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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
Abstract
Key Points: LAMP1 silencing inhibits cytotoxicity of human NK cells. LAMP1 is important for perforin trafficking to the lytic granules and granule movement.
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LAMP-1 and LAMP-2 promote coupling of lysosomes to dynein-dynactin.
“LAMP-1 and LAMP-2 promote coupling of lysosomes to dynein–dynactin26,27”
From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [27]
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Cites
Functions of natural killer cells
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Perforin and granzymes: function, dysfunction and human pathology
Voskoboinik, I., Whisstock, J. C., & Trapani, J. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3839 · Cited by 1,327
The biogenesis of lysosomes and lysosome-related organelles
Luzio, J. P., Hackmann, Y., Dieckmann, N. M. G., & Griffiths, G. M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016840 · Cited by 330
Willett, R., Martina, J. A., Zewe, J. P., Wills, R., Hammond, G. R. V., & Puertollano, R. (2017) · Nature Communications · doi:10.1038/s41467-017-01871-z · Cited by 201
TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models
Roy, B., Contu, V. R., Jeziorek, M., Friedman, W. J., & Wong, C.-O. (2026) · doi:10.64898/2026.10.21.760809
Metadata
- Authors
- Krzewski, K., Gil-Krzewska, A., Nguyen, V., Peruzzi, G., & Coligan, J. E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-06-06
- Volume
- 121
- Issue
- 23
- Pages
- 4672-4683
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 170
- References
- 2
- Language
- en
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