The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
EBV-positive diffuse large B-cell lymphoma of the elderly
Open accessAbstract
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly, initially described in 2003, is a provisional entity in the 2008 World Health Organization classification system and is defined as an EBV-positive monoclonal large B-cell proliferation that occurs in patients >50 years of age and in whom there is no known immunodeficiency or history of lymphoma. These tumors are more common in Asia but also occur in North America and Europe at a low frequency. These neoplasms exhibit a morphologic continuum, from polymorphous to monomorphous, but morphologic features do not correlate with prognosis as all patients have a clinically aggressive course. Most EBV-positive DLBCL of the elderly patients have an activated B-cell immunophenotype and are characterized by prominent nuclear factor-κB activation. Cytogenetic complexity is usually low. In this review, we comprehensively delineate the data emerging from analyses of EBV latency program, microRNA-mediated EBV viral oncogenesis, functional genomics of EBV and its biology, and differential diagnosis challenge for EBV-positive DLBCL of the elderly. It is hoped that the improved understanding of these tumors will lead to the development of novel therapeutic approaches, enhance the effectiveness of clinical trials, and improve prognosis.
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BackgroundIdentification of Virus-Encoded MicroRNAs
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Cited by
Kimura, H., Ito, Y., Kawabe, S., Gotoh, K., Takahashi, Y., Kojima, S., Naoe, T., Esaki, S., Kikuta, A., Sawada, A., et al. (2012) · Blood · doi:10.1182/blood-2011-10-381921 · Cited by 448
Metadata
- Authors
- Ok, C. Y., Papathomas, T. G., Medeiros, L. J., & Young, K. H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-07-18
- Volume
- 122
- Issue
- 3
- Pages
- 328-340
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2014485235
- Cited by
- 260
- References
- 69
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Ok, C. Y., Papathomas, T. G., Medeiros, L. J., & Young, K. H. (2013). EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. https://doi.org/10.1182/blood-2013-03-489708
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
