161/cc.24081 · Cited by 2 · see citing works
Lim, Y., Cheong, S. K., & Leong, P. P. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10855-2 · Cited by 1 · see citing works
Human cord blood-derived hemogenic endothelium generates mast cells
Castelli, G., D’Angiò, A., Grassi, G., Costa, V., Pasquini, L., Tiberio, R., Cerio, A. M., Testa, U., Tripodi, M., & Pelosi, E. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.11.002 · Cited by 1 · see citing works
Vascular Niche in HSC Development, Maintenance and Regulation
Coşkun, S., & Hirschi, K. K. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21705-5_9 · Cited by 1 · see citing works
Self-citationLyndina, Y., Sikora, V., Hyriavenko, N., Lyndіn, M., & Romaniuk, A. M. (2019) · Reports of Vinnytsia National Medical University · doi:10.31393/reports-vnmedical-2019-23(1)-09 · Cited by 1 · see citing works
Controlled Generation of Hematopoietic Progenitor Cells from Human Pluripotent Stem Cells
Rahman, M. N. (2017) · TSpace (University of Toronto) · Cited by 1 · see citing works
Hemo-Vasculogenesis in the Kidney and Heart
Hu, Y. (2016) · doi:10.18130/v3mw0v · Cited by 1 · see citing works
Feng, J., Yang, M., Li, C. C., Livák, F., Abdelmaksoud, A. A., Wang, D., & Tosato, G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.09.507292 · Cited by 1 · see citing works
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrowPreprint
Feng, J., Yang, M., Li, L., Li, C. C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553 · Cited by 1 · see citing works
Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrowPreprint
Feng, J., Yang, M., Li, L., Li, C. C., Livák, F., Chen, J., Zhao, Y., Wang, D., Bhandoola, A., Taylor, N. N., et al. (2026) · eLife · doi:10.7554/elife.109553.2 · Cited by 1 · see citing works
Identification of Arterial Phenotype in Endothelial Cells Derived From Human Pluripotent Stem Cells
Lepley, M. A. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
- Authors
- Hirschi, K. K.
- Affiliations
- Yale University (US)
- Corresponding author
- Hirschi, Karen K.
- ORCID
- Hirschi, Karen K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-05-24
- Volume
- 119
- Issue
- 21
- Pages
- 4823-4827
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3367889
- OpenAlex
- W2030242990
- Cited by
- 124
- References
- 52
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 15 · 2013: 12 · 2012: 3
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- hemogenic endothelium, hematopoietic stem cells, definitive hematopoiesis, yolk sac, placenta, aorta, fetal liver, fetal bone marrow, hematopoietic progenitor cells, embryonic development
- MeSH terms
- Adult, Animals, Hematopoiesis, Hematopoietic Stem Cells, Humans, Models, Biological, Embryonic Development, Growth and Development, Mice, Hemangioblasts
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