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Cited by 420Blood properties and coagulationBlood Coagulation and Thrombosis MechanismsTrauma, Hemostasis, Coagulopathy, Resuscitation

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Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

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Cines, Douglas B., Lebedeva, Tatiana, Nagaswami, Chandrasekaran, Hayes, Vincent, Massefski, Walter, Litvinov, Rustem I., Rauova, Lubica, Lowery, Thomas J., Weisel, John W.·2014·Blood
DOI 10.1182/blood-2013-08-523860PMC PMC3945867
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Abstract

Key Points: In contracted clots and thrombi, erythrocytes are compressed to close-packed polyhedral structures with platelets and fibrin on the surface. Polyhedrocytes form an impermeable seal to stem bleeding and help prevent vascular obstruction but confer resistance to fibrinolysis.

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Metadata

Authors
Cines, D. B., Lebedeva, T., Nagaswami, C., Hayes, V., Massefski, W., Litvinov, R. I., Rauova, L., Lowery, T. J., & Weisel, J. W.
Affiliations
  • Department of Pathology and Laboratory Medicine and
  • University of Pennsylvania (US)
  • Children's Hospital of Philadelphia (US)
  • T2 Biosystems, Lexington, MA; and
  • Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2014-03-06
Volume
123
Issue
10
Pages
1596-1603
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2013-08-523860
PMC
PMC3945867
OpenAlex
W2029983754
Cited by
420
References
0
Citations by year
2026: 35 · 2025: 47 · 2024: 26 · 2023: 44 · 2022: 36 · 2021: 55 · 2020: 36 · 2019: 28 · 2018: 41 · 2017: 26 · 2016: 22 · 2015: 14 · 2014: 10
FWCI
11.37
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL090774, P01HL110860, HL110860, R56HL090774, HL090774)
Topics
  • Health Sciences › Medicine › Hematology › Blood properties and coagulation
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
clot retraction, platelet aggregates, clot structure, hemostasis, wound healing, arterial thrombi, fibrinolysis, platelet cytoskeleton
MeSH terms
Animals, Blood Coagulation, Blood Platelets, Coronary Vessels, Deuterium, Erythrocytes, Fibrin, Humans, Hydrogen, Platelet Aggregation, Thrombosis, Mice

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