The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)
Abstract
Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. Under static conditions, platelet adhesion was observed to collagen types I through VII but not to type VIII. Under flow conditions, platelet adhesion to collagen types I, II, III, and IV was almost independent of shear rates above 300/s. Collagen type V was nonadhesive. Platelet adhesion to collagen type VI was shear rate-dependent and optimal at a rate of 300/s. Collagen types VII and VIII showed minor reactivity and supported platelet adhesion only between shear rates 100 to 1,000/s. Monoclonal antibody (MoAb) 176D7, directed against platelet membrane glycoprotein Ia (GPIa; very late antigen [VLA]-alpha 2 subunit), completely inhibited platelet adhesion to all collagens tested, under conditions of both stasis and flow. Platelet adhesion to collagen type III at shear rate 1,600/s was only inhibited for 85%. The concentration of antibody required for complete inhibition of platelet adhesion was dependent on the shear rate and the reactivity of the collagen. An MoAb directed against GPIIa (VLA-beta subunit) partially inhibited platelet adhesion to collagen. These results show that GPIa-IIa is a major and universal platelet receptor for eight unique types of collagen.
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Self-citationCHICK CARTILAGE COLLAGEN: A NEW TYPE OF α1 CHAIN NOT PRESENT IN BONE OR SKIN OF THE SPECIES
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Cited by
The collagen family members as cell adhesion proteins
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The role of collagen in thrombosis and hemostasis
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Self-citationRole of high shear rate in thrombosis
Casa, L. D. C., Deaton, D. H., & Ku, D. N. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2014.12.050 · Cited by 295
Functional Consequences of Integrin Gene Mutations in Mice
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Metadata
- Authors
- Saelman, E., Nieuwenhuis, H., Hese, K., de Groot, P., Heijnen, H., Sage, E., Williams, S., McKeown, L., Gralnick, H., & Sixma, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1994-03-01
- Volume
- 83
- Issue
- 5
- Pages
- 1244-1250
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1579822466
- Cited by
- 258
- References
- 20
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin). https://app.cochat.ai/papers/10.1182/blood.v83.5.1244.1244
- The paper
- Saelman, E., Nieuwenhuis, H., Hese, K., de Groot, P., Heijnen, H., Sage, E., Williams, S., McKeown, L., Gralnick, H., & Sixma, J. (1994). Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin). Blood. https://doi.org/10.1182/blood.v83.5.1244.1244
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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