Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis
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Key Points: Angiocrine Bmp2 signaling in the liver controls tissue and serum iron concentrations via regulation of hepcidin expression in hepatocytes. Liver-specific angiocrine signaling is essential for the metabolic homeostasis of the whole organism.
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BMP2 is less iron sensitive and is highly expressed in basal conditions.
“BMP2 is less iron sensitive and is highly expressed in basal conditions.44,45”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [44]
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Cites
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In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
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A Red carpet for iron metabolism
Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017) · Cell · doi:10.1016/j.cell.2016.12.034 · Cited by 1,319 · see citing works
Iron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734 · see citing works
“BMP2 is less iron sensitive and is highly expressed in basal conditions.(44,45) Inflammatory cytokines such as interleukin (IL)-6 upregulate hepcidin expression by activating the IL-6RJAK2-STAT3 pathway.”
Liver iron sensing and body iron homeostasis
Wang, C.-Y., & Babitt, J. L. (2019) · Blood · doi:10.1182/blood-2018-06-815894 · Cited by 360 · see citing works
Iron and innate antimicrobial immunity-depriving the pathogen, defending the host
Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123 · see citing works
Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice
Leibing, T., Géraud, C., Augustin, I., Boutros, M., Augustin, H. G., Okun, J. G., Langhans, C., Zierow, J., Wohlfeil, S. A., Olsavszky, V., et al. (2018) · Hepatology · doi:10.1002/hep.29613 · Cited by 116 · see citing works
Self-citationIron metabolism under conditions of ineffective erythropoiesis in β-thalassemia
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Angiocrine signaling in sinusoidal homeostasis and liver diseases
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GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Zhao, D., Huang, Z., Li, X., Wang, H., Hou, Q., Wang, Y., Yan, F., Yang, W., Liu, D., Yi, S., et al. (2024) · eLife · doi:10.7554/elife.95811 · Cited by 17 · see citing works
- Authors
- Koch, P.-S., Olsavszky, V., Ulbrich, F., Sticht, C., Demory, A., Leibing, T., Henzler, T., Meyer, M., Zierow, J., Schneider, S., Breitkopf-Heinlein, K., Gaitantzi, H., Spencer-Dene, B., Arnold, B., Klapproth, K., Schledzewski, K., Goerdt, S., & Géraud, C.
- Affiliations
- Department of Dermatology, Venereology and Allergology, Center of Excellence in Dermatology,
- Center for Medical Research,
- Institute of Clinical Radiology and Nuclear Medicine,
- Institute for Clinical Chemistry, and
- Section of Molecular Hepatology, Second Medical Department, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;
- Heidelberg University (DE)
- Experimental Histopathology Laboratory, The Francis Crick Institute, London, United Kingdom; and
- Division of Molecular Immunology, and
- German Cancer Research Center (DE)
- Corresponding author
- Olsavszky, Victor
- Goerdt, Sergij
- Géraud, Cyrill
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-01-26
- Volume
- 129
- Issue
- 4
- Pages
- 415-419
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5291964
- OpenAlex
- W2559408993
- Cited by
- 161
- References
- 3
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 19 · 2023: 16 · 2022: 12 · 2021: 15 · 2020: 21 · 2019: 18 · 2018: 21 · 2017: 16
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute (10009)
- Deutsche Forschungsgemeinschaft (Project 7, DFG INST 91027/9-1 FUGG, GRK2099, RTG2099, Project B1, SFB‐TR23)
- Arbeitsgemeinschaft Dermatologische Forschung
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- angiocrine signaling, BMP-2, BMP6, iron homeostasis, hepcidin, liver iron overload, hereditary hemochromatosis, serum iron, iron accumulation
- MeSH terms
- Animals, Capillaries, Female, Gene Expression Regulation, Hemochromatosis, Homeostasis, Iron, Liver, Male, Mice, Transgenic, Transcription, Genetic, Signal Transduction, Cell Adhesion Molecules, Neuronal, Integrases, Paracrine Communication, Hepatocytes, Endothelial Cells, Mice, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 6, Hepcidins
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