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Chronic immune response dysregulation in MDS pathogenesis
Open accessAbstract
Chronic innate immune signaling in hematopoietic cells is widely described in myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly via pattern recognition receptors, increases the risk of developing MDS. An inflammatory component to MDS has been reported for many years, but only recently has evidence supported a more direct role of chronic innate immune signaling and associated inflammatory pathways in the pathogenesis of MDS. Here we review recent findings and discuss relevant questions related to chronic immune response dysregulation in MDS.
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“Human myelodysplastic syndrome (MDS) HSPCs have shown significant innate immune system dysregulation and resistance to the pro-proliferative effects of inflammation [69,80,81].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [80]
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“Dysregulated inflammatory signaling has emerged as a key partner alongside oncogenic mutations in the development and/or progression of hematological malignancy (Barreyro et al., 2018; Pietras, 2017).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Barreyro et al., 2018
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“Chronic inflammation, often associated with increased IL-1 activity, is a common phenotype in individuals at risk for hematological malignancy, which can be related to several preexisting factors, including aging/tissue decline, genotoxin exposure, metabolic dysfunction, and/or autoimmune disease (Barreyro et al., 2018; Pietras, 2017).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Barreyro et al., 2018
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Citations
Cites
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Dnmt3a is essential for hematopoietic stem cell differentiation
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Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling
Hormaechea-Agulla, D., Matatall, K. A., Le, D. T., Kain, B., Long, X., Kus, P., Jaksik, R., Challen, G. A., Kimmel, M., & King, K. Y. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.002 · Cited by 329
Inflammation-Induced Tumorigenesis and Metastasis
Hibino, S., Kawazoe, T., Kasahara, H., Itoh, S., Ishimoto, T., Sakata‐Yanagimoto, M., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115421 · Cited by 319
The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
Sallman, D. A., & List, A. (2019) · Blood · doi:10.1182/blood-2018-10-844654 · Cited by 273
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Self-citationInnate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS
Trowbridge, J. J., & Starczynowski, D. T. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201544 · Cited by 189
Self-citation
Metadata
- Authors
- Barreyro, L., Chlon, T. M., & Starczynowski, D. T.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Barreyro, Laura
- Chlon, Timothy M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-11
- Volume
- 132
- Issue
- 15
- Pages
- 1553-1560
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6182269
- OpenAlex
- W2885816375
- Cited by
- 226
- References
- 114
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 28 · 2023: 26 · 2022: 43 · 2021: 35 · 2020: 23 · 2019: 23 · 2018: 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Society of Hematology
- Leukemia and Lymphoma Society
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health (1f32hl143993-01, RO1DK102759)
- National Heart, Lung, and Blood Institute (R35HL135787, F32 HL143993)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK102759, RO1DK102759, R01DK113639)
- National Institute of Environmental Health Sciences (T32ES007250)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- myelodysplastic syndrome, innate immune signaling, pattern recognition receptors, inflammation, hematopoietic cells, MDS pathogenesis
- MeSH terms
- Animals, Hematopoietic Stem Cells, Humans, Immunity, Innate, Inflammation, Myelodysplastic Syndromes
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