Immune insights into AA
Abstract
In this issue of Blood , Zaimoku et al demonstrate that the functional loss of the HLA-B4002 allele is common in aplastic anemia (AA) patients, suggesting that this allele plays a major role in the immune attack underlying the pathophysiology of this disease. 1
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Other mutations commonly found in clonal hematopoiesis can be selected due to overall BM hypocellularity.
“Other mutations commonly found in clonal hematopoiesis can simply be selected due to the overall BM hypocellularity.64”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [64]
Cites
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Yoshizato, T., Dumitriu, B., Hosokawa, K., Makishima, H., Yoshida, K., Townsley, D., Sato-Otsubo, A., Sato, Y., Liu, D., Suzuki, H., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414799 · Cited by 646 · see citing works
7 Paroxysmal nocturnal haemoglobinuria
Rotoli, B., & Luzzatto, L. (1989) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(89)80010-1 · Cited by 243 · see citing works
Risitano, A. M., Maciejewski, J. P., Green, S., Plasilova, M. L., Zeng, W., & Young, N. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16724-x · Cited by 242 · see citing works
Self-citationCurrent concepts in the pathophysiology and treatment of aplastic anemia
Young, N. S. (2013) · Hematology · doi:10.1182/asheducation-2013.1.76 · Cited by 199 · see citing works
Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia
Katagiri, T., Sato‐Otsubo, A., Kashiwase, K., Morishima, S., Sato, Y., Mori, Y., Kato, M., Sanada, M., Morishima, Y., Hosokawa, K. T., et al. (2011) · Blood · doi:10.1182/blood-2011-07-365189 · Cited by 182 · see citing works
Nakao, S., Takami, A., Takamatsu, H., Zeng, W., Sugimori, N., Yamazaki, H., Miura, Y., Ueda, M., Shiobara, S., Yoshioka, T., et al. (1997) · Blood · doi:10.1182/blood.v89.10.3691 · Cited by 112 · see citing works
Zaimoku, Y., Takamatsu, H., Hosomichi, K., et al. (2017) · Blood · doi:10.1182/blood-2016-11-752378 · Cited by 94 · see citing works
Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., et al. (2013) · Blood · doi:10.1182/blood-2012-11-469353 · Cited by 89 · see citing works
Gargiulo, L., Zaimoku, Y., Scappini, B., Maruyama, H., Ohumi, R., Luzzatto, L., Nakao, S., & Notaro, R. (2016) · Blood · doi:10.1182/blood-2016-09-740845 · Cited by 39 · see citing works
Malcovati, L., Gallì, A., Travaglino, E., et al. (2016) · Blood · doi:10.1182/blood.v128.22.298.298 · Cited by 2 · see citing works
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Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
- Authors
- Risitano, A. M.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Risitano, Antonio M.
- ORCID
- Risitano, Antonio M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-05-25
- Volume
- 129
- Issue
- 21
- Pages
- 2824-2826
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2620192899
- Cited by
- 3
- References
- 10
- Citations by year
- 2019: 1 · 2018: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- aplastic anemia, HLA loss, autoimmunity, disease pathophysiology
- MeSH terms
- Humans, Immunosuppressive Agents
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