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Cited by 86Platelet Disorders and TreatmentsExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms

The multifaceted role of platelets in mediating brain function

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Burnouf, Thierry, Walker, Tara L.·2022·Blood
DOI 10.1182/blood.2022015970PMC PMC9412009
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Abstract

Platelets, the small, anucleate blood cells that originate from megakaryocytes in the bone marrow, are typically associated with coagulation. However, it is now apparent that platelets are more multifaceted than originally thought, with their function extending beyond their traditional role in hemostasis to acting as important mediators of brain function. In this review, we outline the broad repertoire of platelet function in the central nervous system, focusing on the similarities between platelets and neurons. We also summarize the role that platelets play in the pathophysiology of various neurological diseases, with a particular focus on neuroinflammation and neurodegeneration. Finally, we highlight the exciting prospect of harnessing the unique features of the platelet proteome and extracellular vesicles, which are rich in neurotrophic, antioxidative, and antiinflammatory factors, for the development of novel neuroprotective and neuroregenerative interventions to treat various neurodegenerative and traumatic pathologies.

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Cited by

Sorted by citations

Authors
Burnouf, T., & Walker, T. L.
Affiliations
  • Taipei Medical University (TW)
  • The University of Queensland (AU)
Corresponding author
  • Burnouf, Thierry
  • Walker, Tara L.
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2022-08-25
Volume
140
Issue
8
Pages
815-827
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.2022015970
PMC
PMC9412009
OpenAlex
W4282927357
Cited by
86
References
10
Citations by year
2026: 22 · 2025: 25 · 2024: 21 · 2023: 16 · 2022: 2
FWCI
2.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Blood (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Wilson Foundation
  • Ministry of Science and Technology, Taiwan (MOST110-2314-B038-079)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
platelets, platelet function, central nervous system, neuroinflammation, neurodegeneration, platelet proteome, extracellular vesicles, neuroprotection, nerve regeneration, traumatic brain injury, neurological disorders
MeSH terms
Blood Platelets, Brain, Hemostasis

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