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Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
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Key Points: Telomerase gene therapy in a mouse model of aplastic anemia targets the bone marrow and provides increased and stable telomerase expression. Telomerase expression leads to telomere elongation and subsequently to the reversal of aplastic anemia phenotypes.
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“At least two mouse models have demonstrated a causative role of telomere dysfunction in bone marrow failure.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“Similarly, transplantation of bone marrow from late-generation Tert-knockout mice in irradiated wild-type recipients resulted in aplastic anaemia85.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“In both models, danazol or AAV-mediated Tert expression improved haematopoiesis85,86.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“As an example, telomerase activation using a gene therapy strategy has shown therapeutic effects on mouse models of pulmonary fibrosis, and aplastic anemia 44,46 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [46]
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,139
Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 814
Inagaki, K., Fuess, S., Storm, T. A., Gibson, G. A., Mctiernan, C. F., Kay, M. A., & Nakai, H. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.014 · Cited by 610
Telomere and telomerase in stem cells
Hiyama, E., & Hiyama, K. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603671 · Cited by 573
Guidelines for the diagnosis and management of aplastic anaemia
Marsh, J. C. W., Ball, S. E., Cavenagh, J. D., Darbyshire, P. J., Dokal, I. S., Gordon‐Smith, E. C., Keidan, J., Laurie, A., Martín, A., Mercieca, J., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07842.x · Cited by 557
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548
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Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Self-citationTelomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257
“Indeed, by using the mouse preclinical model of aplastic anemia provoked by short telomeres in the BM, we demonstrate that AVV9-Tert rescues aplastic anemia and mouse survival by inducing telomere lengthening in peripheral blood and BM cells as well as increasing blood counts (Bär et al., 2016).”
Self-citationArtificial intelligence for aging and longevity research: Recent advances and perspectives
Zhavoronkov, A., Mamoshina, P., Vanhaelen, Q., Scheibye-Knudsen, M., Moskalev, A., & Aliper, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.003 · Cited by 246
“Telomerase gene therapy is a possible therapeutic intervention against aging and age‐related diseases (Boccardi and Herbig, 2012; Bär et al., 2016; Muñoz-Lorente et al., 2018).”
Targeting immune dysfunction in aging
Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 232
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Muñoz-Lorente, M. A., Cano-Martin, A. C., & Blasco, M. A. (2019) · Nature Communications · doi:10.1038/s41467-019-12664-x · Cited by 184
Self-citationPovedano, J. M., Martinez, P., Serrano, R., Tejera, Á., Gómez-López, G., Bobadilla, M., Flores, J. M., Bosch, F., & Blasco, M. A. (2018) · eLife · doi:10.7554/elife.31299 · Cited by 139
Self-citationTherapeutic Targeting of Telomerase
Jäger, K., & Walter, M. (2016) · Genes · doi:10.3390/genes7070039 · Cited by 144
Aging impairs the neurovascular interface in the heart
Wagner, J. U. G., Tombor, L., Malacarne, P. F., Kettenhausen, L.-M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K. A., et al. (2023) · Science · doi:10.1126/science.ade4961 · Cited by 137
Self-citationMouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113
Pathogenesis of aplastic anemia
Wang, L., & Liu, H. (2019) · Hematology · doi:10.1080/16078454.2019.1642548 · Cited by 104
Short Telomere Syndromes in Clinical Practice: Bridging Bench and Bedside
Mangaonkar, A. A., & Patnaik, M. M. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.03.020 · Cited by 99
Kam, M. L. W., Nguyen, T. T. T., & Ngeow, J. Y. Y. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00198-5 · Cited by 84
Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963054 · Cited by 79
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
Yuan, X., & Xu, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133338 · Cited by 75
Martínez, P., & Blasco, M. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312202 · Cited by 74
Self-citationWhittemore, K., Derevyanko, A., Martinez, P., Serrano, R., Pumarola, M., Bosch, F., & Blasco, M. A. (2019) · Aging · doi:10.18632/aging.101982 · Cited by 69
Self-citationAdeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy
Zwi‐Dantsis, L., Mohamed, S., Massaro, G., & Moeendarbary, E. (2025) · Viruses · doi:10.3390/v17020239 · Cited by 68
Unlocking longevity: the role of telomeres and its targeting interventions
Schellnegger, M., Hofmann, E., Carnieletto, M., & Kamolz, L. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1339317 · Cited by 65
Telomere function and regulation from mouse models to human ageing and disease
Jones-Weinert, C. W., Mainz, L., & Karlseder, J. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00800-5 · Cited by 63
Gene Therapy Strategies Targeting Aging-Related Diseases
Yu, J., Li, T., & Zhu, J. (2022) · Aging and Disease · doi:10.14336/ad.2022.00725 · Cited by 53
Telomeres as Therapeutic Targets in Heart Disease
Yeh, J.-K., Lin, M.-H., & Wang, C.-Y. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.009 · Cited by 49
The Importance of Telomere Shortening for Atherosclerosis and Mortality
Herrmann, W., & Herrmann, M. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7030029 · Cited by 47
Telomere Shortening and Its Association with Cell Dysfunction in Lung Diseases
Ruíz, A., Flores‐González, J., Buendía-Roldán, I., & Chávez‐Galán, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010425 · Cited by 46
Telomerase: A prominent oncological target for development of chemotherapeutic agents
Vishwakarma, K., Dey, R., & Bhatt, H. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115121 · Cited by 44
p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita
Fok, W. C., Niero, E. L. D. O., Dege, C., Brenner, K. A., Sturgeon, C. M., & Batista, L. F. Z. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.015 · Cited by 40
Derevyanko, A., Whittemore, K., Schneider, R. P., Jiménez, V., Bosch, F., & Blasco, M. A. (2017) · Aging Cell · doi:10.1111/acel.12677 · Cited by 42
Self-citationMuñoz-Lorente, M. A., Martínez, P., Tejera, Á., Whittemore, K., Moisés-Silva, A. C., Bosch, F., & Blasco, M. A. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007562 · Cited by 40
Self-citationTeissier, T., Temkin, V., Pollak, R. D., & Cox, L. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.812157 · Cited by 35
Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases
Hong, J., & Yun, C. (2019) · Cells · doi:10.3390/cells8050392 · Cited by 33
Karnewar, S., Karnewar, V., Shankman, L. S., & Owens, G. K. (2024) · JCI Insight · doi:10.1172/jci.insight.173863 · Cited by 36
Short and dysfunctional telomeres sensitize the kidneys to develop fibrosis
Saraswati, S., Martínez, P., Graña-Castro, O., & Blasco, M. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00040-8 · Cited by 28
Self-citationBarros, P. R., Costa, T. J. D., Akamine, E. H., & Tostes, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.727604 · Cited by 33
Du, Q. B., He, D., Zeng, H.-L., Liu, J., Yang, H., Xu, L., Liang, H., Wan, D., Tang, C., Cai, P., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113160 · Cited by 29
Denham, J. (2023) · Aging Cell · doi:10.1111/acel.13836 · Cited by 28
Religiosity, depression and telomere length in Chinese older adults
Wang, L., Koenig, H. G., Shohaib, S. A., & Wang, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.066 · Cited by 27
Advances in the gene therapy of monogenic blood cell diseases
Bueren, J. A., Bustamante, O. Q., Almarza, E., Navarro, S., Rı́o, P., Segovia, J. C., & Güenechea, G. (2019) · Clinical Genetics · doi:10.1111/cge.13593 · Cited by 28
Targeting immunosenescence for improved tumor immunotherapy
Liu, Z., Zuo, L., Zhou, Z., Liu, S., Ba, Y., Zuo, A., Ren, Y., Zhang, C., Chen, Y., Ma, H., et al. (2024) · MedComm · doi:10.1002/mco2.777 · Cited by 24
The association between telomere length and non-alcoholic fatty liver disease: a prospective study
Tang, L., Li, D., Ma, Y., Cui, F., Wang, J., & Tian, Y. (2023) · BMC Medicine · doi:10.1186/s12916-023-03136-7 · Cited by 26
Vieri, M., Brümmendorf, T. H., & Beier, F. (2021) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2021.101282 · Cited by 23
Multisystemic Manifestations in Rare Diseases: The Experience of Dyskeratosis Congenita
Callea, M., Martinelli, D., Cammarata-Scalisi, F., Grimaldi, C., Jilani, H., Grimaldi, P., Willoughby, C. E., & Morabito, A. (2022) · Genes · doi:10.3390/genes13030496 · Cited by 25
Eguchi, A., Gonzalez, A. F. G. S., Torres-Bigio, S. I., Koleckar, K., Birnbaum, F., Zhang, J. Z., Wang, V. Y., Wu, J. C., Artandi, S. E., & Blau, H. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209967120 · Cited by 24
Aplastic Anemia as a Roadmap for Bone Marrow Failure: An Overview and a Clinical Workflow
Solimando, A. G., Palumbo, C., Pragnell, M. V., Bittrich, M., Argentiero, A., & Krebs, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911765 · Cited by 26
Telomeres: Dysfunction, Maintenance, Aging and Cancer
Liao, P., Yan, B., Wang, C., & Lei, P. (2023) · Aging and Disease · doi:10.14336/ad.2023.1128 · Cited by 22
Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity
Chatterjee, S., de Gonzalo-Calvo, D., Derda, A. A., Schimmel, K., Sonnenschein, K., Bavendiek, U., Bauersachs, J., Bär, C., & Thum, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-29072-8 · Cited by 21
Self-citationIskandar, M., Barbero, M. X., Jaber, M. T., Chen, R., Gomez-Guevara, R., Cruz, E., & Westerheide, S. D. (2025) · Cancers · doi:10.3390/cancers17020257 · Cited by 30
Matsumoto, C., Jiang, Y., Emathinger, J. M., Quijada, P. J., Nguyen, N., Torre, A. D. L., Moshref, M., Nguyen, J. T., Levinson, A. B., Shin, M., et al. (2018) · Stem Cells · doi:10.1002/stem.2793 · Cited by 21
Critically short telomeres and toxicity of chemotherapy in early breast cancer
Quintela-Fandiño, M., Soberón, N. E., Lluch, A. M., Manso, L., Calvo, I., Cortés, J., Moreno-Antón, F., Gil‐Gil, M., Martínez-Jáñez, N., González-Martı́n, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15592 · Cited by 20
Self-citationChen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 27
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
Todorova, M. N., Savova, M. S., Mihaylova, L. V., & Georgiev, M. I. (2024) · Food Frontiers · doi:10.1002/fft2.350 · Cited by 17
Telomerase activation in the treatment of aging or degenerative diseases: a systematic review
Prieto-Oliveira, P. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03929-x · Cited by 16
Kamycheva, E., Goto, T., & Camargo, C. A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.003 · Cited by 15
Telomere dysfunction in chronic liver disease: The link from aging
Penrice, D. D., Jalan‐Sakrikar, N., Jurk, D., Passos, J. F., & Simonetto, D. A. (2023) · Hepatology · doi:10.1097/hep.0000000000000426 · Cited by 14
The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies
Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15
Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence
Hou, J., Yun, Y. J., Jeon, B.-M., Baek, J.-I., & Kim, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814241 · Cited by 16
Lewis, C. J., & de Grey, A. D. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2330425 · Cited by 10
A roadmap to precision treatments for familial pulmonary fibrosis
Hurley, K., Ozaki, M., Philippot, Q., Galvin, L., Crosby, D., Kirwan, M., Gill, D. R., Alysandratos, K., Jenkins, G. R., Griese, M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105135 · Cited by 10
Brancolini, A., Bobbili, M. R., Pultar, M., Mazidi, Z., Wieser, M., Gamauf, J., Roefs, M. T., Corso, G., Nivarthi, H., Arteaga, M. B., et al. (2026) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2026.03.010 · Cited by 12
The role of telomere binding molecules for normal and abnormal hematopoiesis
Hosokawa, K., & Arai, F. (2018) · International Journal of Hematology · doi:10.1007/s12185-018-2432-4 · Cited by 13
Tiendrébéogo, A. J. F., Soumagne, T., Pellegrin, F., Dagouassat, M., Nhieu, J. T. V., Caramelle, P., Paul, E. N., Even, B., Zysman, M., Julé, Y., et al. (2023) · Scientific Reports · doi:10.1038/s41598-022-25993-7 · Cited by 9
Hernández‐Silva, D., López-Abellán, M. D., Martínez-Navarro, F. J., García‐Castillo, J., Cayuela, M. L., & Alcaraz‐Pérez, F. (2025) · Aging Cell · doi:10.1111/acel.70007 · Cited by 10
Evolution of Telomerase Inhibitors: A Review on Key Patents from 2015 to 2023
Dey, R., Vishwakarma, K., Patel, B., Vyas, V. K., & Bhatt, H. (2024) · ChemistrySelect · doi:10.1002/slct.202404444 · Cited by 7
El‐Badry, M., Espinoza, J. L., & Nakao, S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2016.12.011 · Cited by 6
Familial pulmonary fibrosis: a world without frontiers
Borie, R., & Crestani, B. (2019) · Jornal Brasileiro de Pneumologia · doi:10.1590/1806-3713/e20190303 · Cited by 6
Mini review: Gene therapy targets for aging-associated diseases
Shchukina, E., Eremin, I. I., Mazunin, I., & Alexey, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152708 · Cited by 5
Dey, R., Patel, B., Vyas, V. K., Dixit, N., Patel, S., & Bhatt, H. (2025) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-025-00511-7 · Cited by 5
Hou, H. Y., Li, D., Yao, Y., Lü, J., Sun, Y.-N., Hu, Y., Wu, S., Chu, X., Xiao, P., Xu, G., et al. (2019) · Europe PMC (PubMed Central) · Cited by 5
Saad, F. A. (2024) · Current Gene Therapy · doi:10.2174/0115665232286489240320051925 · Cited by 5
Antiaging Strategies Based on Telomerase Activity
Aydin, Y. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9_7 · Cited by 4
Pîrlog, L.-M., Catana, A. M., Pitforodeschi, A.-D., Pilatec, A.-N., Băilă, R.-M., Rusu, I., Militaru, M.-S., Iordănescu, I. I., & Belbe, A.-A. (2026) · Genes · doi:10.3390/genes17060681 · Cited by 4
Oppezzo, A., Sepe, S., Cicio, G., Cancila, V., Sasso, E., Conti, A., Marinelli, E., Cabrini, M., Pallavi, R., Iacomino, N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01136-9 · Cited by 4
Klinaki, E., & Ogrodnik, M. B. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111929 · Cited by 3
Portillo, A. M., García-Velasco, J. A., & Varela, E. (2024) · Mathematical Biosciences · doi:10.1016/j.mbs.2024.109305 · Cited by 3
Telomerase modRNA Offers a Novel RNA ‐Based Approach to Treat Human Pulmonary Fibrosis
Ye, J. L., Grieger, K. M., Lu, D., Brandenberger, C., Juchem, M., Jordan, M., Oehlsen, L., Zardo, P., Werlein, C., Hesse, C., et al. (2025) · Aging Cell · doi:10.1111/acel.70240 · Cited by 3
Self-citationZhao, X.-C., Ju, B., Xiu, N.-N., Sun, X.-Y., & Meng, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1339971 · Cited by 4
Ng, G. Y. Q., & Hande, M. P. (2024) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2024.503773 · Cited by 2
Telomerase-Mediated Anti-Ageing Interventions
Dunn, P. L., Logeswaran, D., & Chen, J. J. ‐. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_1 · Cited by 2
Sabaie, H., Rad, A. T., Shabestari, M., Seddiq, S., Saadattalab, T., Habibi, D., Saeidian, A. H., Abbasi, M., & Mirtavoos‐Mahyari, H. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106277 · Cited by 2
Aspectos clínicos, etiológicos y terapéuticos de la disqueratosis congénita
Perona, R., Sastre, L., Callea, M., & Cammarata‐Scalisi, F. (2020) · Revista Peruana de Investigación en Salud · doi:10.35839/repis.4.2.606 · Cited by 2
Karnewar, S., Karnewar, V., Shankman, L. S., & Owens, G. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.12.548696 · Cited by 2
Hanley, S. M., Schutte, N. S., Bellamy, J., & Denham, J. (2025) · Journal of Intellectual Disability Research · doi:10.1111/jir.13244 · Cited by 1
Extracellular vesicles for delivery of functional telomerase
He, Y., Cui, Y., Wang, L., Yang, W., Wang, R., Li, Y., Ma, Y., Lin, Y., Wu, X., Cheng, L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02524-1 · Cited by 1
Gene therapy for aging: Current evidence and future directions
Zhang, Y. C., Gan, L., Wang, S., & Zhang, J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103144 · Cited by 1
He, M. Y., Lian, G., Hu, H., He, H., & Wang, M. (2023) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2022.344 · Cited by 1
Sokkar, M. F., Hamdy, M. M., Erian, P. S. F., Mosaad, R. M., Elaraby, N. M., Taher, M. B., El-Sayed, H. M., Komy, M. A., Eid, M. M., Mohamed, A. M., et al. (2023) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-023-00585-8 · Cited by 1
Portillo, A. M., García-Velasco, J. A., & Varela, E. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105577 · Cited by 1
Modelling severe paediatric aplastic anaemia using induced pluripotent stem cell technology
Melguizo‐Sanchis, D. (2017)
Telomeropathies: rare disease syndromes
Pańczyszyn, A., & Boniewska‐Bernacka, E. (2018) · MEDICAL SCIENCE PULSE · doi:10.5604/01.3001.0012.1165
[A real-world study of 176 cases with aplastic anemia treated in outpatient].
Zhang, L. L., Yu, X., Fang, L. W., Pan, H., Liang, Q., Zhao, J., Kuang, Z. X., & Shi, J. (2021) · PubMed Central · doi:10.3760/cma.j.issn.0253-2727.2021.01.011
Telomere and a Final Verdict for Cellular Senescence
Wynn, A. A., & Mya, N. K. (2020) · Borneo Journal of Medical Sciences (BJMS) · doi:10.51200/bjms.v14i3.2265
Perona, R., Manguán-García, C., & Sastre, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_41
Perona, R., Manguán-García, C., & Sastre, L. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_41-1
di Fagagna, F. D., & Rossiello, F. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736766076.793567264
Ageing impairs the neuro-vascular interface in the heartPreprint
Wagner, J. U. G., Tombor, L. S., Malacarne, P. F., Kettenhausen, L.-M., Panthel, J., Cipca, M., Stilz, K. A., Fischer, A., Muhly-Reinholz, M., Abplanalp, W. T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.29.501999
Self-citationMa, H., Wu, X., Li, Y., & Xia, Y. (2022) · Kompass Neumología · doi:10.1159/000526906
Pulmonary Fibrosis: One Manifestation, Various Diseases
Ruaro, B., Matucci‐Cerinic, M., Baratella, E., Confalonieri, M., Salton, F., & Hughes, M. (2022) · Frontiers research topics · doi:10.3389/978-2-83250-654-7
Relação das alterações da telomerase no desenvolvimento da Anemia Aplástica, uma revisão narrativa
Soares, D. R. L. D. S., da Silva, M. A., Soares, S. C., Filho, T. F. D. S., Nascimento, L. D. S., Martins, L. R. G., & de Oliveira, I. S. (2023) · Brazilian Journal of Development · doi:10.34117/bjdv9n1-182
Jia, H., Lin, Z. H., Li, W., Zhang, Z., & Liu, H. (2022) · PubMed Central · doi:10.3760/cma.j.issn.0253-2727.2022.07.010
Age-related disease: Cancer, telomerase, and cell aging
Whittemore, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00016-5
Metadata
- Authors
- Bär, C., Povedano, J. M., Serrano, R., Benitez-Buelga, C., Popkes, M., Formentini, I., Bobadilla, M., Bosch, F., & Blasco, M. A.
- Affiliations
- Telomeres and Telomerase Group, Molecular Oncology Program and
- Human Genetics Group, Spanish National Cancer Research Centre, Madrid, Spain;
- Roche Pharma Research and Early Development, Neuroscience, Ophthalmology, and Rare Disease, Roche Innovation Center and
- Roche Extending the Innovation Network Academia Partnering Program, F. Hoffmann-La Roche, Basel, Switzerland; and
- Centre of Animal Biotechnology and Gene Therapy, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-04-07
- Volume
- 127
- Issue
- 14
- Pages
- 1770-1779
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2279382765
- Cited by
- 116
- References
- 42
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 14 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, other-oa)
- Funders
- Ministerio de Economía y Competitividad
- Fundación Botín
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- aplastic anemia, telomerase reverse transcriptase, telomere shortening, AAV9, hematopoietic stem cells, bone marrow aplasia, pancytopenia, bone marrow hypoplasia
- MeSH terms
- Dependovirus, Anemia, Aplastic, Animals, Disease Models, Animal, Hematopoietic Stem Cells, Transduction, Genetic, Genetic Therapy, Telomere, Mice, Knockout, Telomerase, Mice, Telomere Homeostasis
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