The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
B Cells, Antibodies, and More
Open accessAbstract
B cells play a central role in the immunopathogenesis of glomerulonephritides and transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple mechanisms. In addition, B cells contribute to disease pathogenesis in autoimmunity and alloimmunity by presenting antigens as well as providing costimulation and cytokines to T cells. B cells also play an immunomodulatory role in regulating the immune response by secreting cytokines that inhibit disease onset and/or progression. B cell-targeted approaches for treating immune diseases of the kidney and other organs have gained significant momentum. However, much remains to be understood about B-cell biology in order to determine the timing, duration, and context of optimal therapeutic response to B cell-targeted approaches. In this review, we discuss the multifaceted roles of B cells as enhancers and regulators of immunity with relevance to kidney disease and transplantation.
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Metadata
- Authors
- Hoffman, W., Lakkis, F. G., & Chalasani, G.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2016-01
- Volume
- 11
- Issue
- 1
- Pages
- 137-154
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2219152942
- Cited by
- 482
- References
- 174
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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