DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia
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Key Points: Transcriptome and functional analyses reveal accelerated T-cell aging in ICL. Dampening of TCR signaling in ICL relies on DUSP4 overexpression.
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Increased expression of DUSP4 in T cells causes defective TCR responses and aging markers reminiscent of T-cell senescence.
“the increased expression in T cells of another dual specificity phosphatase, DUSP4, was also found to cause defective TCR responses and aging markers reminiscent of T-cell senescence [83].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [83]
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- Authors
- Bignon, A., Régent, A., Klipfel, L., Desnoyer, A., de la Grange, P., Martinez, V., Lortholary, O., Dalloul, A., Mouthon, L., & Balabanian, K.
- Affiliations
- Université Paris-Sud (FR)
- Centre National de la Recherche Scientifique (FR)
- GenoSplice, Hôpital Pitié-Salpêtrière, Paris, France;
- Hôpital Necker-Enfants Malades (FR)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-04-16
- Volume
- 125
- Issue
- 16
- Pages
- 2507-2518
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2029343618
- Cited by
- 51
- References
- 63
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0003, ANR-10-LABX-0017, ANR-10-JCJC-1104, ANR-10-LABX-0033)
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- DUSP4, T cell senescence, T cell receptor signaling, ERK activation, CD4+ T cells, memory T cells, CD27, CD40 ligand, chronic immune activation, siRNA knockdown, opportunistic infections, vaccine response
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Flow Cytometry, Humans, Lymphocyte Activation, Lymphopenia, Male, Middle Aged, Receptors, Antigen, T-Cell, T-Lymphocytes, CD4-Positive T-Lymphocytes, Immunophenotyping, Cellular Senescence, CD4 Lymphocyte Count, Oligonucleotide Array Sequence Analysis, RNA Interference, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases, Young Adult, Transcriptome
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