Cited by 7,831Lymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia ResearchAcute Lymphoblastic Leukemia research

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

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Swerdlow, Steven H., Campo, Elias, Pileri, Stefano A., Harris, Nancy Lee, Stein, Harald, Siebert, Reiner, Advani, Ranjana, Ghielmini, Michele +3 more·2016·Blood

Abstract

A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

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Crossref · 10.1182/blood-2016-01-643569

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  1. [105]Parrilla Castellar ER, Jaffe ES, Said JW, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014;124(9):1473–1480. doi: 10.1182/blood-2014-04-571091. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI

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Authors
Swerdlow, S. H., Campo, E., Pileri, S. A., Harris, N. L., Stein, H., Siebert, R., Advani, R., Ghielmini, M., Salles, G. A., Zelenetz, A. D., & Jaffe, E. S.
Affiliations
  • University of Pittsburgh (US)
  • Department of Pathology, Hospital Clinic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain;
  • European Institute of Oncology (IT)
  • Harvard University (US)
  • Pathodiagnostik Berlin (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Stanford Medicine (US)
  • Istituto Oncologico della Svizzera Italiana (CH)
  • Lyon 1 Université (FR)
  • Memorial Sloan Kettering Cancer Center (US)
  • National Cancer Institute (US)
Venue
Blood
Published
2016-05-19
Volume
127
Issue
20
Pages
2375-2390
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2310716991
Cited by
7,831
References
158
Citations by year
2026: 312 · 2025: 498 · 2024: 703 · 2023: 859 · 2022: 959 · 2021: 1129 · 2020: 900 · 2019: 831 · 2018: 799 · 2017: 657 · 2016: 158 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
127.99
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
National Cancer Institute (P30CA008748)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
lymphoid malignancies, WHO classification of lymphoid neoplasms, lymphoma diagnosis, diagnostic criteria, targeted therapy, lymphoma classification
MeSH terms
Humans, Leukemia, Lymphoid, Lymphatic Diseases, Lymphocytes, Lymphoma, Paraproteinemias, World Health Organization, Oncogene Proteins, Fusion, Genes, Neoplasm

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