Cited by 51T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersHIV Research and Treatment

DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia

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Bignon, Alexandre, Régent, Alexis, Klipfel, Laurence, Desnoyer, Aude, de la Grange, Pierre, Martinez, Valérie, Lortholary, Olivier, Dalloul, Ali +2 more·2015·Blood

Abstract

Key Points: Transcriptome and functional analyses reveal accelerated T-cell aging in ICL. Dampening of TCR signaling in ICL relies on DUSP4 overexpression.

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Crossref · 10.1182/blood-2014-08-598565

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  • Increased expression of DUSP4 in T cells causes defective TCR responses and aging markers reminiscent of T-cell senescence.

    “the increased expression in T cells of another dual specificity phosphatase, DUSP4, was also found to cause defective TCR responses and aging markers reminiscent of T-cell senescence [83].”

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Authors
Bignon, A., Régent, A., Klipfel, L., Desnoyer, A., de la Grange, P., Martinez, V., Lortholary, O., Dalloul, A., Mouthon, L., & Balabanian, K.
Affiliations
  • Université Paris-Sud (FR)
  • Centre National de la Recherche Scientifique (FR)
  • GenoSplice, Hôpital Pitié-Salpêtrière, Paris, France;
  • Hôpital Necker-Enfants Malades (FR)
Venue
Blood
Published
2015-04-16
Volume
125
Issue
16
Pages
2507-2518
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2029343618
Cited by
51
References
63
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3
FWCI
2.30
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-11-IDEX-0003, ANR-10-LABX-0017, ANR-10-JCJC-1104, ANR-10-LABX-0033)
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
DUSP4, T cell senescence, T cell receptor signaling, ERK activation, CD4+ T cells, memory T cells, CD27, CD40 ligand, chronic immune activation, siRNA knockdown, opportunistic infections, vaccine response
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Flow Cytometry, Humans, Lymphocyte Activation, Lymphopenia, Male, Middle Aged, Receptors, Antigen, T-Cell, T-Lymphocytes, CD4-Positive T-Lymphocytes, Immunophenotyping, Cellular Senescence, CD4 Lymphocyte Count, Oligonucleotide Array Sequence Analysis, RNA Interference, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases, Young Adult, Transcriptome

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