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Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study
Open accessAbstract
Key Points: Pomalidomide plus low-dose dexamethasone significantly improved PFS vs pomalidomide alone in relapsed and refractory multiple myeloma. Pomalidomide plus low-dose dexamethasone is an important new treatment option for RRMM patients who have received multiple prior therapies.
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“Data from a number of in vitro studies support the hypothesis that thalidomide analogues synergize with dexamethasone49,50, proteasome inhibitors51,52, histone deacetylase inhibitors53,54 and a variety of other agents”
From Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide (2021) · cites this paper as [50]
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Metadata
- Authors
- Richardson, P. G., Siegel, D. S., Vij, R., Hofmeister, C. C., Baz, R., Jagannath, S., Chen, C., Lonial, S., Jakubowiak, A., Bahlis, N., Song, K., Belch, A., Raje, N., Shustik, C., Lentzsch, S., Lacy, M., Mikhael, J., Matous, J., Vesole, D., Chen, M., Zaki, M. H., Jacques, C., Yu, Z., & Anderson, K. C.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Hackensack University Medical Center (US)
- Washington University in St. Louis (US)
- The Ohio State University (US)
- Moffitt Cancer Center (US)
- Mount Sinai Medical Center, New York, NY;
- Princess Margaret Cancer Centre (CA)
- Emory University (US)
- University of Chicago Medical Center (US)
- University of Calgary (CA)
- Vancouver General Hospital (CA)
- University of Alberta (CA)
- Massachusetts General Hospital (US)
- Royal Victoria Hospital (CA)
- Columbia University (US)
- Mayo Clinic (US)
- Colorado Blood Cancer Institute (US)
- Celgene (United States) (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-03-20
- Volume
- 123
- Issue
- 12
- Pages
- 1826-1832
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3962162
- OpenAlex
- W2091773528
- Cited by
- 381
- References
- 43
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 39 · 2021: 30 · 2020: 31 · 2019: 24 · 2018: 30 · 2017: 54 · 2016: 48 · 2015: 48 · 2014: 27
- FWCI
- 41.83
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-05-15)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Celgene
- National Cancer Institute (P50CA100707, P01CA155258, P30CA016058)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- pomalidomide, low-dose dexamethasone, relapsed/refractory multiple myeloma, progression-free survival, lenalidomide-refractory disease, bortezomib resistance, combination therapy, neutropenia, peripheral neuropathy, overall survival, overall response rate
- MeSH terms
- Bortezomib, Lenalidomide, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Dexamethasone, Female, Humans, Immunologic Factors, Male, Middle Aged, Multiple Myeloma, Neoplasm Recurrence, Local, Neutropenia, Pyrazines, Thalidomide, Treatment Outcome, Disease-Free Survival, Drug Resistance, Neoplasm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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