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A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
Abstract
Key Points: AITL is characterized by high frequencies of overlapping mutations in epigenetic modifiers, including TET2, IDH2, and DNMT3A. Targetable mutations are present in a subset of cases.
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“Over a two-year follow-up period, patients with SMM with low-risk features have a progression rate of less than 10%, whereas those with high-risk features have a progression rate greater than 60%.”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [221]
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“The rate of progression from smouldering multiple myeloma (SMM) to multiple myeloma (MM) varies significantly depending on specific SMM disease characteristics, including M protein quantity, percentage of monoclonal plasma cells in the bone marrow and disease cytogenetics 221 .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [221]
In the citing paper
“Genetically, AITL is characterized by a number of genomic mutations in TET2, RHOA, DNMT3A, and IDH2”
From Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking (2021) · cites this paper as Odejide et al., 2014
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Cites
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Morin, R. D., Mendez-Lago, M., Mungall, A. J., Goya, R., Mungall, K. L., Corbett, R. D., Johnson, N. A., Severson, T. M., Chiu, R., Field, M., et al. (2011) · Nature · doi:10.1038/nature10351 · Cited by 1,614
MDM2, MDMX and p53 in oncogenesis and cancer therapy
Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279
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Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice
Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.008 · Cited by 295
Self-citationClonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones
Challen, G., & Goodell, M. A. (2020) · Blood · doi:10.1182/blood.2020006510 · Cited by 131
Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells
Shenoy, N., Bhagat, T., Nieves, E., Stenson, M., Lawson, J., Choudhary, G. S., Habermann, T., Nowakowski, G., Singh, R., Wu, X., et al. (2017) · Blood Cancer Journal · doi:10.1038/bcj.2017.65 · Cited by 111
Metadata
- Authors
- Odejide, O., Weigert, O., Lane, A. A., Toscano, D., Lunning, M. A., Kopp, N., Kim, S., van Bodegom, D., Bolla, S., Schatz, J. H., Teruya-Feldstein, J., Hochberg, E., Louissaint, A., Dorfman, D., Stevenson, K., Rodig, S. J., Piccaluga, P. P., Jacobsen, E., Pileri, S. A., Harris, N. L., Ferrero, S., Inghirami, G., Horwitz, S. M., & Weinstock, D. M.
- Affiliations
- Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;
- Department of Medicine and
- Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY;
- Department of Pathology, Massachusetts General Hospital, Boston, MA;
- Department of Pathology, Brigham and Women’s Hospital, Boston, MA;
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;
- Unit of Hematopathology, Orsola Malpighi Hospital, Bologna, Italy; and
- Divisione di Ematologia, Universita di Torino, Torino, Italy
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-02-27
- Volume
- 123
- Issue
- 9
- Pages
- 1293-1296
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 398
- References
- 2
- Language
- en
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- Odejide, O., Weigert, O., Lane, A. A., Toscano, D., Lunning, M. A., Kopp, N., Kim, S., van Bodegom, D., Bolla, S., Schatz, J. H., Teruya-Feldstein, J., Hochberg, E., Louissaint, A., Dorfman, D., Stevenson, K., Rodig, S. J., Piccaluga, P. P., Jacobsen, E., Pileri, S. A., . . . Weinstock, D. M. (2014). A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood. https://doi.org/10.1182/blood-2013-10-531509