Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease

Vichinsky, E. P., Neumayr, L. D., Earles, A. N., Williams, R., Lennette, E. T., Dean, D., Nickerson, B., Orringer, E., McKie, V., Bellevue, R., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422502 · Cited by 1,234 · see citing works

Population Estimates of Sickle Cell Disease in the U.S.

Hassell, K. L. (2010) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2009.12.022 · Cited by 1,214 · see citing works

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

Piel, F. B., Patil, A. P., Howes, R. E., Nyangiri, O. A., Gething, P. W., Dewi, M., Temperley, W. H., Williams, T. N., Weatherall, D. J., & Hay, S. I. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61229-x · Cited by 1,196 · see citing works

The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain

Kelly, A.-M. (2001) · Emergency Medicine Journal · doi:10.1136/emj.18.3.205 · Cited by 969 · see citing works

Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

Steinberg, M. H., Barton, F. B., Castro, O. L., Pegelow, C. H., Ballas, S. K., Kutlar, A., Orringer, E. P., Bellevue, R., Olivieri, N. F., Eckman, J. R., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1645 · Cited by 928 · see citing works

The inherited diseases of hemoglobin are an emerging global health burden

Weatherall, D. J. (2010) · Blood · doi:10.1182/blood-2010-01-251348 · Cited by 908 · see citing works

Acute Care Utilization and Rehospitalizations for Sickle Cell Disease

Brousseau, D. C. (2010) · JAMA · doi:10.1001/jama.2010.378 · Cited by 636 · see citing works

Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm

Turhan, A., Weiss, L. A., Mohandas, N., Coller, B. S., & Frenette, P. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052522799 · Cited by 487 · see citing works

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Manwani, D., & Frenette, P. S. (2013) · Blood · doi:10.1182/blood-2013-05-498311 · Cited by 428 · see citing works

The cost of health care for children and adults with sickle cell disease

Kauf, T. L., Coates, T. D., Liu, H., Mody‐Patel, N., & Hartzema, A. G. (2009) · American Journal of Hematology · doi:10.1002/ajh.21408 · Cited by 388 · see citing works

Hospital readmission for adult acute sickle cell painful episodes: frequency, etiology, and prognostic significance

Ballas, S. K., & Lusardi, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20336 · Cited by 284 · see citing works

Sickle cell vaso-occlusion: multistep and multicellular paradigm

Frenette, P. S. (2002) · Current Opinion in Hematology · doi:10.1097/00062752-200203000-00003 · Cited by 275 · see citing works

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

Chang, J., Patton, J. T., Sarkar, A., Ernst, B., Magnani, J. L., & Frenette, P. S. (2010) · Blood · doi:10.1182/blood-2009-12-260513 · Cited by 238 · see citing works

Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

Gladwin, M. T. (2011) · JAMA · doi:10.1001/jama.2011.235 · Cited by 221 · see citing works

Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin.

Udani, M., Zen, Q., Cottman, M. J., Leonard, N., Jefferson, S., Daymont, C. B., Truskey, G. A., & Telen, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1204 · Cited by 214 · see citing works

Purified Poloxamer 188 for Treatment of Acute Vaso-occlusive Crisis of Sickle Cell Disease

Orringer, E. P., Casella, J. F., Ataga, K. I., Koshy, M., Adams-Graves, P. E., Luchtman‐Jones, L., Wun, T., Watanabe, M., Shafer, F. E., Kutlar, A., et al. (2001) · JAMA · doi:10.1001/jama.286.17.2099 · Cited by 196 · see citing works

Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion

Hines, P. C., Zen, Q., Burney, S. N., Shea, D. A., Ataga, K. I., Orringer, E. P., Telen, M. J., & Parise, L. V. (2003) · Blood · doi:10.1182/blood-2001-12-0289 · Cited by 180 · see citing works

Hospitalization rates and costs of care of patients with sickle‐cell anemia in the state of Maryland in the era of hydroxyurea

Lanzkron, S., Haywood, C., Segal, J. B., & Dover, G. J. (2006) · American Journal of Hematology · doi:10.1002/ajh.20703 · Cited by 122 · see citing works

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial

Qari, M. H., Jaouni, S. K. A., Alardawi, M. S., Fatani, H., Alsayes, F. M., Zografos, P., Alsaigh, M. A., Alalfi, A., Alamin, M. A., Gadi, A., et al. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-12-0718 · Cited by 122 · see citing works

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo

Zennadi, R., Moeller, B. J., Whalen, E. J., Batchvarova, M., Xu, K., Shan, S., Delahunty, M. D., Dewhirst, M. W., & Telen, M. J. (2007) · Blood · doi:10.1182/blood-2006-11-056101 · Cited by 118 · see citing works

Mechanism of CD47-induced α4β1 Integrin Activation and Adhesion in Sickle Reticulocytes

Brittain, J. E., Han, J., Ataga, K. I., Orringer, E. P., & Parise, L. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407631200 · Cited by 99 · see citing works

Risk factors for hospital readmission within 30 days: A new quality measure for children with sickle cell disease

Frei‐Jones, M. J., Field, J. J., & DeBaun, M. R. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21854 · Cited by 98 · see citing works

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium

Zennadi, R., Chien, A. C., Xu, K., Batchvarova, M., & Telen, M. J. (2008) · Blood · doi:10.1182/blood-2008-01-134346 · Cited by 80 · see citing works

Integrin-associated protein is an adhesion receptor on sickle red blood cells for immobilized thrombospondin

Brittain, J. E., Mlinar, K. J., Anderson, C., Orringer, E. P., & Parise, L. V. (2001) · Blood · doi:10.1182/blood.v97.7.2159 · Cited by 71 · see citing works

Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia

Wun, T., Styles, L., DeCastro, L., Telen, M. J., Kuypers, F., Cheung, A., Kramer, W., Flanner, H., Rhee, S., Magnani, J. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101301 · Cited by 69 · see citing works

Erythrocyte plasma membrane–bound ERK1/2 activation promotes ICAM-4–mediated sickle red cell adhesion to endothelium

Zennadi, R., Whalen, E. J., Soderblom, E. J., Alexander, S. C., Thompson, J. W., Dubois, L. G., Moseley, M. A., & Telen, M. J. (2011) · Blood · doi:10.1182/blood-2011-03-344440 · Cited by 65 · see citing works

Refining the value of secretory phospholipase A 2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study ( PROACTIVE )

Styles, L. A., Wager, C. G., Labotka, R., Smith‐Whitley, K., Thompson, A. A., Lane, P. A., McMahon, L. C., Miller, R. E., Roseff, S. D., Iyer, R. V., et al. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09105.x · Cited by 53 · see citing works

Multi‐modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30‐day readmission rate

Frei‐Jones, M. J., Field, J. J., & DeBaun, M. R. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22048 · Cited by 32 · see citing works

Identification of the Ca2+ entry pathway involved in deoxygenation-induced phosphatidylserine exposure in red blood cells from patients with sickle cell disease

Cytlak, U., Hannemann, A., Rees, D. C., & Gibson, J. S. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1308-y · Cited by 26 · see citing works

Clinically Significant Differences in the Visual Analog Pain Scale in Acute Vasoocclusive Sickle Cell Crisis

Lopez, B. L., Flenders, P., Davis‐Moon, L., Corbin, T. J., & Ballas, S. K. (2007) · Hemoglobin · doi:10.1080/03630260701587810 · Cited by 24 · see citing works

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium

Trinh‐Trang‐Tan, M., Vilela-Lamego, C., Picot, J., Wautier, M.-P., & Cartron, J. (2009) · Haematologica · doi:10.3324/haematol.2009.017392 · Cited by 20 · see citing works

Correction: Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia

Staff, T. P. O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111690 · Cited by 11 · see citing works

GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease

Styles, L. A., Wun, T., Castro, L. M. D., Telen, M. J., Kramer, W. G., Flanner, H., Magnani, J. L., & Thackray, H. M. (2010) · Blood · doi:10.1182/blood.v116.21.1632.1632 · Cited by 9 · see citing works

Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study

Wun, T., Castro, L. M. D., Styles, L. A., Cheung, A., Chase, S., Simon, S. I., Magnani, J. L., & Thackray, H. M. (2010) · Blood · doi:10.1182/blood.v116.21.262.262 · Cited by 8 · see citing works

Biological roles of glycans

Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works

Sickle-cell disease

Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504 · see citing works

Sickle cell disease

Kato, G. J., Piel, F. B., Reid, C. D., Gaston, M. H., Ohene-Frempong, K., Krishnamurti, L., Smith, W. R., Panepinto, J. A., Weatherall, D. J., Costa, F. F., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.10 · Cited by 1,501 · see citing works

Sickle cell disease

Ware, R. E., de Montalembert, M., Tshilolo, L. M., & Abboud, M. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30193-9 · Cited by 1,004 · see citing works

Neutrophils as emerging therapeutic targets

Németh, T., Sperandio, M., & Mócsai, A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0054-z · Cited by 657 · see citing works

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

McEver, R. P. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv154 · Cited by 575 · see citing works

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

Mereiter, S., Balmaña, M., Campos, D., Gomes, J., & Reis, C. A. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.06.006 · Cited by 564 · see citing works

Sickle Cell Disease

Kavanagh, P. L., Fasipe, T., & Wun, T. (2022) · JAMA · doi:10.1001/jama.2022.10233 · Cited by 507 · see citing works

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

Smith, B. A. H., & Bertozzi, C. R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00093-1 · Cited by 504 · see citing works

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood · doi:10.1182/blood-2015-09-618538 · Cited by 413 · see citing works

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

Kudelka, M. R., Stowell, S. R., Cummings, R. D., & Neish, A. S. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0331-7 · Cited by 356 · see citing works

Inflammation in sickle cell disease

Conran, N., & Belcher, J. D. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189012 · Cited by 305 · see citing works

Targeting Glycosylation: A New Road for Cancer Drug Discovery

Costa, A. F., Campos, D., Reis, C. A., & Gomes, C. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.04.002 · Cited by 261 · see citing works

The vaso‐occlusive pain crisis in sickle cell disease: Definition, pathophysiology, and management

Darbari, D. S., Sheehan, V., & Ballas, S. K. (2020) · European Journal Of Haematology · doi:10.1111/ejh.13430 · Cited by 256 · see citing works

Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases

Li, J., Hsu, H.-C., Mountz, J. D., & Allen, J. G. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2018.02.005 · Cited by 256 · see citing works

Treating sickle cell disease by targeting HbS polymerization

Eaton, W. A., & Bunn, H. F. (2017) · Blood · doi:10.1182/blood-2017-02-765891 · Cited by 255 · see citing works

Recent insights into structures and functions of C-type lectins in the immune system

Drickamer, K., & Taylor, M. E. (2015) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2015.06.003 · Cited by 250 · see citing works

GBT 440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

Oksenberg, D., Dufu, K., Patel, M. P., Chuang, C.-Y., Li, Z., Xu, Q. R., Silva‐Garcia, A., Zhou, C., Hutchaleelaha, A., Patskovska, L. N., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.14214 · Cited by 244 · see citing works

Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group

Cramer, J., Sager, C. P., & Ernst, B. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00179 · Cited by 243 · see citing works

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation

Morla, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081963 · Cited by 214 · see citing works

Recent Advances in the Treatment of Sickle Cell Disease

Cisneros, G. S., & Thein, S. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00435 · Cited by 204 · see citing works

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

Merle, N. S., Grünenwald, A., Rajaratnam, H., Gnemmi, V., Frimat, M., Figueres, L., Knockaert, S., Bouzekri, S., Charue, D., Noé, R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96910 · Cited by 190 · see citing works

The role of neutrophils in thrombosis

Kapoor, S., Opneja, A., & Nayak, L. V. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.08.005 · Cited by 190 · see citing works

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

Telen, M. J., Malik, P., & Vercellotti, G. M. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0003-2 · Cited by 184 · see citing works

Crises in Sickle Cell Disease

Novelli, E. M., & Gladwin, M. T. (2015) · CHEST Journal · doi:10.1016/j.chest.2015.12.016 · Cited by 166 · see citing works

Sickle Cell Anemia and Its Phenotypes

Williams, T. N., & Thein, S. L. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021320 · Cited by 151 · see citing works

“Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling”

Cummings, R. D. (2019) · Glycoconjugate Journal · doi:10.1007/s10719-019-09876-0 · Cited by 146 · see citing works

Glycobiology simplified: diverse roles of glycan recognition in inflammation

Schnaar, R. L. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0116-021r · Cited by 141 · see citing works

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli

Bennewitz, M. F., Jimenez, M. A., Vats, R., Tutuncuoglu, E., Jonassaint, J., Kato, G. J., Gladwin, M. T., & Sundd, P. (2017) · JCI Insight · doi:10.1172/jci.insight.89761 · Cited by 139 · see citing works

Glycomimetics for the inhibition and modulation of lectins

Leusmann, S., Ménová, P., Shanina, E., Titz, A., & Rademacher, C. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00954d · Cited by 135 · see citing works

Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease

Telen, M. J. (2016) · Blood · doi:10.1182/blood-2015-09-618553 · Cited by 134 · see citing works

The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation

Xu, C., Lee, S. K., Zhang, D., & Frenette, P. S. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.025 · Cited by 131 · see citing works

Strategies for the Development of Glycomimetic Drug Candidates

Hevey, R. (2019) · Pharmaceuticals · doi:10.3390/ph12020055 · Cited by 124 · see citing works

Microvascular thrombosis: experimental and clinical implications

Bray, M. A., Sartain, S. E., Gollamudi, J., & Rumbaut, R. E. (2020) · Translational research · doi:10.1016/j.trsl.2020.05.006 · Cited by 119 · see citing works

Heparin Mimetics: Their Therapeutic Potential

Mohamed, S., & Coombe, D. R. (2017) · Pharmaceuticals · doi:10.3390/ph10040078 · Cited by 112 · see citing works

Advances in the Treatment of Sickle Cell Disease

Kapoor, S., Little, J. A., & Pecker, L. H. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.08.001 · Cited by 104 · see citing works

Sickle cell disease: Clinical presentation and management of a global health challenge

Houwing, M. E., de Pagter, P. J., van Beers, E. J., Biemond, B. J., Rettenbacher, E., Rijneveld, A. W., Schols, E. M., Philipsen, J. N. J., Tamminga, R. Y. J., van Draat, K. F., et al. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.05.004 · Cited by 101 · see citing works

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

Morikis, V. A., Chase, S., Wun, T., Chaikof, E. L., Magnani, J. L., & Simon, S. I. (2017) · Blood · doi:10.1182/blood-2017-05-783027 · Cited by 98 · see citing works

Emerging disease-modifying therapies for sickle cell disease

Carden, M. A., & Little, J. A. (2019) · Haematologica · doi:10.3324/haematol.2018.207357 · Cited by 97 · see citing works

Vaso-occlusive crisis in sickle cell disease: a vicious cycle of secondary events

Jang, T., Poplawska, M., Cimpeanu, E., Mo, G., Dutta, D., & Lim, S. H. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03074-z · Cited by 97 · see citing works

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches

Angata, T., Nycholat, C. M., & Macauley, M. S. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.06.008 · Cited by 97 · see citing works

Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review

Tvaroška, I., Selvaraj, C., & Koča, J. (2020) · Molecules · doi:10.3390/molecules25122835 · Cited by 93 · see citing works

Selectins and Immune Cells in Acute Myocardial Infarction and Post-infarction Ventricular Remodeling: Pathophysiology and Novel Treatments

Weil, B. R., & Neelamegham, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00300 · Cited by 88 · see citing works

Sialic acid and biology of life: An introduction

Ghosh, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816126-5.00001-9 · Cited by 88 · see citing works

Sickle Cell Disease

Azar, S., & Wong, T. E. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.09.009 · Cited by 86 · see citing works

End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain

Farrell, A. T., Panepinto, J. A., Carroll, C. P., Darbari, D. S., Desai, A. A., King, A. A., Adams, R. J., Barber, T. D., Brandow, A. M., DeBaun, M. R., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000882 · Cited by 84 · see citing works

Ischemia-Reperfusion Injury in Sickle Cell Disease

Ansari, J., & Gavins, F. N. E. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.12.012 · Cited by 78 · see citing works

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Wagner, S., Hauck, D., Hoffmann, M., Sommer, R., Joachim, I., Müller, R., Imberty, A., Varrot, A., & Titz, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201709368 · Cited by 77 · see citing works

Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease

Alapan, Y., Kim, C., Adhikari, A., Gray, K. E., Gürkan-Çavusoglu, E., Little, J. A., & Gurkan, U. A. (2016) · Translational research · doi:10.1016/j.trsl.2016.03.008 · Cited by 76 · see citing works

Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle

Dehghani, T., & Panitch, A. (2020) · Open Biology · doi:10.1098/rsob.200161 · Cited by 73 · see citing works

Innate immune cells, major protagonists of sickle cell disease pathophysiology

Allali, S., Maciel, T. T., Hermine, O., & de Montalembert, M. (2020) · Haematologica · doi:10.3324/haematol.2019.229989 · Cited by 72 · see citing works

Mammalian sugar‐binding receptors: known functions and unexplored roles

Taylor, M. E., & Drickamer, K. (2019) · FEBS Journal · doi:10.1111/febs.14759 · Cited by 67 · see citing works

Emerging point-of-care technologies for sickle cell disease screening and monitoring

Alapan, Y., Fraiwan, A., Kucukal, E., Hasan, M. N., Ung, R., Kim, M., Odame, I., Little, J. A., & Gurkan, U. A. (2016) · Expert Review of Medical Devices · doi:10.1080/17434440.2016.1254038 · Cited by 63 · see citing works

Pediatric sickle cell disease: past successes and future challenges

Meier, E. R., & Rampersad, A. G. (2016) · Pediatric Research · doi:10.1038/pr.2016.204 · Cited by 59 · see citing works

A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis

Wong, D. J., Park, D., Park, S. J., Haller, C. A., Chen, J., Dai, E., Liu, L., Mandhapati, A. R., Eradi, P., Dhakal, B., et al. (2021) · Blood · doi:10.1182/blood.2020009428 · Cited by 53 · see citing works

Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell‐induced vaso‐occlusion

Telen, M. J., Batchvarova, M., Shan, S., Bovée‐Geurts, P. H. M., Zennadi, R., Leitgeb, A. M., Brock, R. E., & Lindgren, M. (2016) · British Journal of Haematology · doi:10.1111/bjh.14303 · Cited by 53 · see citing works

THE EVOLVING PHARMACOTHERAPEUTIC LANDSCAPE FOR THE TREATMENT OF SICKLE CELL DISEASE

Ballas, S. K. (2020) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2020.010 · Cited by 52 · see citing works

How I treat the older adult with sickle cell disease

Thein, S. L., & Howard, J. (2018) · Blood · doi:10.1182/blood-2018-03-818161 · Cited by 51 · see citing works

2015 Clinical trials update in sickle cell anemia

Archer, N. M., Galactéros, F., & Brugnara, C. (2015) · American Journal of Hematology · doi:10.1002/ajh.24116 · Cited by 48 · see citing works

Patrolling monocytes scavenge endothelial-adherent sickle RBCs: a novel mechanism of inhibition of vaso-occlusion in SCD

Liu, Y., Zhong, H., Bao, W., Mendelson, A., An, X., Shi, P. A., Chou, S. T., Manwani, D. G., & Yazdanbakhsh, K. (2019) · Blood · doi:10.1182/blood.2019000172 · Cited by 48 · see citing works

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Bartneck, M., Schlößer, C. T., Barz, M., Zentel, R., Trautwein, C., Lammers, T., & Tacke, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04630 · Cited by 47 · see citing works

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

Lombardi, E., Mattè, A., Risitano, A. M., Ricklin, D., Lambris, J. D., Zanet, D. D., Jokiranta, S. T., Martinelli, N., Scambi, C., Salvagno, G. L., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.198622 · Cited by 45 · see citing works

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Dampier, C., Telen, M. J., Wun, T., Brown, C., Desai, P. C., Rassi, F. A. E., Fuh, B., Kanter, J., Pastore, Y. D., Rothman, J., et al. (2022) · Blood · doi:10.1182/blood.2022015797 · Cited by 45 · see citing works

Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome

Patel, M. S., Miranda-Nieves, D., Chen, J., Haller, C. A., & Chaikof, E. L. (2016) · Translational research · doi:10.1016/j.trsl.2016.11.007 · Cited by 44 · see citing works

Measuring success: utility of biomarkers in sickle cell disease clinical trials and care

Kalpatthi, R. V., & Novelli, E. M. (2018) · Hematology · doi:10.1182/asheducation-2018.1.482 · Cited by 44 · see citing works

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell, V., Varzakas, T. H., Ψαλτοπούλου, Θ., & Fernandes, T. H. (2024) · Nutrients · doi:10.3390/nu16020258 · Cited by 43 · see citing works

Drug Therapies for the Management of Sickle Cell Disease

Rai, P., & Ataga, K. I. (2020) · F1000Research · doi:10.12688/f1000research.22433.1 · Cited by 43 · see citing works

Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels

Morikis, V. A., & Simon, S. I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02774 · Cited by 42 · see citing works

NEW THERAPEUTIC OPTIONS FOR THE TREATMENT OF SICKLE CELL DISEASE

Mattè, A., Mazzi, F., Federti, E., Olivieri, O., & Franceschi, L. D. (2019) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2019.002 · Cited by 42 · see citing works

Emerging therapies in sickle cell disease

Nardo‐Marino, A., Brousse, V. A. M., & Rees, D. C. (2020) · British Journal of Haematology · doi:10.1111/bjh.16504 · Cited by 42 · see citing works

P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab

Karki, N. R., & Kutlar, A. (2021) · Journal of Pain Research · doi:10.2147/jpr.s278285 · Cited by 40 · see citing works

Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation

Escopy, S., & Chaikof, E. L. (2024) · Blood Vessels Thrombosis & Hemostasis · doi:10.1016/j.bvth.2024.100015 · Cited by 39 · see citing works

An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells

Ali, A. J., Abuelela, A. F., & Merzaban, J. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00492 · Cited by 39 · see citing works

Pathophysiology and recent therapeutic insights of sickle cell disease

Shah, F., & Dwivedi, M. (2020) · Annals of Hematology · doi:10.1007/s00277-020-03977-9 · Cited by 39 · see citing works

Pain in sickle cell disease: current and potential translational therapies

Sagi, V., Mittal, A., Tran, H., & Gupta, K. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.007 · Cited by 38 · see citing works

Pain and sickle cell disease

Aich, A., Jones, M. K., & Gupta, K. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000491 · Cited by 37 · see citing works

Sevuparin for the treatment of acute pain crisis in patients with sickle cell disease: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Biemond, B. J., Tombak, A., Kılınç, Y., Al-Khabori, M. K., Abboud, M. R., Nafea, M., Inati, A. C., Wali, Y. A. M. S., Kristensen, J. H., Kowalski, J. H., et al. (2021) · The Lancet Haematology · doi:10.1016/s2352-3026(21)00053-3 · Cited by 37 · see citing works

PF ‐04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo‐Controlled Study

Charnigo, R. J., Beidler, D. R., Rybin, D. V., Pittman, D. D., Tan, B., Howard, J., Michelson, A. D., Frelinger, A. L., & Clarke, N. P. (2018) · Clinical and Translational Science · doi:10.1111/cts.12604 · Cited by 36 · see citing works

New insights into sickle cell disease

Kato, G. J. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000241 · Cited by 36 · see citing works

Novel insights in the management of sickle cell disease in childhood

Iughetti, L. (2016) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v5.i1.25 · Cited by 35 · see citing works

New insights into the pathophysiology and development of novel therapies for sickle cell disease

Moerdler, S., & Manwani, D. G. (2018) · Hematology · doi:10.1182/asheducation-2018.1.493 · Cited by 35 · see citing works

Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction

Nader, É., Conran, N., Romana, M., & Connes, P. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200024 · Cited by 35 · see citing works

Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example

Badr, H. A., AlSadek, D. M. M., El-Houseini, M. E., Saeui, C. T., Mathew, M. P., Yarema, K. J., & Ahmed, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.044 · Cited by 34 · see citing works

Emerging pharmacotherapeutic approaches for the management of sickle cell disease

Torres, L. S., & Conran, N. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1548610 · Cited by 33 · see citing works

The trials and hopes for drug development in sickle cell disease

Ataga, K. I., & Stocker, J. W. (2015) · British Journal of Haematology · doi:10.1111/bjh.13548 · Cited by 32 · see citing works

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease

Kim, K., Li, J., Barazia, A., Tseng, A., Youn, S., Abbadessa, G., Yu, Y., Schwartz, B. E., Andrews, R. K., Gordeuk, V. R., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.151159 · Cited by 30 · see citing works

Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults

Cooper, T. E., Hambleton, I. R., Ballas, S. K., Cashmore, B. A., & Wiffen, P. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012187.pub2 · Cited by 29 · see citing works

Sickle cell vaso-occlusion: The dialectic between red cells and white cells

Conran, N., & Embury, S. H. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211005392 · Cited by 29 · see citing works

VLA ‐4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow

White, J. U., Krishnamoorthy, S., Gupta, D., Lancelot, M. M., Moore, N., Sarnaik, S. A., Hobbs, W. E., Light, D. R., & Hines, P. C. (2016) · British Journal of Haematology · doi:10.1111/bjh.14158 · Cited by 29 · see citing works

Systematic Review of Crizanlizumab: A New Parenteral Option to Reduce Vaso‐occlusive Pain Crises in Patients with Sickle Cell Disease

Han, J., Saraf, S. L., & Gordeuk, V. R. (2020) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2409 · Cited by 29 · see citing works

State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease

Puri, L., Nottage, K. A., Hankins, J. S., & Anghelescu, D. L. (2017) · Pediatric Drugs · doi:10.1007/s40272-017-0263-z · Cited by 28 · see citing works

Sickle cell disease as a vascular disorder

Ofori-Acquah, S. F. (2020) · Expert Review of Hematology · doi:10.1080/17474086.2020.1758555 · Cited by 27 · see citing works

Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem

Aich, A., Lamarre, Y., Sacomani, D. P., Kashima, S. H., Covas, D. T., & de la Torre, L. G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.558982 · Cited by 27 · see citing works

Selectin-mediated leukocyte trafficking during the development of autoimmune disease

Angiari, S. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.06.006 · Cited by 27 · see citing works

Improved health care utilization and costs in transplanted versus non-transplanted adults with sickle cell disease

Saraf, S. L., Ghimire, K. B., Patel, P. R., Sweiss, K. I., Gowhari, M., Molokie, R. E., Gordeuk, V. R., & Rondelli, D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229710 · Cited by 25 · see citing works

Research in Sickle Cell Disease: From Bedside to Bench to Bedside

Cisneros, G. S., & Thein, S. L. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000584 · Cited by 25 · see citing works

Norovirus, glycans and attachment

Taube, S., Mallagaray, Á., & Peters, T. (2018) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.04.007 · Cited by 22 · see citing works

Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice

Barazia, A., Li, J., Kim, K., Shabrani, N. C., & Cho, J. (2015) · Blood · doi:10.1182/blood-2015-02-626234 · Cited by 22 · see citing works

Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy

Colomb, F., Giron, L. B., Kuri-Cervantes, L., Adeniji, O. S., Ma, T., Dweep, H., Battivelli, E., Verdin, E. M., Palmer, C. S., Tateno, H., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107991 · Cited by 22 · see citing works

Optimizing the care model for an uncomplicated acute pain episode in sickle cell disease

Telfer, P. T., & Kaya, B. (2017) · Hematology · doi:10.1182/asheducation-2017.1.525 · Cited by 21 · see citing works

GMI 1070: Reduction In Time To Resolution Of Vaso-Occlusive Crisis and Decreased Opioid Use In a Prospective, Randomized, Multi-Center Double Blind, Adaptive Phase 2 Study In Sickle Cell Disease

Telen, M. J., Wun, T., McCavit, T. L., Castro, L. M. D., Krishnamurti, L., Lanzkron, S., Hsu, L. L.-Y., Smith, W. R., Rhee, S., Magnani, J. L., et al. (2013) · Blood · doi:10.1182/blood.v122.21.776.776 · Cited by 8 · see citing works

American society of hematology: 55th annual meeting and exposition.

Alexander, W. (2014) · Europe PMC (PubMed Central)

Effects Of GMI 1070, a Pan-Selectin Inhibitor, On Pain Intensity and Opioid Utilization In Sickle Cell Disease

Castro, L. M. D., Wun, T., Lanzkron, S., Smith, W. R., Hassell, K. L., Kutlar, A., Smith‐Whitley, K., Rhee, S., Telen, M. J., & Thackray, H. M. (2013) · Blood · doi:10.1182/blood.v122.21.775.775 · Cited by 4 · see citing works

An Analysis Of The Pediatric Sub-Group From The Phase 2 Study Of GMI 1070 – A Novel Agent For The Vaso-Occlusive Crisis Of Sickle Cell Anemia

McCavit, T. L., Krishnamurti, L., Hsu, L. L.-Y., Quinn, C. T., Odame, I., Alvarez, O. A., Driscoll, C. E., Smith‐Whitley, K., Rhee, S., Wun, T., et al. (2013) · Blood · doi:10.1182/blood.v122.21.2206.2206 · Cited by 2 · see citing works

Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis

Wun, T., Telen, M. J., Krishnamurti, L., McCavit, T. L., DeCastro, L. M., Flanner, H., Kuypers, F. A., Larkin, S. K., Rhee, S., Magnani, J. L., et al. (2014) · Blood · doi:10.1182/blood.v124.21.2704.2704 · Cited by 6 · see citing works