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Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
Open accessAbstract
Data on the clinical spectrum and therapeutic management of noninfectious mixed cryoglobulinemia vasculitis (CryoVas) in the era of hepatitis C virus screening are lacking. We analyzed data from 242 patients with noninfectious mixed CryoVas included in the French multicenter CryoVas survey. Baseline manifestations were purpura (75%), peripheral neuropathy (52%), arthralgia or arthritis (44%), glomerulonephritis (35%), cutaneous ulcers (16%), and cutaneous necrosis (14%). A connective tissue disease was diagnosed in 30% and B-cell non-Hodgkin lymphoma in 22%, whereas the CryoVas was considered to be essential in 48%. With the use of Cox-marginal structural models, rituximab plus corticosteroids showed the greater therapeutic efficacy compared with corticosteroids alone and alkylating agents plus corticosteroids to achieve complete clinical, renal, and immunologic responses and a prednisone dosage < 10 mg/d at 6 months. However, this regimen was also associated with severe infections, particularly when high doses of corticosteroids were used, whereas death rates did not differ between the therapeutic regimens. The role of each of these strategies remains to be defined in well-designed randomized controlled trials.
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Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
Marginal Structural Models and Causal Inference in Epidemiology
Robins, J. M., Hernán, M. Á., & Brumback, B. (2000) · Epidemiology · doi:10.1097/00001648-200009000-00011 · Cited by 5,581
Cited by
Connelly‐Smith, L., Alquist, C. R., Aqui, N. A., Hofmann, J. C., Klingel, R., Onwuemene, O. A., Patriquin, C. J., Pham, H. P., Sanchez, A. P., Schneiderman, J., et al. (2023) · Journal of Clinical Apheresis · doi:10.1002/jca.22043 · Cited by 684
Hoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
Muchtar, E., Magen, H., & Gertz, M. A. (2017) · Blood · doi:10.1182/blood-2016-09-719773 · Cited by 190
Metadata
- Authors
- Terrier, B., Krastinova, E., Marie, I., Launay, D., Lacraz, A., Belenotti, P., de Saint-Martin, L., Quemeneur, T., Huart, A., Bonnet, F., Le Guenno, G., Kahn, J.-E., Hinschberger, O., Rullier, P., Diot, E., Lazaro, E., Bridoux, F., Zénone, T., Carrat, F., Hermine, O., Léger, J.-M., Mariette, X., Senet, P., Plaisier, E., & Cacoub, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-06-21
- Volume
- 119
- Issue
- 25
- Pages
- 5996-6004
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1985590116
- Cited by
- 241
- References
- 2
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Terrier, B., Krastinova, E., Marie, I., Launay, D., Lacraz, A., Belenotti, P., de Saint-Martin, L., Quemeneur, T., Huart, A., Bonnet, F., Le Guenno, G., Kahn, J.-E., Hinschberger, O., Rullier, P., Diot, E., Lazaro, E., Bridoux, F., Zénone, T., Carrat, F., . . . Cacoub, P. (2012). Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey. Blood. https://doi.org/10.1182/blood-2011-12-396028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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