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CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

Gekas, Christos, Graf, Thomas·2013·Blood
DOI 10.1182/blood-2012-09-457929
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Abstract

Key Points: Integrin CD41, thought to absent on adult HSCs, marks a novel subset of myeloid-biased long-term HSCs that becomes prevalent with age. Loss of CD41 leads to transplantable hematopoietic defects that affect HSC survival and maintenance and are, in part, mediated by platelet loss.

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Metadata

Authors
Gekas, C., & Graf, T.
Venue
Blood
Publisher
American Society of Hematology
Published
2013-05-30
Volume
121
Issue
22
Pages
4463-4472
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2012-09-457929
Cited by
352
References
5
Language
en

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