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Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain
Open accessAbstract
Protein C activation by thrombin is significantly accelerated by the endothelial cell cofactor, thrombomodulin. In this study, we have developed a radioimmunoassay for thrombomodulin and have measured the cofactor content in several human tissues. The assay method detects as little as 2 ng of thrombomodulin. The highest thrombomodulin content was found in lung and placenta, but the antigen was also detected in spleen, pancreas, liver, kidney, skin, heart, and aorta. Unexpectedly, thrombomodulin was absent from brain. Extracts from cerebral cortex, cerebellum, centrum semiovale, midbrain, basal ganglia, pons, and medulla were devoid of thrombomodulin. In contrast, thrombomodulin antigen is present in extracerebral intracranial vessels, including basilar and internal carotid arteries and choroid plexus, as well as in endothelium of the pia-arachnoid.
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Citations
Cited by
Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,750
Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255690.03436.ae · Cited by 1,257
Esmon, C. T. (2003) · Chest · doi:10.1378/chest.124.3_suppl.26s · Cited by 719
The Regulation of Natural Anticoagulant Pathways
Esmon, C. T. (1987) · Science · doi:10.1126/science.3029867 · Cited by 697
Glycosaminoglycans and the regulation of blood coagulation
Bourin, M. C., & Lindahl, U. (1993) · Biochemical Journal · doi:10.1042/bj2890313 · Cited by 419
Metadata
- Authors
- Ishii, H., Salem, H., Bell, C., Laposata, E., & Majerus, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1986-02-01
- Volume
- 67
- Issue
- 2
- Pages
- 362-365
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1578269485
- Cited by
- 183
- References
- 0
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain. https://app.cochat.ai/papers/10.1182/blood.v67.2.362.362
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- Ishii, H., Salem, H., Bell, C., Laposata, E., & Majerus, P. (1986). Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain. Blood. https://doi.org/10.1182/blood.v67.2.362.362
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