The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis
Open accessAbstract
Key Points: Recurrent somatic mutations in MAP2K1 were identified in 33% of LCH lesions with wild-type BRAF. The mutant MAPK kinase 1 proteins activate ERK. The ability of MAPK pathway inhibitors to suppress MAPK kinase and ERK phosphorylation in vitro was dependent on the specific LCH mutation.
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Citations
Cites
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
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A landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, K. M., & Rosen, N. (2010) · Nature · doi:10.1038/nature08902 · Cited by 1,811
Self-citationMapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789
Recurrent BRAF mutations in Langerhans cell histiocytosis
Badalian-Very, G., Vergilio, J.-A., Degar, B. A., MacConaill, L. E., Brandner, B., Calicchio, M. L., Kuo, F. C., Ligon, A. H., Stevenson, K. E., Kehoe, S. M., et al. (2010) · Blood · doi:10.1182/blood-2010-04-279083 · Cited by 1,243
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
the International Cancer Genome Consortium PedBrain Tumor Project, Jones, D. T. W., Hutter, B., Jäger, N., Korshunov, A., Kool, M., Warnatz, H.-J., Zichner, T., Lambert, S. R., Ryzhova, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2682 · Cited by 825
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Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
Lundberg, P., Karow, A., Nienhold, R., Looser, R., Hao-Shen, H., Nissen, I., Girsberger, S., Lehmann, T., Passweg, J., Stern, M., et al. (2014) · Blood · doi:10.1182/blood-2013-11-537167 · Cited by 634
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Rodriguez-Galindo, C., & Allen, C. E. (2020) · Blood · doi:10.1182/blood.2019000934 · Cited by 361
Self-citationMutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai–Dorfman disease
Garces, S., Medeiros, L. J., Patel, K. P., Li, S., Pina-Oviedo, S., Li, J., Garces, J. C., Khoury, J. D., & Yin, C. C. (2017) · Modern Pathology · doi:10.1038/modpathol.2017.55 · Cited by 299
Goyal, G., Tazi, A., Go, R. S., Rech, K. L., Picarsic, J. L., Vassallo, R., Young, J. R., Cox, C. W., Van Laar, J., Hermiston, M. L., et al. (2022) · Blood · doi:10.1182/blood.2021014343 · Cited by 283
Self-citationLangerhans cell origin and regulation
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Metadata
- Authors
- Chakraborty, R., Hampton, O. A., Shen, X., Simko, S. J., Shih, A., Abhyankar, H., Lim, K. P. H., Covington, K. R., Trevino, L., Dewal, N., Muzny, D. M., Doddapaneni, H., Hu, J., Wang, L., Lupo, P. J., Hicks, M. J., Bonilla, D. L., Dwyer, K. C., Berres, M.-L., Poulikakos, P. I., Merad, M., McClain, K. L., Wheeler, D. A., Allen, C. E., & Parsons, D. W.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-11-06
- Volume
- 124
- Issue
- 19
- Pages
- 3007-3015
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2055389755
- Cited by
- 431
- References
- 39
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. https://app.cochat.ai/papers/10.1182/blood-2014-05-577825
- The paper
- Chakraborty, R., Hampton, O. A., Shen, X., Simko, S. J., Shih, A., Abhyankar, H., Lim, K. P. H., Covington, K. R., Trevino, L., Dewal, N., Muzny, D. M., Doddapaneni, H., Hu, J., Wang, L., Lupo, P. J., Hicks, M. J., Bonilla, D. L., Dwyer, K. C., Berres, M.-L., . . . Parsons, D. W. (2014). Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood. https://doi.org/10.1182/blood-2014-05-577825
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
