Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages
Abstract
We performed an immunohistological study using biopsy samples of bone marrow obtained from patients, ranging in age from a newborn baby to 100 years old. Those patients suffering from hematological diseases or diseases that would be capable of affecting hematopoiesis were not included in the present study. The cellularity of the bone marrow did not change significantly with age during the first and the eighth decades, while the oldest group, ranging in age from 80 to 100, revealed significantly low cellularity. Proliferative activity assessed by Ki-67-positive cells was high in the middle-aged group and declined slightly in the elderly group. It was of interest to note that the percentage of apoptosis was relatively low in the young and middle-aged group, but significantly increased in the elderly group. The percentage of T cells did not change greatly between the first and the fifth decades, peaked at the sixth decade and gradually decreased thereafter. The percentage of B cells was about 10% at the first decade, decreased thereafter until the third decade, then increased again showing a peak at the sixth decade, and decreased thereafter. The percentage of CD68-positive cells was high in young patients, and decreased in the adult and elderly patients. The data in the present study suggest that hypocellularity in the bone marrow of elderly people could be ascribed partly to the increase of apoptosis, and might possibly be related to a decrease in the number of lymphocytes and macrophages, which would constitute part of the bone marrow microenvironment supporting hematopoiesis.
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Bone marrow from children and young adults under 19 years contains significantly more macrophages than adult bone marrow.
“Interestingly, bone marrow in children and young adults (<19 years of age) contains significantly more macrophages as compared to adults (58).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [58]
In human bone marrow, the number of CD68+ macrophages does not change significantly across adult life.
“This contradicts a study performed on human bone marrow, where no significant difference in the number of CD68 + macrophages throughout adult life is observed.”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [58]
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- Authors
- Ogawa, T., Kitagawa, M., & Hirokawa, K.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Kitagawa, Masanobu
- ORCID
- Kitagawa, Masanobu
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 117
- Issue
- 1-3
- Pages
- 57-68
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W1969606315
- Cited by
- 224
- References
- 27
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 10 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 12
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bone marrow aging, bone marrow cellularity, hypocellular bone marrow, apoptosis, Ki-67, proliferative activity, T cells, B cells, macrophages, CD68, hematopoiesis, bone marrow microenvironment, lymphocytes
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Bone Marrow, Bone Marrow Cells, Cell Division, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Macrophages, Male, Middle Aged, T-Lymphocytes, Apoptosis, Ki-67 Antigen
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