The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Effects of oxygen tension and pH on the respiratory burst of human neutrophils
Open accessAbstract
The respiratory burst of human neutrophils was measured under conditions of hypoxia and low pH. O2 -- production by neutrophils activated with opsonized zymosan fell slowly as the oxygen concentration declined to 1%, then dropped more sharply, reaching negligible levels at oxygen concentrations less than 0.25%. Production was half maximal at an oxygen concentration of 0.35% (equivalent to approximately 10-microM dissolved oxygen). O2- production by the cell- free O2- -forming system prepared from zymosan-activated neutrophils showed a similar dependence on oxygen concentration. A drop in pH caused decreases in both oxygen consumption and O2-- production by zymosan-treated neutrophils, values at PH 6.0 being 10%--20% of those observed at pH 7.5. Experiments with the cell-free O2-- -forming system suggested that this decline in respiratory burst activity at low pH was due to inefficient activation of the O2-- -forming enzyme under acidic conditions.
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“Notably, the PMN oxidative burst is not hindered by even relatively low O2 (as low as 4.5% O2)8, which is important, since it means that ROS can be generated in the relatively low O2 environments of inflamed intestinal mucosa3.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [8]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Self-citationOxygen-Dependent Microbial Killing by Phagocytes
BABIOR, B. M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803232981205 · Cited by 2,483
Self-citationQuie, P. G., White, J. G., Holmes, B. M., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105568 · Cited by 910
Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.
Sj, K. (1975) · PubMed · Cited by 573
Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease
Curnutte, J. T., Whitten, D. M., & BABIOR, B. M. (1974) · New England Journal of Medicine · doi:10.1056/nejm197403142901104 · Cited by 364
Self-citationBABIOR, B. M., Curnutte, J. T., & McMurrich, B. J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108553 · Cited by 348
Self-citationBactericidal Activity of Aerobic and Anaerobic Polymorphonuclear Neutrophils
Mandell, G. L. (1974) · Infection and Immunity · doi:10.1128/iai.9.2.337-341.1974 · Cited by 331
McRipley, R. J., & Sbarra, A. J. (1967) · Journal of Bacteriology · doi:10.1128/jb.94.5.1425-1430.1967 · Cited by 208
Superoxide-forming enzyme from human neutrophils: Evidence for a flavin requirement
Babior, B., & Kipnes, R. (1977) · Blood · doi:10.1182/blood.v50.3.517.517 · Cited by 174
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
The role of reactive oxygen and antioxidant species in periodontal tissue destruction
Chapple, I., & Matthews, J. B. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00178.x · Cited by 962
Reactive Oxygen Species and Neutrophil Function
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Nox proteins in signal transduction
Brown, D., & Griendling, K. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 837
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Granger, D. N. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.6.h1269 · Cited by 818
Metadata
- Authors
- Gabig, T., Bearman, S., & Babior, B.
- Affiliations
- Tufts Medical Center (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1979-06-01
- Volume
- 53
- Issue
- 6
- Pages
- 1133-1139
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1501589213
- Cited by
- 190
- References
- 13
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 7
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- respiratory burst, neutrophils, hypoxia, oxygen partial pressure, low pH, superoxide production, zymosan, opsonized zymosan, NADPH oxidase, oxygen consumption, enzyme activation
- MeSH terms
- Hypoxia, Humans, Hydrogen-Ion Concentration, Neutrophils, Oxygen, Oxygen Consumption, Phagocytosis
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