Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach
Open accessAbstract
Key Points: In this study, African American MM patients have a significantly lower frequency of IgH translocations than European American patients.
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A study using genetic profiling and FISH testing to search for genetic foundations of greater MM risk among African Americans did not find significant results.
“A study that used genetic profiling and fluorescent in situ hybridization (FISH) testing to search for the genetic foundations of the greater risk among African Americans did not find significant results [15].”
From Epidemiology, Staging, and Management of Multiple Myeloma (2021) · cites this paper as [15]
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Epidemiology, Staging, and Management of Multiple Myeloma
Padala, S. A., Barsouk, A., Barsouk, A., Rawla, P., Vakiti, A., Kolhe, R., Kota, V., & Ajebo, G. H. (2021) · Medical Sciences · doi:10.3390/medsci9010003 · Cited by 332 · see citing works
“A study that used genetic profiling and fluorescent in situ hybridization (FISH) testing to search for the genetic foundations of the greater risk among African Americans did not find significant results [15].”
BackgroundCosta, L. J., Hari, P. N., & Kumar, S. K. (2016) · Leukemia & Lymphoma · doi:10.3109/10428194.2016.1170828 · Cited by 57 · see citing works
- Authors
- Baker, A., Braggio, E., Jacobus, S., Jung, S., Larson, D., Therneau, T., Dispenzieri, A., Van Wier, S. A., Ahmann, G., Levy, J., Perkins, L., Kim, S., Henderson, K., Vesole, D., Rajkumar, S. V., Jelinek, D. F., Carpten, J., & Fonseca, R.
- Affiliations
- Translational Genomics Research Institute (US)
- Mayo Clinic (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic Scottsdale, Scottsdale, AZ;
- Multiple Myeloma Research Foundation (US)
- Hackensack University Medical Center (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-04-18
- Volume
- 121
- Issue
- 16
- Pages
- 3147-3152
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3630830
- OpenAlex
- W2000150899
- Cited by
- 66
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 3
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA083724, P01CA062242, U10CA021115)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Keywords
- multiple myeloma, African Americans, racial disparities, IGH translocation, gene expression profiling, high-risk disease, cytogenetics, molecular alterations
- MeSH terms
- Black or African American, Humans, Immunoglobulin Heavy Chains, Multiple Myeloma, Translocation, Genetic, Cohort Studies, Gene Expression Profiling, Genomics, White People
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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