Cited by 93Cutaneous lymphoproliferative disorders researchLymphoma Diagnosis and TreatmentMultiple Myeloma Research and Treatments

Results of an open-label multicenter phase 2 trial of lenalidomide monotherapy in refractory mycosis fungoides and Sézary syndrome

Querfeld, Christiane, Rosen, Steven T., Guitart, Joan, Duvic, Madeleine, Kim, Youn H., Dusza, Stephen W., Kuzel, Timothy M.·2014·Blood

Abstract

Key Points: Lenalidomide is effective in refractory advanced cutaneous T-cell lymphoma, with an overall response rate of 28%. Patients demonstrate a transient flare reaction in skin, blood, and/or lymph nodes that may be associated with improvement in disease burden.

Integrity signals

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Crossref · 10.1182/blood-2013-09-525915

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Del(5q) is the most common cytogenetic abnormality in MDS; patients with this genetic aberration often present with a consistent clinical phenotype, termed the 5q− syndrome, which is more common in women than in men and has a relatively indolent course characterized by hypoplastic anaemia.

    “Del(5q) is the most common cytogenetic abnormality in MDS; patients with this genetic aberration often present with a consistent clinical phenotype, termed the ‘5q− syndrome’, which is more common in women than in men and has a relatively indolent course characterized by hypoplastic anaemia95.”

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Authors
Querfeld, C., Rosen, S. T., Guitart, J., Duvic, M., Kim, Y. H., Dusza, S. W., & Kuzel, T. M.
Affiliations
  • Memorial Sloan Kettering Cancer Center (US)
  • Northwestern University (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • Stanford University (US)
  • Department of Medicine, Division of Hematology/Oncology and
Venue
Blood
Published
2014-02-20
Volume
123
Issue
8
Pages
1159-1166
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1990288154
Cited by
93
References
38
Citations by year
2026: 2 · 2025: 9 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 5 · 2012: 1
FWCI
7.43
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Funders
Celgene
Topics
  • Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
Keywords
lenalidomide, mycosis fungoides, Sézary syndrome, cutaneous T-cell lymphoma, refractory disease, monotherapy, fatigue, CD25+ T cells, CD4/CD8 ratio, Foxp3, CD8+ T cells, adverse events
MeSH terms
Lenalidomide, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Immunologic Factors, Male, Middle Aged, Mycosis Fungoides, Sezary Syndrome, Thalidomide, Treatment Outcome, Disease-Free Survival, Angiogenesis Inhibitors

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