The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival
Open accessAbstract
Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to express microRNAs (miRNAs), the functions of which remain largely unknown. We report on the regulation of a cellular protein named p53 up-regulated modulator of apoptosis (PUMA) by an EBV miRNA known as miR-BART5, which is abundantly expressed in NPC and EBV-GC cells. Modulation of PUMA expression by miR-BART5 and anti–miR-BART5 oligonucleotide was demonstrated in EBV-positive cells. In addition, PUMA was found to be significantly underexpressed in ∼60% of human NPC tissues. Although expression of miR-BART5 rendered NPC and EBV-GC cells less sensitive to proapoptotic agents, apoptosis can be triggered by depleting miR-BART5 or inducing the expression of PUMA. Collectively, our findings suggest that EBV encodes an miRNA to facilitate the establishment of latent infection by promoting host cell survival.
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PUMA, a potent killer with or without p53
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Metadata
- Authors
- Choy, E. Y.-W., Siu, K.-L., Kok, K.-H., Lung, R. W.-M., Tsang, C. M., To, K.-F., Kwong, D. L.-W., Tsao, S. W., & Jin, D.-Y.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-10-06
- Volume
- 205
- Issue
- 11
- Pages
- 2551-2560
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2115503551
- Cited by
- 462
- References
- 42
- FWCI
- 15.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Choy, E. Y.-W., Siu, K.-L., Kok, K.-H., Lung, R. W.-M., Tsang, C. M., To, K.-F., Kwong, D. L.-W., Tsao, S. W., & Jin, D.-Y. (2008). An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20072581
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