The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia
Open accessAbstract
Patients with chronic lymphocytic leukemia (CLL) have an increased risk for severe COVID-19 disease and mortality. The goal of this study was to determine the efficacy of COVID-19 vaccine in patients with CLL. We evaluated humoral immune responses to the BNT162b2 messenger RNA (mRNA) COVID-19 vaccine in patients with CLL and compared responses with those obtained in age-matched healthy control subjects. Patients received 2 vaccine doses, 21 days apart, and antibody titers were measured by using the Elecsys Anti-SARS-CoV-2 S assay after administration of the second dose. In a total of 167 patients with CLL, the antibody response rate was 39.5%. A comparison between 52 patients with CLL and 52 sex- and aged-matched healthy control subjects revealed a significantly reduced response rate among patients (52% vs 100%, respectively; adjusted odds ratio, 0.010; 95% confidence interval, 0.001-0.162; P < .001). The response rate was highest in patients who obtained clinical remission after treatment (79.2%), followed by 55.2% in treatment-naive patients and 16.0% in patients under treatment at the time of vaccination. In patients treated with either Bruton’s tyrosine kinase inhibitors or venetoclax ± anti-CD20 antibody, response rates were considerably low (16.0% and 13.6%). None of the patients exposed to anti-CD20 antibodies <12 months before vaccination responded. In a multivariate analysis, the independent predictors of response were younger age, female sex, lack of currently active treatment, immunoglobulin G levels ≥550 mg/dL, and immunoglobulin M levels ≥40 mg/dL. In conclusion, antibody-mediated response to the BNT162b2 mRNA COVID-19 vaccine in patients with CLL is markedly impaired and affected by disease activity and treatment. This trial was registered at www.clinicaltrials.gov as #NCT04746092.
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Cites
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
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RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study
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Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis
Lee, A. R. Y. B., Wong, S. Y., Chai, L. Y. A., Lee, S. C., Lee, M. X., Muthiah, M. D., Tay, S. H., Teo, C. B., Tan, B. K. J., Chan, Y. H., et al. (2022) · BMJ · doi:10.1136/bmj-2021-068632 · Cited by 498
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
O’Brien, M. P., Forleo-Neto, E., Musser, B. J., Isa, F., Chan, K.-C., Sarkar, N., Bar, K. J., Barnabas, R. V., Barouch, D. H., Cohen, M. S., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2109682 · Cited by 447
Neutralizing Antibody Testing in Patients With Multiple Myeloma Following COVID-19 Vaccination
Terpos, E., Rajkumar, S. V., & Leung, N. (2022) · JAMA Oncology · doi:10.1001/jamaoncol.2021.5942 · Cited by 22
Niessen, F. A., Knol, M. J., Hahné, S. J. M., Bonten, M. J. M., & Bruijning-Verhagen, P. C. J. L. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.06.011 · Cited by 15
Metadata
- Authors
- Herishanu, Y., Avivi, I., Aharon, A., Shefer, G., Levi, S., Bronstein, Y., Morales, M., Ziv, T., Shorer Arbel, Y., Scarfò, L., Joffe, E., Perry, C., & Ghia, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2021-04-16
- Volume
- 137
- Issue
- 23
- Pages
- 3165-3173
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W3156866359
- Cited by
- 614
- References
- 33
- FWCI
- 63.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Herishanu, Y., Avivi, I., Aharon, A., Shefer, G., Levi, S., Bronstein, Y., Morales, M., Ziv, T., Shorer Arbel, Y., Scarfò, L., Joffe, E., Perry, C., & Ghia, P. (2021). Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia. Blood. https://doi.org/10.1182/blood.2021011568
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