Results of an open-label multicenter phase 2 trial of lenalidomide monotherapy in refractory mycosis fungoides and Sézary syndrome
Abstract
Key Points: Lenalidomide is effective in refractory advanced cutaneous T-cell lymphoma, with an overall response rate of 28%. Patients demonstrate a transient flare reaction in skin, blood, and/or lymph nodes that may be associated with improvement in disease burden.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Del(5q) is the most common cytogenetic abnormality in MDS; patients with this genetic aberration often present with a consistent clinical phenotype, termed the 5q− syndrome, which is more common in women than in men and has a relatively indolent course characterized by hypoplastic anaemia.
“Del(5q) is the most common cytogenetic abnormality in MDS; patients with this genetic aberration often present with a consistent clinical phenotype, termed the ‘5q− syndrome’, which is more common in women than in men and has a relatively indolent course characterized by hypoplastic anaemia95.”
From Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide (2021) · cites this paper as [95]
Cites
WHO-EORTC classification for cutaneous lymphomas
Willemze, R. (2005) · Blood · doi:10.1182/blood-2004-09-3502 · Cited by 3,803 · see citing works
Optimal two-stage designs for phase II clinical trials.
Simon, R. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90015-9 · Cited by 3,636 · see citing works
Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., Chiao, J. H., Reilly, J. F., Ricker, J. L., Richon, V. M., et al. (2007) · Blood · doi:10.1182/blood-2006-06-025999 · Cited by 1,141 · see citing works
Self-citationEfficacy of Lenalidomide in Myelodysplastic Syndromes
List, A., Kurtin, S., Roe, D. J., Buresh, A., Mahadevan, D., Fuchs, D., Rimsza, L., Heaton, R., Knight, R., & Zeldis, J. B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041668 · Cited by 880 · see citing works
Agar, N., Wedgeworth, E. K., Crichton, S. L., Mitchell, T. J., Cox, M., Ferreira, S., Robson, A., Calonje, E. J., Stefanato, C. M., Wain, E. M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.7665 · Cited by 852 · see citing works
The evolution of thalidomide and its IMiD derivatives as anticancer agents
Bartlett, J. B., Dredge, K. S., & Dalgleish, A. G. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1323 · Cited by 811 · see citing works
Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma
Palumbo, A. P., Hájek, R., Delforge, M., Kropff, M. H., Petrucci, M. T., Catalano, J. V., Gisslinger, H., Wiktor-Jędrzejczak, W., Zodelava, M., Weisel, K. C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112704 · Cited by 739 · see citing works
Piekarz, R., Frye, R., Turner, M. L. C., Wright, J. J., Allen, S. L., Kirschbaum, M. H., Zain, J. M., Prince, H. M., Leonard, J. P., Geskin, L. J., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.6150 · Cited by 739 · see citing works
Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases
Bradford, P. T., Devesa, S. S., Anderson, W. F., & Toro, J. R. (2009) · Blood · doi:10.1182/blood-2008-10-184168 · Cited by 707 · see citing works
Duvic, M., Hymes, K., Heald, P., Breneman, D., Martin, A. G., Myskowski, P., Crowley, C., Yocum, R. C., & for Members of the Bexarotene Worldwide Study Group (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.9.2456 · Cited by 706 · see citing works
Self-citationOlsen, E. A., Whittaker, S. J., Kim, Y. H., Duvic, M. A., Prince, H. M., Lessin, S. R., Wood, G. S., Willemze, R., Demierre, M., Pimpinelli, N., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.0630 · Cited by 668 · see citing works
Self-citationWhittaker, S. J., Demierre, M., Kim, E. J., Rook, A. H., Lerner, A., Duvic, M. A., Scarisbrick, J. J., Reddy, S. A., Robak, T., Becker, J. C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.9066 · Cited by 666 · see citing works
Self-citationIncidence of Cutaneous T-Cell Lymphoma in the United States, 1973-2002
Criscione, V. D., & Weinstock, M. A. (2007) · Archives of Dermatology · doi:10.1001/archderm.143.7.854 · Cited by 528 · see citing works
Fenaux, P., Giagounidis, A. A. N., Selleslag, D., Beyne‐Rauzy, O., Mufti, G. J., Mittelman, M., Muus, P., Boekhorst, P. A. W. T., Sanz, G. F., del Cañizo, C., et al. (2011) · Blood · doi:10.1182/blood-2011-01-330126 · Cited by 488 · see citing works
Kaye, F. J., Bunn, P. A., Steinberg, S. M., Stocker, J., Ihde, D. C., Fischmann, A. B., GLATSTEIN, E. J., Schechter, G. P., Phelps, R. M., Foss, F. M., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212603 · Cited by 487 · see citing works
Mechanism of action of lenalidomide in hematological malignancies
Kotla, V., Goel, S., Nischal, S., Heuck, C. J., Vivek, K., Das, B. C., & Verma, A. K. (2009) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-2-36 · Cited by 466 · see citing works
Duvic, M. A., Martín, Á. G., Kim, Y. H., Olsen, E. A., Wood, G. S., Crowley, C., & Yocum, R. C. (2001) · PubMed · Cited by 435 · see citing works
Self-citationChanan-Khan, A. A., Miller, K. C., Musial, L., Lawrence, D. D., Padmanabhan, S., Takeshita, K., Porter, C. W., Goodrich, D. W., Bernstein, Z. P., Wallace, P. K., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.0401 · Cited by 414 · see citing works
Lundin, J., Hagberg, H., Repp, R., Cavallin-Ståhl, E. K., Fredén, S., Juliusson, G., Rosenblad, E., Tjønnfjord, G. E., Wiklund, T. A., & Österborg, A. (2003) · Blood · doi:10.1182/blood-2002-09-2802 · Cited by 390 · see citing works
Lenalidomide Monotherapy in Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma
Wiernik, P. H., Lossos, I. S., Tuscano, J. M., Justice, G. R., Vose, J. M., Cole, C. E., Lam, W., McBride, K., Wride, K., PIETRONIGRO, D. D., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.3429 · Cited by 371 · see citing works
Witzig, T. E., Wiernik, P. H., Moore, T. D., Reeder, C. B., Cole, C. E., Justice, G. R., Kaplan, H. G., Voralia, M., PIETRONIGRO, D. D., Takeshita, K., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.1169 · Cited by 259 · see citing works
Habermann, T. M., Lossos, I. S., Justice, G. R., Vose, J. M., Wiernik, P. H., McBride, K., Wride, K., Ervin-Haynes, A. L., Takeshita, K., PIETRONIGRO, D. D., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07626.x · Cited by 244 · see citing works
Prince, H. M., Duvic, M. A., Martin, A., Sterry, W., Assaf, C., Sun, Y., Straus, D. J., Acosta, M., & Negro-Vilar, A. F. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.2386 · Cited by 233 · see citing works
Self-citationKim, Y. H., Duvic, M. A., Obitz, E., Gniadecki, R., Iversen, L., Österborg, A., Whittaker, S. J., Illidge, T., Schwarz, T., Kaufmann, R., et al. (2007) · Blood · doi:10.1182/blood-2006-12-062877 · Cited by 204 · see citing works
Self-citationFOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival
Gjerdrum, L. M. R., Woetmann, A., Ødum, N., Burton, C. M., Rossen, K., Skovgaard, G. L., Ryder, L. P., & Ralfkiaer, E. M. (2007) · Leukemia · doi:10.1038/sj.leu.2404913 · Cited by 158 · see citing works
Horwitz, S. M., Kim, Y. H., Foss, F., et al. (2012) · Blood · doi:10.1182/blood-2011-11-390211 · Cited by 132 · see citing works
Self-citationMorschhauser, F., Fitoussi, O., Haioun, C., Thieblemont, C., Quach, H., Delarue, R., Glaisner, S., Gabarre, J., Bosly, A., Lister, J., et al. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.04.029 · Cited by 131 · see citing works
Duvic, M., Dummer, R., Becker, J. C., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.08.017 · Cited by 127 · see citing works
Self-citationGuitart, J., Kennedy, J., Ronan, S., Chmiel, J. S., Hsiegh, Y., & Variakojis, D. (2001) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2001.028004174.x · Cited by 120 · see citing works
Self-citationLack of Suppressive CD4+CD25+FOXP3+ T Cells in Advanced Stages of Primary Cutaneous T-Cell Lymphoma
Tiemessen, M. M., Mitchell, T. J., Hendry, L., Whittaker, S. J., Taams, L. S., & John, S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700371 · Cited by 99 · see citing works
Chong, B. F., Wilson, A. J., Gibson, H. M., Hafner, M. S., Luo, Y. H., Hedgcock, C. J., & Wong, H. K. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0610 · Cited by 99 · see citing works
Chanan-Khan, A. A., Miller, K. C., Lawrence, D. D., Padmanabhan, S., Miller, A., Hernandez‐Illatazurri, F., Czuczman, M. S., Wallace, P. K., Zeldis, J. B., & Lee, K. P. (2010) · Cancer · doi:10.1002/cncr.25748 · Cited by 90 · see citing works
Chanan-Khan, A. A., Chitta, K. S., Ersing, N., Paulus, A., Masood, A., Sher, T., Swaika, A., Wallace, P. K., Mashtare, T. L., Wilding, G. E., et al. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08882.x · Cited by 69 · see citing works
Yang, B. Y., Yu, R., Chi, X.-H., & Lu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064354 · Cited by 52 · see citing works
Vose, J. M., Habermann, T. M., Czuczman, M. S., Zinzani, P. L., Reeder, C. B., Tuscano, J. M., Lossos, I. S., Li, J., PIETRONIGRO, D. D., & Witzig, T. E. (2013) · British Journal of Haematology · doi:10.1111/bjh.12449 · Cited by 38 · see citing works
Segler, A., & Tsimberidou, A. M. (2012) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-012-1874-2 · Cited by 36 · see citing works
Lenalidomide in Diffuse Large B-Cell Lymphoma
Thiéblemont, C., Delfau‐Larue, M., & Coiffier, B. (2012) · Advances in Hematology · doi:10.1155/2012/861060 · Cited by 21 · see citing works
Prognostic markers in mycosis fungoides.
Goteri, G., Rupoli, S., Pulini, S., et al. (2008) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
Jan, M., Sperling, A. S., & Ebert, B. L. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00479-z · Cited by 137 · see citing works
- Authors
- Querfeld, C., Rosen, S. T., Guitart, J., Duvic, M., Kim, Y. H., Dusza, S. W., & Kuzel, T. M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Northwestern University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Stanford University (US)
- Department of Medicine, Division of Hematology/Oncology and
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-02-20
- Volume
- 123
- Issue
- 8
- Pages
- 1159-1166
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1990288154
- Cited by
- 93
- References
- 38
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 5 · 2012: 1
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Celgene
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Keywords
- lenalidomide, mycosis fungoides, Sézary syndrome, cutaneous T-cell lymphoma, refractory disease, monotherapy, fatigue, CD25+ T cells, CD4/CD8 ratio, Foxp3, CD8+ T cells, adverse events
- MeSH terms
- Lenalidomide, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Immunologic Factors, Male, Middle Aged, Mycosis Fungoides, Sezary Syndrome, Thalidomide, Treatment Outcome, Disease-Free Survival, Angiogenesis Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review