The DOI matches its Crossref record.
Independent regulation of M-CSF and G-CSF gene expression in human monocytes
Abstract
The macrophage and granulocyte colony-stimulating factors, M-CSF and G- CSF, act in vitro to induce proliferation and differentiation of monocyte and granulocyte progenitor cells, respectively. We show here that both of these CSFs can be produced by stimulated human blood monocytes, but the M-CSF and G-CSF genes are independently regulated. Recombinant human interleukin-3 (IL-3) and GM-CSF primarily induce expression of the M-CSF gene and secretion of M-CSF, whereas bacterial lipopolysaccharide primarily induces expression of the G-CSF gene and secretion of G-CSF. These results suggest that under different conditions of in vitro stimulation the monocyte secretes factors that could lead selectively to either granulocyte or monocyte production.
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Citations
Cited by
Manz, M. G., & Boettcher, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3660 · Cited by 855
Groopman, J. E., Molina, J.-M., & Scadden, D. T. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911233212106 · Cited by 448
Levels of serum granulocyte colony-stimulating factor in patients with infections
Kawakami, M., Tsutsumi, H., Kumakawa, T., Abe, H., Hirai, M., Kurosawa, S., Mori, M., & Fukushima, M. (1990) · Blood · doi:10.1182/blood.v76.10.1962.1962 · Cited by 338
Metadata
- Authors
- Vellenga, E., Rambaldi, A., Ernst, T., Ostapovicz, D., & Griffin, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1988-06-01
- Volume
- 71
- Issue
- 6
- Pages
- 1529-1532
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W106626100
- Cited by
- 194
- References
- 0
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Independent regulation of M-CSF and G-CSF gene expression in human monocytes. https://app.cochat.ai/papers/10.1182/blood.v71.6.1529.1529
- The paper
- Vellenga, E., Rambaldi, A., Ernst, T., Ostapovicz, D., & Griffin, J. (1988). Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood. https://doi.org/10.1182/blood.v71.6.1529.1529
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