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Colony-stimulating factor-1 receptor
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The c-fms protooncogene maps near the CSF-1 locus on human chromosome 5 at
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“The M-CSF receptor is critical for monocytic cell survival, proliferation, and differentiation (3,13).”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [13]
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“One of the critical factors produced by stromal cells is macrophage colony-stimulating factor (M-CSF) (Stanley and Heard 1977; Rajavashistha et al. 1987; Sherr 1990; Hofstetter et al. 1992; Tanaka et al. 1993).”
BackgroundSchneider, A. H., Taira, T. M., Públio, G. A., Prado, D. D. S., Yabuta, P. B. D., dos Santos, J. C., Machado, C. C., de Souza, F. F. L., Venturini, L. G. R., de Oliveira, R. D. R., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16227 · Cited by 72
“M-CSF promotes the proliferation and survival of osteoclast precursors by binding to the c-Fms receptor (colony-stimulating factor 1 receptor ; Sherr, 1990).”
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“belonging to the class III receptor tyrosine kinase family [6].”
BackgroundGeneration and Characterization of MacGreen Mice, the Cfs1r-EGFP Transgenic Mice
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“This structure is common among the related family members, such as platelet-derived growth factor receptor (PDGFR), c-Kit, and c-Fms (Sherr 1990).”
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Interactions between neutrophils and endothelial cells
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“Many experiments have demonstrated that the macrophage colony-stimulating factor (colony-stimulating factor 1 [CSF-1]) is required for the differentiation, proliferation, and survival of monocytic phagocytes (20, 22).”
BackgroundCascade transactivation of growth factor receptors in early human hematopoiesis
Testa, U., Pelosi, E., Gabbianelli, M., Fossati, C., Campisi, S., Isacchi, G., & Peschle, C. (1993) · Blood · doi:10.1182/blood.v81.6.1442.1442 · Cited by 53
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“CSF-1R is a class III transmembrane tyrosine kinase receptor and its ligand CSF-1 has secreted glycoprotein, secreted proteoglycan and membrane-bound isoforms [3,4].”
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Molecular Genetic Aspects of Myelodysplastic Syndromes
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Myelodysplastic syndrome: review of the cytogenetic and molecular data
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“Studies showed that this gene does not possess a function of a TSG, but it could be localized very close to a TSG [14,15].”
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The colony stimulating factors
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Signalling through CSF receptors
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CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter
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“M-CSF has been shown to be a regulator of the growth, differentiation, and function of mononuclear phagocytes (Sherr, 1990).”
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Dominant-negative IκB Facilitates Apoptosis of Osteoclasts by Tumor Necrosis Factor-α
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“For their intracellular domain, seven tyrosine residues were well conserved between fish and mammal, another mammal conserved tyrosine residues Y708 were replaced by phenylalanine and arginine in EcMCSFR1 and EcMCSFR2 respectively [9,34,35].”
BackgroundSelective Expression of the Receptor Tyrosine Kinase, HTK, on Human Erythroid Progenitor Cells
Inada, T., Iwama, A., Sakano, S., Ohno, M., Sawada, K., & Suda, T. (1997) · Blood · doi:10.1182/blood.v89.8.2757 · Cited by 41
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“Previous studies have shown that BARF1 is a homologue of the human colony-stimulating factor-1 receptor (CSF-1R), the product of the proto-oncogene c-fms (27).”
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“It is encoded by the c-fms proto-oncogene and belongs to the class III receptor tyrosine kinase family.(5) CD115 overexpression has been reported in a wide variety of human tumors (notably breast, ovary, endometrium, Cancer progression has been associated with the presence of tumor-associated M2-macrophages (M2-tAMs)…”
BackgroundThromboxane synthase inhibitors and receptor antagonists
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Identification of a Novel Receptor Tyrosine Kinase Expressed in Acute Myeloid Leukemic Blasts
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“Point mutations in the ras and f in s genes are most frequently reported, which occur in up to 50% of MDS patients [5, 17-19, 21, 22, 28-30, 39, 44, 49, 57, 60, 68].”
BackgroundIn Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R
Knight, A. C., Varlow, C., Zi, T., Liang, S. H., Josephson, L., Schmidt, K. F., Patel, S., & Vasdev, N. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00802 · Cited by 37
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“Of interest in myeloid malignancies are members of Class III, including platelet-derived growth factor receptor (PDGFR), macrophage colony-stimulating factor (FMS-R or CSF-1R), stem cell factor receptor (KIT), and FMS-like tyrosine kinase 3 receptor (FLT3R).(57,58) The role of these receptors in leukemic transformatio…”
BackgroundAlternate Splicing Creates Two Forms of the Human Kit Protein
Zhu, W., Dong, W., & Minden, M. (1994) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199409073786 · Cited by 37
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Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1
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“CD115 (MCSFR) is the specific marker for monocytes and macrophages [29], whereas CD146 (MUC18) is specific to endothelial cells [30].”
BackgroundJohnson, D. E. (2007) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2007.11.002 · Cited by 33
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Chromosomal Deletions in Myelodysplasia
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Porcine Macrophage Markers and Populations: An Update
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“CD115, or CSF-1R, is a member of the family of type III growth factor receptors with tyrosine kinase activity, which controls the survival, proliferation, and differentiation of cells of the mononuclear phagocyte system [184,185].”
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Macrophage Lineage Switching of Murine Early Pre-B Lymphoid Cells Expressing Transduced fms Genes
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Self-citationThe receptors for regulatory molecules of hematopoiesis
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Colony stimulating factor-1 (CSF-1) in pregnancy
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THE 1993 LEWIS SCHIFFER MEMORIAL LECTURE TO THE CELL KINETICS SOCIETY
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RECEPTORS FOR COLONY‐STIMULATING FACTORS
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“Depending on their mechanism of action during hematopoietic differentiation, these factors can be classified into three categories: the first category includes growth factors that exert their action at the earliest stages of hematopoiesis, for example, the c-kit receptor ligand (KL) or stem cell factor (SCF) [45], FLT…”
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CELLULAR SIGNALLING PATHWAYS: NEW TARGETS IN LEUKAEMIA THERAPY
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Surface Antigens of Human Leukocytes
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“When M‐CSF binds to its cognate receptor c‐Fms (Sherr, 1990), it leads to the phosphorylation of specific tyrosine kinase residues present in the cytoplasmic tail of c‐Fms.”
BackgroundIncreased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease
Knight, A. C., Brill, S. A., Queen, S. E., Tarwater, P. M., & Mankowski, J. L. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx115 · Cited by 27
“CSF1R is expressed by microglia, including parenchymal microglia and perivascular macrophages (6, 8, 9).”
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Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors
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Unilineage hematopoietic differentiation in bulk and single cell culture
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“The glycine rich motif Gly-X-Gly-X-X-Gly (residues 597e602 in EcM-CSF) is conserved in teleost species [41], which is the characteristic structure of kinases associated with nucleotide binding in the membrane-proximal kinase segment.”
BackgroundERK1 Regulates the Hematopoietic Stem Cell Niches
Saulnier, N., Guihard, S., Holy, X., Décembre, É., Jurdic, P., Clay, D., Feuillet, V., Pagès, G., Pouysségur, J., Porteu, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030788 · Cited by 22
“This means that receptor synthesis is more likely to be governed by posttranscriptional regulation as previously suggested [47].”
ResultMicroRNA-125b inhibits AML cells differentiation by directly targeting Fes
Hu, J., Zheng, L., Shen, X., Zhang, Y., Cheng, L., & Xi, T. (2017) · Gene · doi:10.1016/j.gene.2017.04.002 · Cited by 21
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Adult acute myeloid leukaemia: update on treatment
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c-KIT expression enhances the leukemogenic potential of 32D cells.
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Clinical and Biological Analysis of Peripheral T-Cell Lymphomas: A Single Institution Study
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Metadata
- Authors
- Sherr, C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1990-01-01
- Volume
- 75
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2403681274
- Cited by
- 353
- References
- 0
- Citations by year
- 2024: 1 · 2023: 5 · 2022: 1 · 2021: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- American Lebanese Syrian Associated Charities (P30CA21765, CA 21765)
- National Institutes of Health (CA21765))
- National Cancer Institute (P 30CA 21765, P30CA021765)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- colony-stimulating factor 1 receptor, CSF1R, hematopoietic growth factor receptors, mesenchymal stem cells, osteoclastogenesis, receptor tyrosine kinase
- MeSH terms
- Cell Transformation, Neoplastic, Chromosomes, Human, Pair 5, Humans, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Receptors, Cell Surface, Signal Transduction, Down-Regulation, Receptor, Macrophage Colony-Stimulating Factor, Receptors, Platelet-Derived Growth Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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