Cited by 57Hematopoietic Stem Cell TransplantationHistone Deacetylase Inhibitors ResearchBlood disorders and treatments

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Open access
Hua, Wei-Kai, Qi, Jing, Cai, Qi, Carnahan, Emily, Ayala Ramirez, Maria, Li, Ling, Marcucci, Guido, Kuo, Ya-Huei·2017·Blood

Abstract

-deficient mice challenged with serial 5-fluorouracil treatment. This hypersensitivity to hematopoietic ablation was completely rescued by inactivation of p53. Altogether, these results indicate that HDAC8 functions to modulate p53 activity to ensure LT-HSC maintenance and cell survival under stress.

Integrity signals

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Crossref · 10.1182/blood-2017-03-771386

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58 of 58 references verified0 citation errors · 0 not checkable

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Authors
Hua, W.-K., Qi, J., Cai, Q., Carnahan, E., Ayala Ramirez, M., Li, L., Marcucci, G., & Kuo, Y.-H.
Affiliations
  • City Of Hope National Medical Center (US)
  • Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA
Venue
Blood
Published
2017-12-14
Volume
130
Issue
24
Pages
2619-2630
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2766590494
Cited by
57
References
58
Citations by year
2026: 6 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 12 · 2021: 4 · 2020: 10 · 2019: 8 · 2018: 2
FWCI
4.22
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01CA178387, P30CA033572)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
HDAC8, hematopoietic stem cells, p53, 5-fluorouracil, stress response, cell survival, histone deacetylase, p53 regulation
MeSH terms
Acetylation, Animals, Antimetabolites, Cell Differentiation, Cell Survival, Fluorouracil, Gene Expression Regulation, Hematopoietic Stem Cells, Histone Deacetylases, Mice, Inbred C57BL, Mice, Transgenic, Stress, Physiological, Time Factors, Tumor Suppressor Protein p53, Mice, Knockout

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