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Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading
Open accessAbstract
A bleeding disorder with absent collagen-induced platelet aggregation and adhesion has been described in a patient whose platelets failed to express surface glycoprotein Ia. We studied the interaction of her platelets with subendothelium in an annular perfusion chamber and the interaction with purified human collagen type III in a rectangular perfusion system under flow conditions. Platelet adherence was almost completely absent both at low and high shear rates. The few platelets which adhered remained in the contact stage without subsequent spreading and aggregate formation. Addition of a monoclonal antibody, which was directed against the von Willebrand moiety of FVIII-VWF, to the blood, completely abolished platelet adherence at high shear rates and had a partial effect at low shear rates. These data indicate that von Willebrand factor plays a role in the initial attachment (contact stage) of platelets to subendothelium. We conclude that the bleeding disorder and excessively prolonged bleeding time in our patient are caused by a new specific defect of the platelet-vessel wall interaction.
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Citations
Cited by
Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion
Tandon, N. N., Kralisz, U., & Jamieson, G. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83273-2 · Cited by 489
Savage, B., Shattil, S. J., & Ruggeri, Z. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49910-9 · Cited by 314
The α2 Integrin Subunit-Deficient Mouse
Chen, J., Diacovo, T. G., Grenache, D. G., Santoro, S. A., & Zutter, M. M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64185-5 · Cited by 276
Saelman, E., Nieuwenhuis, H., Hese, K., de Groot, P., Heijnen, H., Sage, E., Williams, S., McKeown, L., Gralnick, H., & Sixma, J. (1994) · Blood · doi:10.1182/blood.v83.5.1244.1244 · Cited by 258
Self-citationMadamanchi, A., Santoro, S. A., & Zutter, M. M. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-017-9153-3_3 · Cited by 87
Metadata
- Authors
- Nieuwenhuis, H., Sakariassen, K., Houdijk, W., Nievelstein, P., & Sixma, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1986-09-01
- Volume
- 68
- Issue
- 3
- Pages
- 692-695
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2263309001
- Cited by
- 205
- References
- 0
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading. https://app.cochat.ai/papers/10.1182/blood.v68.3.692.692
- The paper
- Nieuwenhuis, H., Sakariassen, K., Houdijk, W., Nievelstein, P., & Sixma, J. (1986). Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading. Blood. https://doi.org/10.1182/blood.v68.3.692.692
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
