Cited by 124Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchAngiogenesis and VEGF in Cancer

Hemogenic endothelium during development and beyond

Open access
Hirschi, Karen K.·2012·Blood

Abstract

During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1182/blood-2011-12-353466

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Inducible lineage tracing of early hemogenic sites with Cdh5-cre does not account for all hematopoietic cells within the embryo.

    “Inducible lineage tracing of early hemogenic sites with Cdh5-cre, however, does not account for all hematopoietic cells within the embryo”

    From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Hirschi, 2012

    The “Hemogenic endothelial cells” section describes inducible VE-cadherin lineage tracing of cells labeled in the embryonic AGM. The “Postnatal hemogenic endothelium?” section says embryonically labeled HSCs do not account for all hematopoietic cells generated postnatally, not all hematopoietic cells within the embryo. The claim changes the population to which that finding applies. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. North TE, de Bruijn MF, Stacy T, et al. Runx1 ex- pression marks long-term repopulating hemato- poietic stem cells in the midgestation mouse em- bryo. Immunity. 2002;16(5):661-672.

Cited by

Sorted by citations

Authors
Hirschi, K. K.
Affiliations
Yale University (US)
Corresponding author
Hirschi, Karen K.
Venue
Blood
Published
2012-05-24
Volume
119
Issue
21
Pages
4823-4827
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2030242990
Cited by
124
References
52
Citations by year
2026: 6 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 15 · 2013: 12 · 2012: 3
FWCI
2.34
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
hemogenic endothelium, hematopoietic stem cells, definitive hematopoiesis, yolk sac, placenta, aorta, fetal liver, fetal bone marrow, hematopoietic progenitor cells, embryonic development
MeSH terms
Adult, Animals, Hematopoiesis, Hematopoietic Stem Cells, Humans, Models, Biological, Embryonic Development, Growth and Development, Mice, Hemangioblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review