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Cited by 197Multiple Myeloma Research and TreatmentsCancer Immunotherapy and BiomarkersMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Pembrolizumab, pomalidomide, and low-dose dexamethasone for relapsed/refractory multiple myeloma

Badros, Ashraf, Hyjek, Elizabeth, Ma, Ning, Lesokhin, Alexander, Dogan, Ahmet, Rapoport, Aaron P., Kocoglu, Mehmet, Lederer, Emily, Philip, Sunita, Milliron, Todd, Dell, Cameron, Goloubeva, Olga, Singh, Zeba·2017·Blood
DOI 10.1182/blood-2017-03-775122
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Abstract

Programmed death 1 (PD-1) receptor and its ligand (PD-L1) facilitate immune evasion in multiple myeloma (MM). We hypothesized that pembrolizumab, PD-1-antibody, can enhance antimyeloma cellular immunity generated by pomalidomide, leading to improved clinical responses. In this single-center, phase 2 study, 48 patients with relapsed/refractory MM (RRMM) received 28-day cycles of pembrolizumab, 200 mg IV every 2 weeks, pomalidomide 4 mg daily for 21 days, and dexamethasone 40 mg weekly. Patients had a median of 3 (range: 2-5) lines of therapy, median age 64 (range: 35-83) years, and had received both an immune modulatory drug (IMiD) and proteasome inhibitor: (35 [73%] of 48) were refractory to both; (31 [70%]) had received an autologous transplant, and (30 [62%]) had high-risk cytogenetics. Adverse events grade 3 to 4 occurred in (19 [40%] of 48 patients), including hematologic toxicities (19 [40%]), hyperglycemia (12 [25%]), and pneumonia (7 [15%]). Autoimmune events included pneumonitis (6 [13%]) and hypothyroidism (5 [10%]), mostly ≤ grade 2. Objective responses occurred in (29 [60%] of 48) patients, including stringent complete response/complete response (4 [8%]), very good partial response (9 [19%]), and partial response (16 [33%]); median duration of response was 14.7 months. At median follow-up of 15.6 months, progression-free survival (PFS) was 17.4 months and overall survival was not reached. Analyses of pretreatment marrow samples revealed a trend for increased expression of PD-L1 in responding patients and longer PFS with increased T-lymphocyte infiltrates, irrespective of PD-1 expression. Pembrolizumab, pomalidomide, and low-dose dexamethasone have acceptable safety and durable responses in RRMM patients. This trial was registered at www.clincialtrials.gov as #NCT02289222.

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Crossref · 10.1182/blood-2017-03-775122

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Metadata

Authors
Badros, A., Hyjek, E., Ma, N., Lesokhin, A., Dogan, A., Rapoport, A. P., Kocoglu, M., Lederer, E., Philip, S., Milliron, T., Dell, C., Goloubeva, O., & Singh, Z.
Affiliations
  • University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (US)
  • University of Chicago (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • Memorial Sloan Kettering Cancer Center, New York, NY
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2017-09-07
Volume
130
Issue
10
Pages
1189-1197
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2017-03-775122
OpenAlex
W2610269487
Cited by
197
References
38
Citations by year
2026: 4 · 2025: 8 · 2024: 10 · 2023: 10 · 2022: 12 · 2021: 24 · 2020: 31 · 2019: 34 · 2018: 46 · 2017: 16
FWCI
26.76
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords
pembrolizumab, pomalidomide, low-dose dexamethasone, relapsed/refractory multiple myeloma, PD-1 inhibitors, PD-L1 expression, immune evasion, combination immunotherapy, T cell infiltration, progression-free survival, adverse events, pneumonitis, hypothyroidism, hematologic toxicity, hyperglycemia
MeSH terms
Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Demography, Dexamethasone, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Multiple Myeloma, Pneumonia, Thalidomide, Biomarkers, Tumor, Treatment Outcome, Kaplan-Meier Estimate, Intention to Treat Analysis, Antibodies, Monoclonal, Humanized

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