The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
Open accessAbstract
Key Points: Telomerase gene therapy in a mouse model of aplastic anemia targets the bone marrow and provides increased and stable telomerase expression. Telomerase expression leads to telomere elongation and subsequently to the reversal of aplastic anemia phenotypes.
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“At least two mouse models have demonstrated a causative role of telomere dysfunction in bone marrow failure.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“Similarly, transplantation of bone marrow from late-generation Tert-knockout mice in irradiated wild-type recipients resulted in aplastic anaemia85.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“In both models, danazol or AAV-mediated Tert expression improved haematopoiesis85,86.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“As an example, telomerase activation using a gene therapy strategy has shown therapeutic effects on mouse models of pulmonary fibrosis, and aplastic anemia 44,46 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [46]
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,158
Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 814
Inagaki, K., Fuess, S., Storm, T. A., Gibson, G. A., Mctiernan, C. F., Kay, M. A., & Nakai, H. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.014 · Cited by 610
Telomere and telomerase in stem cells
Hiyama, E., & Hiyama, K. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603671 · Cited by 573
Guidelines for the diagnosis and management of aplastic anaemia
Marsh, J. C. W., Ball, S. E., Cavenagh, J. D., Darbyshire, P. J., Dokal, I. S., Gordon‐Smith, E. C., Keidan, J., Laurie, A., Martín, A., Mercieca, J., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07842.x · Cited by 557
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548
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Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Self-citationTelomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257
“Indeed, by using the mouse preclinical model of aplastic anemia provoked by short telomeres in the BM, we demonstrate that AVV9-Tert rescues aplastic anemia and mouse survival by inducing telomere lengthening in peripheral blood and BM cells as well as increasing blood counts (Bär et al., 2016).”
Self-citationArtificial intelligence for aging and longevity research: Recent advances and perspectives
Zhavoronkov, A., Mamoshina, P., Vanhaelen, Q., Scheibye-Knudsen, M., Moskalev, A., & Aliper, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.003 · Cited by 246
“Telomerase gene therapy is a possible therapeutic intervention against aging and age‐related diseases (Boccardi and Herbig, 2012; Bär et al., 2016; Muñoz-Lorente et al., 2018).”
Targeting immune dysfunction in aging
Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 232
Metadata
- Authors
- Bär, C., Povedano, J. M., Serrano, R., Benitez-Buelga, C., Popkes, M., Formentini, I., Bobadilla, M., Bosch, F., & Blasco, M. A.
- Affiliations
- Telomeres and Telomerase Group, Molecular Oncology Program and
- Human Genetics Group, Spanish National Cancer Research Centre, Madrid, Spain;
- Roche Pharma Research and Early Development, Neuroscience, Ophthalmology, and Rare Disease, Roche Innovation Center and
- Roche Extending the Innovation Network Academia Partnering Program, F. Hoffmann-La Roche, Basel, Switzerland; and
- Centre of Animal Biotechnology and Gene Therapy, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-04-07
- Volume
- 127
- Issue
- 14
- Pages
- 1770-1779
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2279382765
- Cited by
- 116
- References
- 42
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 14 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, other-oa)
- Funders
- Ministerio de Economía y Competitividad
- Fundación Botín
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- aplastic anemia, telomerase reverse transcriptase, telomere shortening, AAV9, hematopoietic stem cells, bone marrow aplasia, pancytopenia, bone marrow hypoplasia
- MeSH terms
- Dependovirus, Anemia, Aplastic, Animals, Disease Models, Animal, Hematopoietic Stem Cells, Transduction, Genetic, Genetic Therapy, Telomere, Mice, Knockout, Telomerase, Mice, Telomere Homeostasis
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