The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice
Open accessAbstract
Key Points: Crbn I391V mice degrade known thalidomide derivative targets and recapitulate thalidomide-induced cytopenias and teratogenicity. Degradation of Ck1α is sufficient to explain the in vivo therapeutic window of lenalidomide in del(5q) myelodysplastic syndrome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In line with these findings, mice harboring a homozygous CRBN I391V knock-in allele, despite exhibiting degradation of mmIKZF1/3, mmZFP91, and mmCSNK1A1 Fink et al., 2018, show increased miscarriage upon IMiD treatment compared with control mice; however, they do not exhibit IMiD-induced embryopathies resembling the human phenotype Fink et al., 2018 .”
From Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) · cites this paper as Fink et al., 2018
Experimental — accuracy not yet measuredIn the citing paper
“Intriguingly, this site corresponds to position 391 in mouse Crbn, which features the critical isoleucine variant that is responsible for the lack of IMiD activity in mouse cells, hence masking the teratogenicity of thalidomide39.”
From Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders (2023) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thompson, A., Schäfer, J., Kuhn, K., Kienle, S., Schwarz, J., Schmidt, G., Neumann, T., & Hamon, C. (2003) · Analytical Chemistry · doi:10.1021/ac0262560 · Cited by 2,425
Identification of a Primary Target of Thalidomide Teratogenicity
Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., & Handa, H. (2010) · Science · doi:10.1126/science.1177319 · Cited by 2,136
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke, J., Udeshi, N. D., Narla, A., Grauman, P., Hurst, S. N., McConkey, M., Svinkina, T., Heckl, D., Comer, E., Li, X., et al. (2014) · Science · doi:10.1126/science.1244851 · Cited by 1,879
Self-citationThe Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
Lu, G., Middleton, R. E., Sun, H., Naniong, M., Ott, C. J., Mitsiades, C. S., Wong, K.-K., Bradner, J. E., & Kaelin, W. G. (2014) · Science · doi:10.1126/science.1244917 · Cited by 1,583
Lenalidomide in the Myelodysplastic Syndrome with Chromosome 5q Deletion
List, A., Dewald, G., Bennett, J., Giagounidis, A., Raza, A., Feldman, E., Powell, B., Greenberg, P., Thomas, D., Stone, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061292 · Cited by 1,319
Lenalidomide plus Dexamethasone for Relapsed Multiple Myeloma in North America
Weber, D. M., Chen, C., Niesvizky, R., Wang, M., Belch, A., Stadtmauer, E. A., Siegel, D., Borrello, I., Rajkumar, S. V., Chanan-Khan, A. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070596 · Cited by 1,233
Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple Myeloma
Attal, M., Lauwers-Cances, V., Marit, G., Caillot, D., Moreau, P., Facon, T., Stoppa, A. M., Hulin, C., Benboubker, L., Garderet, L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114138 · Cited by 1,155
Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma
McCarthy, P. L., Owzar, K., Hofmeister, C. C., Hurd, D. D., Hassoun, H., Richardson, P. G., Giralt, S., Stadtmauer, E. A., Weisdorf, D. J., Vij, R., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114083 · Cited by 1,147
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Fischer, E. S., Böhm, K., Lydeard, J. R., Yang, H., Stadler, M. B., Cavadini, S., Nagel, J., Serluca, F., Acker, V., Lingaraju, G. M., et al. (2014) · Nature · doi:10.1038/nature13527 · Cited by 1,141
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Ebert, B. L., Pretz, J. L., Bosco, J., Chang, C. Y., Tamayo, P., Galili, N., Raza, A., Root, D. E., Attar, E. C., Ellis, S. R., et al. (2008) · Nature · doi:10.1038/nature06494 · Cited by 953
Self-citation
Cited by
Sorted by citations
Items 101–131 of 131
Naruse, C., Ishibashi, O., Ohgushi, M., Imai, H., Matsuzaki, T., Pan, X., Miyazaki, T., Shidahara, Y., Shirakawa, Y., Sugiyama, F., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112992 · Cited by 1
Developmental toxicology profile of the IRAK4 degrader KT-474
Enerson, B. E., Cappon, G. D., Shi, Y., Walther, D. M., Campbell, V., Chen, D., Kuhn, E. W., Massa, V., Ho, C. M. W., Zheng, X., et al. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf170 · Cited by 1
Minnie, S. A., Ho, K., Boiko, J. R., Adams, R. C., Ensbey, K. S., Nemychenkov, N. S., Legg, S. R. W., Schmidt, C. R., Comstock, M., Lyons, J., et al. (2026) · Blood · doi:10.1182/blood.2025030207 · Cited by 1
Calescibetta, A. R., Dalton, R., Fortenbery, N. R., Ward, G., Christiansen, S., Chen, X., Cheng, P., Razabdouski, T. N., Glode, A. J., Tu, N., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0344471 · Cited by 1
Rodrigo-Brenni, M. C., Komen, J. C., Hamza, G. M., Bohin, N., Adomavicius, T., Andres, A., Blaho, S., Börjesson, U., Collie, G. W., Donatis, G. M. D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70663-1 · Cited by 3
Li, L., Ha, T., Feng, J., DiPrima, M., Wang, D. L., Jailwala, P., Meyer, T. J., Lack, J., Ohnuki, H., & Tosato, G. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08720-2 · Cited by 1
Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders
Lu, D., Yu, X., Lin, H., Cheng, R., Zhang, M., Yang, B., Chen, J., Li, F., Qi, X., & Wang, J. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01156 · Cited by 1
How to Transform an Exceptional Case Report Into a Therapy: Following the Frog Out of the Box
Heiblig, M., Alcazer, V., Pleșa, A., Labussière‐Wallet, H., & Sujobert, P. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000629 · Cited by 1
History of IMiDs and Protein Degradation as a Pharmacological Modality
Yamamoto, J., Asatsuma‐Okumura, T., Ito, T., Yamaguchi, Y., & Handa, H. (2022) · Wiley eBooks · doi:10.1002/9781119774198.ch8 · Cited by 1
Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
Tesio, M. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000827 · Cited by 1
Mice no longer immune to immunomodulatory drugs
Pichiorri, F. (2018) · Blood · doi:10.1182/blood-2018-08-868083
Udeshi, N. D., Mani, D. R., Satpathy, S., Fereshetian, S., Gasser, J. A., Svinkina, T., Ebert, B. L., Mertins, P., & Carr, S. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/785378
Self-citationNew Activities of CELMoDs, Cereblon E3 Ligase-modulating Drugs
Matyskiela, M. E., Clayton, T., Thompson, J. W., Carroll, C. W., Bateman, L. A., LeBrun, L. A., & Chamberlain, P. P. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160691-00094
9052 京都梅津長福寺境内の構成 (1) : 『大梅山長福禅寺全盛古大図』と塔頭の成立時期
伊藤, 毅. (1990) · 学術講演梗概集. F, 都市計画, 建築経済・住宅問題, 建築歴史・意匠
Age and Sex Differences in the Eμ-TCL1 Adoptive Transfer Mouse Model of CLL
Sharpe, C., Perry, E., Hertlein, E. K., Muthusamy, N., & Byrd, J. C. (2022) · Blood · doi:10.1182/blood-2022-162900
Data from The IKZF1–IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages
Mougiakakos, D., Bach, C., Böttcher, M., Beier, F., Röhner, L., Stoll, A., Rehli, M., Gebhard, C., Lischer, C., Eberhardt, M., et al. (2023) · doi:10.1158/2326-6066.c.6550200
SMALL-MOLECULE DEGRADERS OF IKAROS ZINC FINGER (IKZF) TRANSCRIPTION FACTORS
Holmberg‐Douglas, N., Shunatona, H. P., Kumi, G. K., & Purandare, A. V. (2023) · Medicinal chemistry reviews · doi:10.1021/mc-2023-vol58.ch10
Etxebeste, A. (2023) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · doi:10.15581/10171/69185
Targeted protein degradation using thalidomide and its derivatives
Yamanaka, S. (2024) · Translational and Regulatory Sciences · doi:10.33611/trs.2024-007
Naruse, C., Ishibashi, O., Ohgushi, M., Imai, H., Matsuzaki, T., Pan, X., Miyazaki, T., Shidahara, Y., Shirakawa, Y., Sugiyama, F., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5084570
Marquez, J. C., Park, N., Choi, J. H., Garcia, M. V. F., Flores, J., Nyamaa, B., Seol, J. E., Kim, H. K., Shin, M., Park, S. G., et al. (2025) · BMB Reports · doi:10.5483/bmbrep.2024-0130
Rodrigues, T. D. R., Azevedo, F. H. C., & da Silva, V. G. (2025) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v6i11.7047
Metabolism of new drug modalities research advances – 2025 year in review
Ma, B., Cheruzel, L., Cho, S., Hauri, S., Li, X., Liu, J., Rehm, K., Seneviratne, H. K., Seo, H., Shi, L., et al. (2026) · Drug Metabolism Reviews · doi:10.1080/03602532.2026.2663169
Targeted degradation of CBP/p300 by CBPD-409 exhibits robust anti-myeloma activity
Corradini, S., Maksimos, M., Azab, F., Arsalani, S., Nwarunma, E., Watt, G., Soutar, R. L., Powell, M., Henderson, R., Travers, J., et al. (2026) · Leukemia · doi:10.1038/s41375-026-03004-2
Genetic evidence supports that thalidomide should not be used therapeutically in dogs
Arendt, M. L., & Meadows, J. R. S. (2026) · Veterinary oncology. · doi:10.1186/s44356-026-00067-2
Targeting IKZF2 with molecular glue degraders for cancer immunotherapy
Huang, Y., Huang, S., & Liu, Y. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104820
A patenting perspective of IKZF2 molecular glue degraders (2020-present)
Zhang, X. (2026) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2026.2748593
Improving PROTAC-Mediated Degradation in Mouse Models: BRD9 as a Case Study
Strohmier, B. P., Quarshie, J. T., Raghuvanshi, R., Kaur, S., Conjelko, G. G., & Dykhuizen, E. C. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.6c00628
Targeting MYC through GSPT1 codegradation in blood cancers
Powell, J. A., & Pitson, S. M. (2026) · Blood · doi:10.1182/blood.2026035659
Metadata
- Authors
- Fink, E. C., McConkey, M., Adams, D. N., Haldar, S. D., Kennedy, J. A., Guirguis, A. A., Udeshi, N. D., Mani, D. R., Chen, M., Liddicoat, B., Svinkina, T., Nguyen, A. T., Carr, S. A., & Ebert, B. L.
- Affiliations
- Broad Institute (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-04
- Volume
- 132
- Issue
- 14
- Pages
- 1535-1544
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6172563
- OpenAlex
- W2886628870
- Cited by
- 131
- References
- 62
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 20 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 7 · 2018: 3
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Edward P. Evans Foundation
- Henry and Marilyn Taub Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL082945)
- National Cancer Institute (F30CA199988, P01CA108631, P50CA206963, P01CA066996)
- National Institute of General Medical Sciences (T32GM007753)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- thalidomide, lenalidomide, thalidomide derivatives, del(5q) myelodysplastic syndrome, teratogenicity, therapeutic window, E3 ubiquitin ligase
- MeSH terms
- Lenalidomide, Animals, Antineoplastic Agents, Disease Models, Animal, Female, Hematopoiesis, Male, Mice, Inbred C57BL, Myelodysplastic Syndromes, Nerve Tissue Proteins, Thalidomide, Point Mutation, Casein Kinase I, Adaptor Proteins, Signal Transducing, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review