The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
von Willebrand factor, Jedi knight of the bloodstream
Open accessAbstract
When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use “the Force” to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compact VWF during biosynthesis. A2 domain unfolding by hydrodynamic force enables postsecretion regulation of VWF length. Mutations in VWF in von Willebrand disease contribute to and are illuminated by VWF biology. I attempt to integrate classic studies on the physiology of hemostatic plug formation into modern molecular understanding, and point out what remains to be learned.
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Cites
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Cited by
Hansson, G. C. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105053 · Cited by 409
Forms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138
Jesudas, R., Chaudhury, A., & Laukaitis, C. M. (2019) · Haemophilia · doi:10.1111/hae.13800 · Cited by 43
Cryo-EM structure of native honey bee vitellogenin
Montserrat-Canals, M., Schnelle, K., Leipart, V., Halskau, Ø., Amdam, G. V., Moeller, A., Cunha, E. S., & Luecke, H. (2025) · Nature Communications · doi:10.1038/s41467-025-58575-y · Cited by 7
Metadata
- Authors
- Springer, T. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-08-28
- Volume
- 124
- Issue
- 9
- Pages
- 1412-1425
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1985726492
- Cited by
- 444
- References
- 67
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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