The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Liver as a Source of Extrarenal Erythropoietin Production
Open accessAbstract
Abstract Nephrectomized rats exposed to intense hypoxia produce sufficient erythropoietin (Ep) to detectably increase their plasma Ep titers. Extrarenal Ep production is no longer detectable if nephrectomized rats are also subjected to 80% hepatectomy prior to being made hypoxic at 0.465 atmos and is barely detectable but significantly lower than in nephrectomized rats when exposed to 0.435 atmos. These results suggest that the liver plays an important role in the production of extrarenal erythropoietin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, in adults, the liver retains its ability to produce EPO in response to moderate/severe hypoxia or to pharmacologic HIF activation. 23–25”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [23]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057
Role of the kidney in erythropoiesis
JACOBSON, L. O., GOLDWASSER, E., FRIED, W., & PLZAK, L. (1957) · Nature · doi:10.1038/179633a0 · Cited by 862
Studies on the Production of Erythropoietin by Isolated Perfused Organs
Kuratowska, Z., Lewartowski, B., & MICHALAK, E. (1961) · Blood · doi:10.1182/blood.v18.5.527.527 · Cited by 132
Presence of Plasma Erythropoietin in Hypoxic Rats with or without Kidney(s) and/or Spleen
MIRAND, E. A., & Prentice, T. C. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23390 · Cited by 91
DeGowin, R. L., LAVENDER, A. R., FORLAND, M., CHARLESTON, D., & GOTTSCHALK, A. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-6-913 · Cited by 74
Studies on extrarenal erythropoietin.
Fried, W. I., Kilbridge, T. M., Krantz, S. B., McDonald, T. P., & Lange, R. D. (1969) · PubMed · Cited by 61
A Possible Mechanism for the Erythrocytosis Associated with Hepatocellular Carcinoma in Man
Gordon, A. S., Zanjani, E. D., & Zalusky, R. (1970) · Blood · doi:10.1182/blood.v35.2.151.151 · Cited by 57
SCHOOLEY, J. C., & Mahlmann, L. J. (1972) · Blood · doi:10.1182/blood.v39.1.31.31 · Cited by 56
Jacobson, L., MARKS, E. K., GASTON, E. O., & Goldwasser, E. (1959) · Blood · doi:10.1182/blood.v14.6.635.635 · Cited by 54
USE OF THE HYPOXIA-INDUCED POLYCYTHEMIC MOUSE IN THE ASSAY AND STANDARDIZATION OF ERYTHROPOIETIN.
Weintraub, A. H., Gordon, A. S., & Camiscoli, J. F. (1963) · PubMed · Cited by 44
Cited by
Sorted by citations
Cloning and expression of the human erythropoietin gene.
Lin, F. K., Suggs, S. V., Lin, C.-W., Browne, J. K., Smalling, R., Egrie, J. C., Chen, K. K., Fox, G. M., Martin, F., & Stabinsky, Z. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7580 · Cited by 1,131
Isolation and characterization of genomic and cDNA clones of human erythropoietin
Jacobs, K. A., Shoemaker, C. B., Rudersdorf, R. A., Neill, S. D., Kaufman, R. J., Mufson, A., Seehra, J. S., Jones, S. S., Hewick, R. M., Fritsch, E. F., et al. (1985) · Nature · doi:10.1038/313806a0 · Cited by 1,077
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787
Effect of inflammatory cytokines on hypoxia-induced erythropoietin production
Wc, F., Schneider, T., & Goldberg, M. (1992) · Blood · doi:10.1182/blood.v79.8.1987.1987 · Cited by 522
Sasaki, H., Bothner, B. B., Dell, A., & Fukuda, M. N. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45317-3 · Cited by 484
Metadata
- Authors
- Fried, W.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Fried, Walter
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1972-11-01
- Volume
- 40
- Issue
- 5
- Pages
- 671-677
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W200215156
- Cited by
- 235
- References
- 18
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
- Keywords
- erythropoietin, liver, hepatectomy, hypoxia, nephrectomy, hypobaric hypoxia, plasma erythropoietin levels
- MeSH terms
- Adrenalectomy, Animals, Hypoxia, Castration, Erythropoiesis, Erythropoietin, Hepatectomy, Hydrocortisone, Liver, Nephrectomy, Polycythemia, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
