Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer
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Review Article| January 01 1996 Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Helen WISEMAN; Helen WISEMAN *Department of Nutrition and Dietetics, King's College London, Campden Hill Road, London W8 7AH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Barry HALLIWELL Barry HALLIWELL †Pharmacology Group, King's College London, Manresa Road, London SW3 6LX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1996) 313 (1): 17–29. https://doi.org/10.1042/bj3130017 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Helen WISEMAN, Barry HALLIWELL; Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 1 January 1996; 313 (1): 17–29. doi: https://doi.org/10.1042/bj3130017 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. The Biochemical Society, London © 19961996 Article PDF first page preview Close Modal You do not currently have access to this content.
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Endogenous free radicals generated during metabolism and exogenous factors such as UV or ionizing radiation interfere with genome integrity.
“A number of endogenous factors such as free radicals [34] generated during metabolic processes as well as exogenous factors such as UV or ionizing radiations [35] are known to interfere with genome integrity.”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [34]
At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.
“At low to moderate levels, ROS act as signaling transducers to activate cancer cell proliferation, migration, invasion, angiogenesis, and drug resistance.2, 6, 7”
From Reactive Oxygen Species in Cancer: Current Findings and Future Directions (2021) · cites this paper as [6]
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Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,420 · see citing works
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321 · see citing works
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121 · see citing works
Oxidative damage and mitochondrial decay in aging.
Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055 · see citing works
A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959 · see citing works
The Chemical Basis of Radiation Biology
O'Neill, P. (1987) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008714552571 · Cited by 1,844 · see citing works
The chemical basis of radiation biology
von Sonntag, C. (1987) · Medical Entomology and Zoology · Cited by 1,748 · see citing works
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B. B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,526 · see citing works
Self-citationREPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology
Demple, B., & Harrison, L. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.004411 · Cited by 1,495 · see citing works
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
Paillerets, B. B., Kew, M. C., Wands, J. R., & Öztürk, M. (1991) · Nature · doi:10.1038/350429a0 · Cited by 1,433 · see citing works
Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,411 · see citing works
Stadtman, E. R. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.004053 · Cited by 1,408 · see citing works
The antioxidants of human extracellular fluids
Halliwell, B. B., & Gutteridge, J. M. C. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90510-6 · Cited by 1,340 · see citing works
Self-citationSuperoxide and hydrogen peroxide in relation to mammalian cell proliferation
Burdon, R. H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00198-s · Cited by 1,166 · see citing works
Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea
Pryor, W. A., & Stone, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,154 · see citing works
Strand, M. K., Prolla, T. A., Liskay, R. M., & Petes, T. D. (1993) · Nature · doi:10.1038/365274a0 · Cited by 1,077 · see citing works
Free Radicals and Antioxidants: A Personal View
Halliwell, B. B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1994.tb01453.x · Cited by 1,075 · see citing works
Self-citationOhshima, H., & Bartsch, H. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90245-3 · Cited by 1,050 · see citing works
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works
Diet and Health: What Should We Eat?
Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008 · see citing works
Role of superoxide dismutase in cancer: a review.
Oberley, L. W., & Buettner, G. R. (1979) · PubMed · Cited by 982 · see citing works
[23] Oxidative chemistry of peroxynitrite
Beckman, J. S., Chen, J., Ischiropoulos, H., & Crow, J. P. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33026-3 · Cited by 973 · see citing works
How to Characterize a Biological Antioxidant
Halliwell, B. B. (1990) · Free Radical Research Communications · doi:10.3109/10715769009148569 · Cited by 931 · see citing works
Self-citationHarman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902 · see citing works
Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
Collins, A. R., Duthie, S. J., & Dobson, V. L. (1993) · Carcinogenesis · doi:10.1093/carcin/14.9.1733 · Cited by 830 · see citing works
Antioxidant Functions of Vitamins
Sies, H., Stahl, W., & Sundquist, A. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb17085.x · Cited by 827 · see citing works
Cytotoxicity and genotoxicity of lipid-oxidation products
Esterbauer, H. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.5.779s · Cited by 817 · see citing works
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Fraga, C., Motchnik, P., Shigenaga, M., Helbock, H., Jacob, R., & Ames, B. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.24.11003 · Cited by 809 · see citing works
Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
Weitzman, S., & Gordon, L. I. (1990) · Blood · doi:10.1182/blood.v76.4.655.655 · Cited by 761 · see citing works
Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma
Ross, R. K., Yu, M. C., Henderson, B. E., Yuan, J., Qian, G.-S., Tu, J.-T., Gao, Y.-T., Wogan, G. N., & Groopman, J. D. (1992) · The Lancet · doi:10.1016/0140-6736(92)91528-g · Cited by 725 · see citing works
Endogenous Oxidative DNA Damage, Aging, and Cancer
Ames, B. N. (1989) · Free Radical Research Communications · doi:10.3109/10715768909087933 · Cited by 708 · see citing works
Kaur, H., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706 · see citing works
Self-citationHydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation
Floyd, R. A., Watson, J. J., Wong, P. K., Altmiller, D. H., & Rickard, R. C. (1986) · Free Radical Research Communications · doi:10.3109/10715768609083148 · Cited by 663 · see citing works
Loft, S., Vistisen, K., Ewertz, M., Tjønneland, A., Overvad, K., & Poulsen, H. E. (1992) · Carcinogenesis · doi:10.1093/carcin/13.12.2241 · Cited by 643 · see citing works
Gutteridge, J. M. C. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80626-3 · Cited by 629 · see citing works
Programmed cell death and Bcl-2 protection in very low oxygen
Jacobson, M. D., & RAFF, M. C. (1995) · Nature · doi:10.1038/374814a0 · Cited by 625 · see citing works
Body Iron Stores and the Risk of Cancer
Stevens, R. G., Jones, D. Y., Micozzi, M. S., & Taylor, P. R. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810203191603 · Cited by 576 · see citing works
Cerutti, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92832-0 · Cited by 566 · see citing works
Dietary Carotenes, Vitamin C, and Vitamin E as Protective Antioxidants in Human Cancers
Byers, T., & Perry, G. (1992) · Annual Review of Nutrition · doi:10.1146/annurev.nu.12.070192.001035 · Cited by 526 · see citing works
Oxidants and free radicals in inflammatory bowel disease
Grisham, M. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92831-2 · Cited by 525 · see citing works
Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P. L., Condorelli, M., & Chiariello, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46660-9 · Cited by 515 · see citing works
Church, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S., & Trent, J. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.3113 · Cited by 474 · see citing works
Reactive oxygen species in tumorigenesis.
Feig, D. I., Reid, T. M., & Loeb, L. A. (1994) · PubMed · Cited by 472 · see citing works
Down-regulation of bcl-2 by p53 in breast cancer cells.
Haldar, S., Negrini, M., Monne, M. I., Sabbioni, S., & Croce, C. M. (1994) · PubMed · Cited by 471 · see citing works
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
Boughton-Smith, N. K., Evans, S., Whittle, B. J. R., Moncada, S., Hawkey, C. J., COLE, A. T., & Balsitis, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91476-3 · Cited by 459 · see citing works
Sakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., KAWABATA, S., Maki, H., & Sekiguchi, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49494-5 · Cited by 435 · see citing works
β-Carotene and α-tocopherol are synergistic antioxidants
Palozza, P., & Krinsky, N. I. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90658-j · Cited by 412 · see citing works
Carcinogen-mediated oxidant formation and oxidative DNA damage
Frenkel, K. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90047-4 · Cited by 379 · see citing works
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
Corral‐Debrinski, M., Shoffner, J. M., Lott, M. T., & Wallace, D. C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90021-g · Cited by 360 · see citing works
Antioxidants and disease prevention
Diplock, A. T. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90005-1 · Cited by 358 · see citing works
Halliwell, B. B. (1991) · Drugs · doi:10.2165/00003495-199142040-00003 · Cited by 354 · see citing works
Self-citationChemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease
Simmonds, N. J., Allen, R. E., Stevens, T., NIALL, R., Someren, M. V., Blake, D. R., & Rampton, D. S. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91112-h · Cited by 353 · see citing works
The data support a role for antioxidants in reducing cancer risk.
Block, G. (2009) · Nutrition reviews · doi:10.1111/j.1753-4887.1992.tb01329.x · Cited by 351 · see citing works
Inflammatory breast cancer: a review.
Jaiyesimi, I. A., Buzdar, A. U., & Hortobágyi, G. N. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.6.1014 · Cited by 342 · see citing works
Hatahet, Z., Kow, Y. W., Purmal, A. A., Cunningham, R. P., & Wallace, S. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32239-1 · Cited by 337 · see citing works
The Reaction of Nitric Oxide with Organic Peroxyl Radicals
Padmaja, S., & Huie, R. E. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2079 · Cited by 323 · see citing works
Mo, J. Y., Maki, H., & Sekiguchi, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11021 · Cited by 312 · see citing works
Antioxidants in Nutrition, Health, and Disease
Gutteridge, J. M. C., & Halliwell, B. B. (1995) · doi:10.1093/oso/9780198549024.001.0001 · Cited by 310 · see citing works
Self-citationHagen, T. M., Huang, S., Curnutte, J. T., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N., & Chisari, F. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12808 · Cited by 310 · see citing works
A Prospective Study of the Intake of Vitamins C, E, and A and the Risk of Breast Cancer
Hunter, D. J., Manson, J. E., Colditz, G. A., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., Speizer, F. E., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307223290403 · Cited by 307 · see citing works
Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro
Yermilov, V., Rubio, J., Becchi, M., Friesen, M. D., Pignatelli, B., & Ohshima, H. (1995) · Carcinogenesis · doi:10.1093/carcin/16.9.2045 · Cited by 301 · see citing works
Free radical adducts induce alterations in DNAcytosine methylation.
Weitzman, S. A., Turk, P. W., Milkowski, D. H., & Kozlowski, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1261 · Cited by 299 · see citing works
Spontaneous cancer and its possible relationship to oxygen metabolism.
Totter, J. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.1763 · Cited by 297 · see citing works
van der Vliet, A., Smith, D. R., O’Neill, C., Kaur, H., Darley-Usmar, V. M., Cross, C. E., & Halliwell, B. B. (1994) · Biochemical Journal · doi:10.1042/bj3030295 · Cited by 286 · see citing works
Self-citationDNA base modifications in chromatin of human cancerous tissues
Oliński, R., Zastawny, T. H., Budzbon, J., Skokowski, J., Zegarski, W., & Dizdaroğlu, M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81093-2 · Cited by 284 · see citing works
Aruoma, O. I., Halliwell, B. B., & DPhil, B. H. (1993) · Medical Entomology and Zoology · Cited by 283 · see citing works
Self-citationDizdaroğlu, M., Laval, J., & Boiteux, S. (1993) · Biochemistry · doi:10.1021/bi00096a022 · Cited by 283 · see citing works
Endogenous DNA adducts: Potential and paradox
Marnett, L. J., & Burcham, P. C. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00036a005 · Cited by 281 · see citing works
Shimoda, R., Nagashima, M., Sakamoto, M., Yamaguchi, N., Hirohashi, S., Yokota, J., & Kasai, H. (1994) · PubMed · Cited by 279 · see citing works
Spencer, J. P. E., Jenner, A. M., Aruoma, O. I., Evans, P., Kaur, H., Dexter, D. T., Jenner, P. G., Lees, A. J., Marsden, D. C., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01056-0 · Cited by 278 · see citing works
Self-citationMajor alterations in the nucleotide structure of DNA in cancer of the female breast.
Malins, D. C., & Haimanot, R. (1991) · PubMed · Cited by 267 · see citing works
Heller, B., Wang, Z., Wagner, E. F., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11176 · Cited by 266 · see citing works
Peroxynitrite-induced rat colitis—A new model of colonic inflammation
Rachmilewitz, D., Stamler, J. S., Karmeli, F., Mullins, M. E., Singel, D. J., Loscalzo, J., Xavier, R. J., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91063-n · Cited by 262 · see citing works
Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA
deRojas-Walker, T., Tamir, S., Ji, H., Wishnok, J. S., & Tannenbaum, S. R. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00045a020 · Cited by 253 · see citing works
Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.
Bashir, S., Harris, G., Denman, M., Blake, D. R., & Winyard, P. G. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.9.659 · Cited by 250 · see citing works
Dizdaroglu, M., Rao, G., Halliwell, B. B., & Gajewski, E. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90366-q · Cited by 244 · see citing works
Self-citationMa, S., Ss, P., Coleman, C. N., & Calderwood, S. K. (1994) · PubMed · Cited by 244 · see citing works
Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques
Halliwell, B. B., & Dizdaroglu, M. (1992) · Free Radical Research Communications · doi:10.3109/10715769209049161 · Cited by 243 · see citing works
Self-citationOxidative DNA base damage and antioxidant enzyme activities in human lung cancer
Jaruga, P., Zastawny, T. H., Skokowski, J., Dizdaroğlu, M., & Oliński, R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80240-8 · Cited by 242 · see citing works
Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents
Marletta, M. A. (1988) · Chemical Research in Toxicology · doi:10.1021/tx00005a001 · Cited by 241 · see citing works
Reactive oxygen and DNA damage in mitochondria
Richter, C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90029-o · Cited by 240 · see citing works
Activated neutrophils induce prolonged DNA damage in neighboring cells
Shacter, E. B., Beecham, E. J., Covey, J. M., et al. (1988) · Carcinogenesis · doi:10.1093/carcin/9.12.2297 · Cited by 238 · see citing works
Clinical Evidence Supporting the Radical Scavenger Mechanism of 5-Aminosalicylic Acid
Ahnfelt-Rønne, I., Nielsen, O. H., Christensen, A., Langholz, E., Binder, V., & Riis, P. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90329-y · Cited by 235 · see citing works
Hopman, A. H. N., Moesker, O., SMEETS, A. W. G. B., et al. (1991) · PubMed · Cited by 231 · see citing works
Inflammation, chromosomal instability, and cancer: the schistosomiasis model.
Rosin, M. P., Anwar, W. A. R., & Ward, A. J. (1994) · PubMed · Cited by 228 · see citing works
Kunkel, T. A. (1993) · Nature · doi:10.1038/365207a0 · Cited by 222 · see citing works
Wei, H., & Frenkel, K. (1993) · Carcinogenesis · doi:10.1093/carcin/14.6.1195 · Cited by 216 · see citing works
Deleterious mitochondrial DNA mutations accumulate in aging human tissues
Arnheim, N., & Cortopassi, G. A. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90020-p · Cited by 215 · see citing works
Candeias, L. P., Patel, K. B., Stratford, M. R. L., & Wardman, P. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80394-a · Cited by 212 · see citing works
Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.
Zimmerman, R., & Cerutti, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.2085 · Cited by 208 · see citing works
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Basu, A. K., Loechler, E. L., Leadon, S. A., & Essigmann, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7677 · Cited by 202 · see citing works
Invited Commentary is Apoptosis Mediated by Reactive Oxygen Species?
Sarafian, T. A., & Bredesen, D. E. (1994) · Free Radical Research · doi:10.3109/10715769409056549 · Cited by 198 · see citing works
The Relation of Infection With the Hepatitis B Agent to Primary Hepatic Carcinoma
Blumberg, B. S., Larouzé, B., London, W. T., Werner, B. G., Hesser, J. E., Millman, I., Saimot, G., & Payet, M. (2000) · World Scientific series in 20th century biology · doi:10.1142/9789812813688_0029 · Cited by 194 · see citing works
DNA oxidative damage and life expectancy in houseflies.
Agarwal, S., & Sohal, R. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12332 · Cited by 190 · see citing works
NAD(+)-dependent repair of damaged DNA by human cell extracts.
Satoh, M. S., Poirier, G. G., & Lindahl, T. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53346-9 · Cited by 188 · see citing works
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis
Slater, A. F. G., Nobel, S., Maellaro, E., Bustamante, J., Kimland, M., & Orrenius, S. (1995) · Biochemical Journal · doi:10.1042/bj3060771 · Cited by 188 · see citing works
Oxygen radicals, nitric oxide and human inflammatory joint disease.
Halliwell, B. B. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.6.505 · Cited by 182 · see citing works
Self-citationHarman, D. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9116-5_11 · Cited by 182 · see citing works
Satoh, M. S., Jones, C. J., Wood, R. D., & Lindahl, T. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6335 · Cited by 181 · see citing works
Oxidative DNA damage correlates with oxygen consumption in humans
Loft, S. H., Astrup, A. V., Buemann, B., & Poulsen, H. E. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.8.8181672 · Cited by 180 · see citing works
Kiyosawa, H., Suko, M., Okudaira, H., Murata, K., Miyamoto, E., Chung, M., Kasai, H., & Nishimura, S. (1990) · Free Radical Research Communications · doi:10.3109/10715769009109664 · Cited by 179 · see citing works
Suppression of colonic cancer by dietary phytic acid
Graf, E., & Eaton, J. W. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514232 · Cited by 177 · see citing works
Inflammatory bowel disease--a radical view.
Simmonds, N. J., & Rampton, D. S. (1993) · Gut · doi:10.1136/gut.34.7.865 · Cited by 175 · see citing works
Body Iron Stores and Risk of Colonic Neoplasia
Nelson, R. L., Davis, F. G., Sutter, E., Sobin, L. H., Kikendall, J. W., & Bowen, P. E. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.6.455 · Cited by 174 · see citing works
Li, Y., & Trush, M. A. (1994) · PubMed · Cited by 169 · see citing works
Role of reactive oxygen in bile salt stimulation of colonic epithelial proliferation.
Craven, P. A., Pfanstiel, J. F., & DeRubertis, F. R. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112382 · Cited by 163 · see citing works
Purmal, A. A., Kow, Y. W., & Wallace, S. S. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.1.72 · Cited by 161 · see citing works
Dizdaroglu, M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81120-o · Cited by 152 · see citing works
Li, Y., Trush, M. A., & Yager, J. D. (1994) · Carcinogenesis · doi:10.1093/carcin/15.7.1421 · Cited by 151 · see citing works
Guidot, D. M., McCord, J. M., Wright, R. M., & Repine, J. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74369-5 · Cited by 149 · see citing works
The scavenging of oxidants by sulphasalazine and its metabolites
Aruoma, O. I., Wasil, M., Halliwell, B. B., Hoey, B. M., & Butler, J. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90028-1 · Cited by 149 · see citing works
Self-citationClair, D. K. S., Wan, X. S., Oberley, T. D., Muse, K. E., & Clair, W. H. S. (1992) · Molecular Carcinogenesis · doi:10.1002/mc.2940060404 · Cited by 145 · see citing works
Redox Regulation of Programmed Cell Death in Lymphocytes
Buttke, T. M., & Sandstrom, P. A. (1995) · Free Radical Research · doi:10.3109/10715769509147548 · Cited by 145 · see citing works
Lunec, J., Herbert, K. E., Blount, S., Griffiths, H. R., & Emery, P. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00583-4 · Cited by 142 · see citing works
Tandem double CC-->TT mutations are produced by reactive oxygen species.
Reid, T. M., & Loeb, L. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.3904 · Cited by 142 · see citing works
Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase.
Safford, S. E., Oberley, T. D., Urano, M., & Clair, D. K. S. (1994) · PubMed · Cited by 138 · see citing works
Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis
Swain, J. A., Darley-Usmar, V. M., & Gutteridge, J. M. C. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80582-2 · Cited by 138 · see citing works
DNA damage and cancer: Measurement and mechanism
Wiseman, H., Kaur, H., & Halliwell, B. B. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03792-u · Cited by 133 · see citing works
Self-citationLicht, W. R., Tannenbaum, S. R., & Deen, W. M. (1988) · Carcinogenesis · doi:10.1093/carcin/9.3.365 · Cited by 129 · see citing works
Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene.
Hussain, S. P., Aguilar, F., Amstad, P., et al. (1994) · PubMed · Cited by 122 · see citing works
Gn, R., Lassegue, B. P., Griendling, K. K., & Rw, A. (1993) · PubMed · Cited by 122 · see citing works
Flint, D. H., Smyk-Randall, E. M., Tuminello, J. F., Draczynska‐Lusiak, B., & Brown, O. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74426-3 · Cited by 117 · see citing works
Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays
Claycamp, H. G. (1992) · Carcinogenesis · doi:10.1093/carcin/13.7.1289 · Cited by 113 · see citing works
On the limited ability of superoxide to release iron from ferritin
Bolann, B. J., & Ulvik, R. J. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19415.x · Cited by 111 · see citing works
Evans, J. N., Maccabee, M., Hatahet, Z., Courcelle, J., Bockrath, R. C., Ide, H., & Wallace, S. S. (1993) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(93)90092-r · Cited by 107 · see citing works
DNA Base Damage in Chromatin of γ-Irradiated Cultured Human Cells
Nackerdien, Z. E., Oliński, R., & Dizdaroğlu, M. (1992) · Free Radical Research Communications · doi:10.3109/10715769209049179 · Cited by 104 · see citing works
Geierstanger, B. H., Kagawa, T. F., Chen, S. L., et al. (1991) · Worldwide Protein Data Bank · doi:10.2210/pdb1d40/pdb · Cited by 101 · see citing works
Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.
Merry, P., Winyard, P. G., Morris, C. J., Grootveld, M. C., & Blake, D. R. (1989) · Annals of the Rheumatic Diseases · doi:10.1136/ard.48.10.864 · Cited by 100 · see citing works
Recognition of oxidized abasic sites by repair endonucleases
Häring, M., Rüdiger, H., Demple, B., et al. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.11.2010 · Cited by 99 · see citing works
Rosin, M. P. (1992) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(92)90071-9 · Cited by 98 · see citing works
Quantitative Determination of 8-Hydroxyguanine and Guanine by Isotope Dilution Mass Spectrometry
Hámberg, M., & Zhang, L. Y. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1422 · Cited by 98 · see citing works
Wei, H., & Frenkel, K. (1992) · PubMed · Cited by 96 · see citing works
Benamira, M., Johnson, K., Chaudhary, A. K., Bruner, K., Tibbetts, C., & Marnett, L. J. (1995) · Carcinogenesis · doi:10.1093/carcin/16.1.93 · Cited by 94 · see citing works
Dizdaroglu, M., Oliński, R., Doroshow, J. H., et al. (1993) · PubMed · Cited by 93 · see citing works
The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger
Ahnfelt-Rønne, I., & Nielsen, O. H. (1987) · Inflammation Research · doi:10.1007/bf01974941 · Cited by 92 · see citing works
Suppression of hydroperoxide-induced cytotoxicity by polyphenols.
Nakayama, T. (1994) · PubMed · Cited by 91 · see citing works
Neutrophil-mediated nitrosamine formation: Role of nitric oxide in rats
Grisham, M. B., Ware, K., Gilleland, H. E., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91513-4 · Cited by 89 · see citing works
DNA Sequence Changes Induced by Two Nitric Oxide Donor Drugs in the supF Assay
Routledge, M. N., Wink, D. A., Keefer, L. K., & Dipple, A. (1994) · Chemical Research in Toxicology · doi:10.1021/tx00041a007 · Cited by 85 · see citing works
Improvements in the analytical method for 8-hydroxydeoxyguanosine in nuclear DNA
Adachi, S., Zeisig, M., & Möller, L. (1995) · Carcinogenesis · doi:10.1093/carcin/16.2.253 · Cited by 85 · see citing works
Stillwell, W. G., Xu, H. X., Adkins, J. A., Wishnok, J. S., & Tannenbaum, S. R. (1989) · Chemical Research in Toxicology · doi:10.1021/tx00008a004 · Cited by 83 · see citing works
Wiseman, H., Paganga, G., Rice-Evans, C. A., et al. (1993) · Biochemical Journal · doi:10.1042/bj2920635 · Cited by 79 · see citing works
Self-citationKasprzak, K. S., Diwan, B. A., Rice, J. M., et al. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a013 · Cited by 79 · see citing works
Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line.
Yamashina, K., Miller, B. E., & Heppner, G. H. (1986) · PubMed · Cited by 78 · see citing works
Enzymatic repair of oxidative DNA damage.
Satoh, M. S., & Lindahl, T. L. (1994) · PubMed · Cited by 75 · see citing works
DNA base modifications and antioxidant enzyme activities in human benign prostatic hyperplasia
Oliński, R., Zastawny, T. H., Foksiński, M., Barecki, A., & Dizdaroğlu, M. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00171-f · Cited by 75 · see citing works
Formation of 8-Hydroxy-2′-deoxyguanosine in Epidermis of Hairless Mice Exposed to Near-UV
Hattori‐Nakakuki, Y., Nishigori, C., Okamoto, K., Imamura, S., Hiai, H., & Toyokuni, S. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1823 · Cited by 74 · see citing works
Eiserich, J. P., Vossen, V., O’neill, C. A., Halliwell, B. B., Cross, C. E., & van der Vliet, A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01011-0 · Cited by 71 · see citing works
Self-citationAnalysis of Uracil in DNA by Gas Chromatography-Mass Spectrometry
Blount, B., & Ames, B. N. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1257 · Cited by 70 · see citing works
Quantitative immunoanalysis of promutagenic 8-hydroxy-2'-deoxyguanosine in oxidized DNA
Musarrat, J., & Wani, A. A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.9.2037 · Cited by 69 · see citing works
Mutagenesis by metal-induced oxygen radicals.
Reid, T. M., Feig, D. I., & Loeb, L. A. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s357 · Cited by 67 · see citing works
Free Radical-Induced Double Base Lesions
Box, H. C., Freund, H. G., Budzinski, E. E., Wallace, J. C., & Maccubbin, A. E. (1995) · Radiation Research · doi:10.2307/3579095 · Cited by 67 · see citing works
Lipid peroxidation and mtDNA degeneration. A hypothesis
Hruszkewycz, A. M. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90028-n · Cited by 66 · see citing works
Carmichael, P. L., Shé, M. N., & Phillips, D. H. (1992) · Carcinogenesis · doi:10.1093/carcin/13.7.1127 · Cited by 65 · see citing works
Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine
Kamiya, H., Ueda, T., Matsukage, A., & Kasai, H. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.5.761 · Cited by 64 · see citing works
Takeuchi, T., & Morimoto, K. (1994) · Carcinogenesis · doi:10.1093/carcin/15.4.635 · Cited by 61 · see citing works
Singlet Oxygen induced mutation spectrum in mammalian cells
de Biologia, R. C., Riberio, D. T., Nigro, R. G., et al. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.16.4319 · Cited by 61 · see citing works
Nickel induces a signature mutation for oxygen free radical damage.
Tkeshelashvili, L. K., Reid, T. M., McBride, T. J., et al. (1993) · PubMed · Cited by 61 · see citing works
Tamoxifen; molecular basis of use in cancer; treatment and prevention
(1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(96)83107-7 · Cited by 61 · see citing works
Berger, S. J., Gosky, D. M., Zborowska, E., et al. (1994) · PubMed · Cited by 60 · see citing works
Mechanisms of mutation by oxidative DNA damage: Reduced fidelity of mammalian DNA polymerase .beta.
Feig, D. I., & Loeb, L. A. (1993) · Biochemistry · doi:10.1021/bi00067a040 · Cited by 58 · see citing works
Wilson, V. L., Taffe, B. G., Shields, P. G., et al. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.9399261 · Cited by 58 · see citing works
Chaudhary, A. K., Nokubo, M., Marnett, L. J., et al. (1994) · Journal of Mass Spectrometry · doi:10.1002/bms.1200230802 · Cited by 57 · see citing works
Dong, H. Y., Buard, A., Renier, A., Levy, F., Saint-Etienne, L., & Jaurand, M. (1994) · Carcinogenesis · doi:10.1093/carcin/15.6.1251 · Cited by 57 · see citing works
Pyrimidine Ring Fragmentation Products
Maccabee, M., Evans, J. S., Glackin, M. P., Hatahet, Z., & Wallace, S. S. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1162 · Cited by 55 · see citing works
Ancient DNA: Using molecular biology to explore the past
Brown, T. A., & Brown, K. A. (1994) · BioEssays · doi:10.1002/bies.950161006 · Cited by 55 · see citing works
Smith, A. G., Francis, J. E., & Carthew, P. (1990) · Carcinogenesis · doi:10.1093/carcin/11.3.437 · Cited by 55 · see citing works
Monochloramine, a neutrophil-derived oxidant, stimulates rat colonic secretion.
Tamai, H., Kachur, J. F., Baron, D. A., et al. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24803-0 · Cited by 54 · see citing works
Potential molecular mechanisms of oxidant-induced carcinogenesis.
Jackson, J. H. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s10155 · Cited by 52 · see citing works
Leaf, C. D., Wishnok, J. S., & Tannenbaum, S. R. (1991) · Carcinogenesis · doi:10.1093/carcin/12.3.537 · Cited by 48 · see citing works
Slater, T. F., Cheeseman, K. H., Benedetto, C., Collins, M., Emery, S., Maddix, S. P., Nodes, J. T., Proudfoot, K. A., Burton, G. W., & Ingold, K. U. (1990) · Biochemical Journal · doi:10.1042/bj2650051 · Cited by 47 · see citing works
Analysis of Cancer Incidence Data on the Basis of Multistage and Clonal Growth Models
Stein, W. D. (1991) · Advances in cancer research · doi:10.1016/s0065-230x(08)60481-9 · Cited by 45 · see citing works
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer
Jaruga, P., Zastawnya, T. H., Skokowski, J., et al. (1994) · Lung Cancer · doi:10.1016/0169-5002(94)92220-9 · Cited by 45 · see citing works
Tamoxifen — Molecular basis of use in cancer treatment and prevention
Briand, P. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)90110-8 · Cited by 44 · see citing works
Micronutrients and Their Influence on Mutagenicity and Malignant Transformationa
Krinsky, N. I. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39180.x · Cited by 43 · see citing works
7, 8-Dihydro-8-oxo-2′-deoxyguanosine present in DNA is not simply an artefact of isolation
Harris, G., Bashir, S., & Winyard, P. G. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.411 · Cited by 42 · see citing works
Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils.
Lim, J. S., Frenkel, K., & Troll, W. (1992) · PubMed · Cited by 42 · see citing works
Nicotera, T. M., Privalle, C. T., Wang, T., et al. (1994) · PubMed · Cited by 35 · see citing works
Effect of 5-aminosalicylic acid on ferrous sulfate-mediated damage to deoxyribose
Grisham, M. B. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90630-4 · Cited by 30 · see citing works
Effect of combinations of antioxidants on phagocyte-induced sister-chromatid exchanges
Weitberg, A. B. (1989) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(89)90002-5 · Cited by 29 · see citing works
Madzakf, C., & Sarasin, A. R. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90252-2 · Cited by 28 · see citing works
Marx, J. L. (1994) · Science · doi:10.1126/science.7973626 · Cited by 27 · see citing works
Goldring, C. E., Rice-Evans, C. A., Burdon, R. H., et al. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1305 · Cited by 26 · see citing works
Turk, P. W., & Weitzman, S. A. (1995) · Free Radical Research · doi:10.3109/10715769509064038 · Cited by 26 · see citing works
Effect of vitamin C supplementation on gastric mucosal DNA damage
Dyke, G. W., Craven, J. L., Hall, R., et al. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.291 · Cited by 26 · see citing works
Trush, M. A., Twerdok, L. E., & ESTERLINE, R. L. (1990) · Xenobiotica · doi:10.3109/00498259009046908 · Cited by 26 · see citing works
Markowitz, M. M., Rozen, P., Pero, R. W., et al. (1988) · Gut · doi:10.1136/gut.29.12.1680 · Cited by 26 · see citing works
Occupational exposures to Cd, Ni, and Cr modulate titers of antioxidized DNA base autoantibodies.
Frenkel, K., Karkoszka, J., Cohen, B. S., et al. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s3221 · Cited by 25 · see citing works
Inhibition of Chemically Induced Neoplastic Transformation by Carotenoids Mechanistic Studiesa
Bertram, J. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39170.x · Cited by 25 · see citing works
The formation of one-G deletions as a consequence of singlet-oxygen-induced DNA dmage
van den Akker, E., Lutgerink, J. T., Lafleur, M. V. M., Joenje, H., & Retèl, J. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90041-8 · Cited by 23 · see citing works
Ribeiro, D. T., de Oliveira, R. C., Mascio, P. D., et al. (1994) · Free Radical Research · doi:10.3109/10715769409056559 · Cited by 21 · see citing works
Modulation of oxidant formation in mouse skin in vivo by tumor-promoting phorbol esters.
Marnett, L. J., & Ji, C. (1994) · PubMed · Cited by 20 · see citing works
Increased susceptibility to oxidative DNA damage in regenerating liver
Adachi, S., Kawamura, K., & Takemoto, K. (1994) · Carcinogenesis · doi:10.1093/carcin/15.3.539 · Cited by 19 · see citing works
Ward, A. J., Olive, P. L., Burr, A., et al. (1993) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(93)90012-6 · Cited by 19 · see citing works
Nascimento, A. L. T. O., & Meneghini, R. (1995) · Carcinogenesis · doi:10.1093/carcin/16.6.1335 · Cited by 17 · see citing works
Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11
Parshad, R., Price, F. M., Oshimura, M., et al. (1992) · Human Genetics · doi:10.1007/bf00219338 · Cited by 16 · see citing works
Pathological and therapeutic implications for nitric oxide in inflammatory bowel disease.
Boughton-Smith, N. K. (1994) · PubMed · doi:10.1177/014107689408700602 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 18
- Totter, J. R. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 1763-1767
- Feig, D. I., Reid, T. M. and Loeb, L. A. (1994) Cancer Res. (Suppl.) 54, 1890s-1894s 6 Routledge, M. N., Wink, D. A., Keefer, L. K. and Dipple, A. (1994) Chem. Res. Toxicol. 7, 628-632
- Epe, B (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 41-65, Ellis Horwood, Chichester 14
- Weitzman, S. A., Turk, P. W., Howard-Milkowski, D. and Kozlowski, K. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 1261-1264
- Shigenaga, M. K., Hagen, T. M. and Ames, B. N. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 10771-10778
- Agarwal, S. and Sohal, R. S. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 12332-12335
- Cheeseman, K. (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 109-144, Ellis Horwood, Chichester 35
- Hagen, T. M., Huang, S., Curnutte, J., Fowler, P., Martinez, V., Wehr, C. M., Ames, B. N. and Chisari, F. V. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 12808-12812
- Satoh, M. S., Jones, C. J., Wood, R. D. and Lindahl, T. (1993) Proc. Natl. Acad. Sci.
- Mo, J. Y., Maki, H. and Sekiguchi, M. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 11021-11025
- Zimmerman, R. and Cerutti, P. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 2085-2087
- Basu, A. K., Loechler, E. L., Leadon, S. A. and Essigmann, J. M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7677-7681 104
- Reid, T. M. and Loeb, L. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 3905-3907 112
- Brash, D., Rudolph, J., Simon, J., Lin, A., Mckenna, G., Baden, H., Halperin, A. and Ponten, J. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10124-10128 114
- Church, S. L., Grant, J. W., Ridnour, L. A., Oberley, L. W., Swanson, P. E., Meltzer, P. S. and Trent, J. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 3113-3117 127
- Gardener, D. L., Fitzmaurice, R. L. and Stachan, M. (1995) Ann. Rheum. Dis., in the press 137
- Leanderson, P. and Tageson, C. (1993) in DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 293-314, Ellis Horwood, Chichester 159
- Fraga, C. G., Motchnik, P. A., Shigenaga, M. J. K., Helbock, H. J., Jacob, R. A. and Ames, B. N. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11003-11006 189
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Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms
Larsson, S. C., Kumlin, M., Ingelman-Sundberg, M., & Wolk, A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.935 · Cited by 950 · see citing works
Kakhlon, O., & Cabantchik, Z. I. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01006-7 · Cited by 839 · see citing works
Oxidative mechanism of arsenic toxicity and carcinogenesis
Shi, H., Shi, X., & Liu, K. J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007262.26044.e8 · Cited by 684 · see citing works
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
Lovell, M. A., & Markesbery, W. R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm821 · Cited by 515 · see citing works
The wanderings of a free radical
Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works
Self-citationInflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species
Azad, N., Rojanasakul, Y., & Vallyathan, V. (2008) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701436460 · Cited by 409 · see citing works
Complex cellular responses to reactive oxygen species
Temple, M. D., Perrone, G. G., & Dawes, I. W. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.04.003 · Cited by 398 · see citing works
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
Alves-Fernandes, D. K., & Jasiulionis, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133153 · Cited by 385 · see citing works
Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis?
Nair, S., Mason, A., Eason, J., Loss, G., & Perrillo, R. P. (2002) · Hepatology · doi:10.1053/jhep.2002.33713 · Cited by 348 · see citing works
Inflammation and the development of pancreatic cancer
Farrow, B., & Evers, B. M. (2002) · Surgical Oncology · doi:10.1016/s0960-7404(02)00015-4 · Cited by 338 · see citing works
Pope, W. B., Prins, R. M., Albert Thomas, M., Nagarajan, R., Yen, K. E., Bittinger, M. A., Salamon, N., Chou, A. P., Yong, W. H., Soto, H., et al. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0737-8 · Cited by 318 · see citing works
The Role of the Microbiota in Inflammation, Carcinogenesis, and Cancer Therapy
Dzutsev, A., Goldszmid, R. S., Viaud, S., Zitvogel, L., & Trinchieri, G. (2015) · European Journal of Immunology · doi:10.1002/eji.201444972 · Cited by 300 · see citing works
Sallmyr, A., Fan, J., & Rassool, F. V. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.036 · Cited by 285 · see citing works
Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells
Lavrentieva, A., Majore, I., Kasper, C., & Hass, R. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-18 · Cited by 241 · see citing works
Chronic immune response dysregulation in MDS pathogenesis
Barreyro, L., Chlon, T. M., & Starczynowski, D. T. (2018) · Blood · doi:10.1182/blood-2018-03-784116 · Cited by 226 · see citing works
Rehman, A., Collis, C. S., Yang, M., Kelly, M., Diplock, A. T., Halliwell, B., & Rice-Evans, C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8592 · Cited by 202 · see citing works
Self-citationMitohormesis in exercise training
Merry, T. L., & Ristow, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.11.032 · Cited by 176 · see citing works
Oxidative and antioxidative mechanisms in oral cancer and precancer: A review
Choudhari, S. K., Chaudhary, M., Gadbail, A. R., Sharma, A., & Tekade, S. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2013.09.011 · Cited by 177 · see citing works
Role of UV Light in Photodamage, Skin Aging, and Skin Cancer: Importance of Photoprotection
Gonzaga, E. R. (2009) · American Journal of Clinical Dermatology · doi:10.2165/0128071-200910001-00004 · Cited by 156 · see citing works
Moura, D. J., Richter, M. F., Boeira, J. M., Pegas Henriques, J. A., & Saffi, J. (2007) · Mutagenesis · doi:10.1093/mutage/gem016 · Cited by 152 · see citing works
Abnormalities in nitric oxide and its derivatives in lung cancer
Masri, F. A., Comhair, S. A. A., Koeck, T., Xu, W., Janocha, A., Ghosh, S., Dweik, R. A., Golish, J., Kinter, M., Stuehr, D. J., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1523oc · Cited by 128 · see citing works
A Review on Microbiological Decontamination of Fresh Produce with Nonthermal Plasma
Pignata, C., D'Angelo, D., Fea, E., & Gilli, G. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13412 · Cited by 121 · see citing works
Sokolov, M. V., Dickey, J. S., Bonner, W. M., & Martin, O. A. (2007) · Cell Cycle · doi:10.4161/cc.6.18.4682 · Cited by 100 · see citing works
Asare, G. A., Mossanda, K. S., Kew, M. C., Paterson, A. C., Kahler-Venter, C. P., & Siziba, K. (2006) · Toxicology · doi:10.1016/j.tox.2005.11.006 · Cited by 98 · see citing works
Delinasios, G. J., Karbaschi, M., Cooke, M. S., & Young, A. R. (2018) · Scientific Reports · doi:10.1038/s41598-017-18924-4 · Cited by 95 · see citing works
DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Luo, G.-Z., & He, C. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3412 · Cited by 87 · see citing works
Hyperinsulinemia: A unifying theory of chronic disease?
Crofts, C. A. P. (2015) · Diabesity · doi:10.15562/diabesity.2015.19 · Cited by 75 · see citing works
Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R. (2016) · Molecules · doi:10.3390/molecules21111442 · Cited by 60 · see citing works
DNA−Protein Cross-Linking from Oxidation of Guanine via the Flash−Quench Technique
Nguyen, K. L., Steryo, M., Kurbanyan, K., Nowitzki, K. M., Butterfield, S. M., Ward, S. R., & Stemp, E. D. A. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993502p · Cited by 59 · see citing works
DNA−Protein Cross-Linking via Guanine Oxidation: Dependence upon Protein and Photosensitizer
Kurbanyan, K., Nguyen, K. L., To, P., Rivas, E. V., Lueras, A. M. K., Kosinski, C., Steryo, M., González, A., Mah, D. A., & Stemp, E. D. A. (2003) · Biochemistry · doi:10.1021/bi020713p · Cited by 53 · see citing works
Rolfsmeier, M. L., Laughery, M. F., & Haseltine, C. A. (2010) · Journal of Bacteriology · doi:10.1128/jb.00667-10 · Cited by 42 · see citing works
Butzer, U., Weidenbach, H., Gansauge, S., Gansauge, F., Beger, H. G., & Nussler, A. K. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00139-8 · Cited by 40 · see citing works
Perinatal exposure to nicotine and implications for subsequent obstructive lung disease
Maritz, G. S. (2013) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2012.03.006 · Cited by 37 · see citing works
Favrot, C., Beal, D., Blouin, E., Leccia, M. T., Roussel, A. M., & Rachidi, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5895439 · Cited by 36 · see citing works
Inflammatory Events During Murine Squamous Cell Carcinoma Development
Gasparoto, T. H., de Oliveira, C. E., de Freitas, L. T., Pinheiro, C. R., Ramos, R. N., da Silva, A. L., Garlet, G. P., da Silva, J. S., & Campanelli, A. P. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-46 · Cited by 35 · see citing works
Wan, J., Bae, M.-A., & Song, B.-J. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.10 · Cited by 32 · see citing works
Arihara, Y., Takada, K., Kamihara, Y., Hayasaka, N., Nakamura, H., Murase, K., Ikeda, H., Iyama, S., Sato, T., Miyanishi, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19508 · Cited by 28 · see citing works
- Authors
- WISEMAN, H., & HALLIWELL, B.
- Affiliations
- King's College London (GB)
- Corresponding author
- WISEMAN, Helen
- ORCID
- HALLIWELL, Barry
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1996-01-01
- Volume
- 313
- Issue
- 1
- Pages
- 17-29
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1216878
- OpenAlex
- W2164613158
- Cited by
- 2,345
- References
- 204
- Citations by year
- 2026: 18 · 2025: 37 · 2024: 42 · 2023: 36 · 2022: 56 · 2021: 70 · 2020: 77 · 2019: 95 · 2018: 111 · 2017: 132 · 2016: 107 · 2015: 129 · 2014: 129 · 2013: 124 · 2012: 120
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- DNA damage, reactive oxygen species, reactive nitrogen species, inflammatory diseases, tumor progression, oxidative stress, inflammation and carcinogenesis
- MeSH terms
- Animals, DNA, DNA Damage, Free Radicals, Humans, Inflammation, Neoplasms, Nitrogen Oxides, Reactive Oxygen Species, Disease Progression
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