Cited by 2,345Redox biology and oxidative stressAntioxidant Activity and Oxidative StressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

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WISEMAN, Helen, HALLIWELL, Barry·1996·Biochemical Journal

Abstract

Review Article| January 01 1996 Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Helen WISEMAN; Helen WISEMAN *Department of Nutrition and Dietetics, King's College London, Campden Hill Road, London W8 7AH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Barry HALLIWELL Barry HALLIWELL †Pharmacology Group, King's College London, Manresa Road, London SW3 6LX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1996) 313 (1): 17–29. https://doi.org/10.1042/bj3130017 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Helen WISEMAN, Barry HALLIWELL; Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 1 January 1996; 313 (1): 17–29. doi: https://doi.org/10.1042/bj3130017 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. The Biochemical Society, London © 19961996 Article PDF first page preview Close Modal You do not currently have access to this content.

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  • Endogenous free radicals generated during metabolism and exogenous factors such as UV or ionizing radiation interfere with genome integrity.

    “A number of endogenous factors such as free radicals [34] generated during metabolic processes as well as exogenous factors such as UV or ionizing radiations [35] are known to interfere with genome integrity.”
  • At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.

    “At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.2, 6, 7”

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Research works printed but not linked: 18

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  3. Epe, B (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 41-65, Ellis Horwood, Chichester 14
  4. Weitzman, S. A., Turk, P. W., Howard-Milkowski, D. and Kozlowski, K. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1261-1264
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  7. Cheeseman, K. (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 109-144, Ellis Horwood, Chichester 35
  8. Hagen, T. M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N. and Chisari, F. V. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 12808-12812
  9. Satoh, M. S., Jones, C. J., Wood, R. D. and Lindahl, T. (1993) Proc. Natl. Acad. Sci.
  10. Mo, J. Y., Maki, H. and Sekiguchi, M. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 11021-11025
  11. Zimmerman, R. and Cerutti, P. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 2085-2087
  12. Basu, A. K., Loechler, E. L., Leadon, S. A. and Essigmann, J. M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7677-7681 104
  13. Reid, T. M. and Loeb, L. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 3905-3907 112
  14. Brash, D., Rudolph, J., Simon, J., Lin, A., Mckenna, G., Baden, H., Halperin, A. and Ponten, J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10124-10128 114
  15. Church, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S. and Trent, J. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 3113-3117 127
  16. Gardener, D. L., Fitzmaurice, R. L. and Stachan, M. (1995) Ann. Rheum. Dis., in the press 137
  17. Leanderson, P. and Tageson, C. (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 293-314, Ellis Horwood, Chichester 159
  18. Fraga, C. G., Motchnik, P. A., Shigenaga, M. J. K., Helbock, H. J., Jacob, R. A. and Ames, B. N. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11003-11006 189

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Authors
WISEMAN, H., & HALLIWELL, B.
Affiliations
King's College London (GB)
Corresponding author
WISEMAN, Helen
Venue
Biochemical Journal
Published
1996-01-01
Volume
313
Issue
1
Pages
17-29
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W2164613158
Cited by
2,345
References
204
Citations by year
2026: 18 · 2025: 37 · 2024: 42 · 2023: 36 · 2022: 56 · 2021: 70 · 2020: 77 · 2019: 95 · 2018: 111 · 2017: 132 · 2016: 107 · 2015: 129 · 2014: 129 · 2013: 124 · 2012: 120
FWCI
4.58
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
DNA damage, reactive oxygen species, reactive nitrogen species, inflammatory diseases, tumor progression, oxidative stress, inflammation and carcinogenesis
MeSH terms
Animals, DNA, DNA Damage, Free Radicals, Humans, Inflammation, Neoplasms, Nitrogen Oxides, Reactive Oxygen Species, Disease Progression

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