Cited by 235Erythropoietin and Anemia TreatmentHemoglobin structure and functionHigh Altitude and Hypoxia

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The Liver as a Source of Extrarenal Erythropoietin Production

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Fried, Walter·1972·Blood

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Abstract

Abstract Nephrectomized rats exposed to intense hypoxia produce sufficient erythropoietin (Ep) to detectably increase their plasma Ep titers. Extrarenal Ep production is no longer detectable if nephrectomized rats are also subjected to 80% hepatectomy prior to being made hypoxic at 0.465 atmos and is barely detectable but significantly lower than in nephrectomized rats when exposed to 0.435 atmos. These results suggest that the liver plays an important role in the production of extrarenal erythropoietin.

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Authors: Fried, W.
Affiliations: University of Illinois Chicago (US)
Corresponding author: Fried, Walter
Venue: Blood
Publisher: American Society of Hematology
Published: 1972-11-01
Volume: 40
Issue: 5
Pages: 671-677
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v40.5.671.671
OpenAlex: W200215156
Cited by: 235
References: 18
Citations by year: 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI: 3.87
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
Keywords: erythropoietin, liver, hepatectomy, hypoxia, nephrectomy, hypobaric hypoxia, plasma erythropoietin levels
MeSH terms: Adrenalectomy, Animals, Hypoxia, Castration, Erythropoiesis, Erythropoietin, Hepatectomy, Hydrocortisone, Liver, Nephrectomy, Polycythemia, Rats

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The Liver as a Source of Extrarenal Erythropoietin Production

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