Circulating erythropoietin levels after bone marrow transplantation: inappropriate response to anemia in allogeneic transplants
Open accessAbstract
We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic recovery. Observed Epo levels were compared with predicted levels based on the relationship between Epo and hematocrit in 125 control subjects. Circulating Epo levels were normal during conditioning and the early posttransplant period. Between days 21 and 180, Epo levels remained normal in ABMT patients but were inappropriately low for the degree of anemia in BMT patients. Median time to full erythropoietic engraftment was longer in BMT than in ABMT recipients. Circulating Epo returned to appropriate levels after day 180, except in patients with active cytomegalovirus infection. We conclude that impaired Epo response to anemia can contribute to delayed erythropoietic recovery after allogenic BMT. Renal toxicity of ciclosporin, interaction between host and donor marrow, and cytomegalovirus infection might play a role. This study could support the use of recombinant human Epo to accelerate erythropoietic engraftment after BMT.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Meta-analyses of randomized testosterone trials have reported very low frequency of neuro-occlusive events.
“The meta-analyses of randomized testosterone trials have, however, reported very low frequency of neuro-occlusive events (2,3,20).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Correction of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin
Eschbach, J. W., Egrie, J. C., Downing, M. R., Browne, J. K., & Adamson, J. W. (1987) · New England Journal of Medicine · doi:10.1056/nejm198701083160203 · Cited by 1,987 · see citing works
Winearls, C., Pippard, M. J., Downing, M. R., Oliver, D., Reid, C. D. L., & Cotes, P. M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92192-6 · Cited by 1,401 · see citing works
Radioimmunoassay of erythropoietin: circulating levels in normal and polycythemic human beings.
Garcia, J. F., Ebbe, S., Hollander, L., Cutting, H. O., Miller, M. E., & Cronkite, E. P. (1982) · PubMed · Cited by 192 · see citing works
Wingard, J. R., Dy, C., Burns, W. H., Fuller, D., Braine, H., Yeager, A., Kaiser, H. E., Burke, P., Graham, M., & Santos, G. (1988) · Blood · doi:10.1182/blood.v71.5.1432.1432 · Cited by 184 · see citing works
The in vivo metabolism of recombinant human erythropoietin in the rat
Spivak, J., & Hogans, B. (1989) · Blood · doi:10.1182/blood.v73.1.90.bloodjournal73190 · Cited by 179 · see citing works
Serum Erythropoietin Levels after Renal Transplantation
Sun, C. H., Ward, H., Paul, W. L., Koyle, M. A., Yanagawa, N., & Lee, D. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210304 · Cited by 154 · see citing works
The in vivo metabolism of recombinant human erythropoietin in the rat
Spivak, J., & Hogans, B. (1989) · Blood · doi:10.1182/blood.v73.1.90.90 · Cited by 152 · see citing works
SCHOOLEY, J. C., Kullgren, B., & ALLISON, A. C. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.tb02289.x · Cited by 144 · see citing works
Roodman, G. D., Bird, A., Hutzler, D. H., & Montgomery, W. (1987) · PubMed · Cited by 144 · see citing works
Determination of Serum Immunoreactive Erythropoietin in the Investigation of Erythrocytosis
Cotes, P. M., Doré, C. J., Yin, J. A. L., Lewis, S. M., Messinezy, M., Pearson, T. C., & Reid, C. D. L. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607313150503 · Cited by 127 · see citing works
Birgegård, G., WIDE, L. E., & Simonsson, B. (1989) · British Journal of Haematology · doi:10.1111/j.1365-2141.1989.tb07733.x · Cited by 92 · see citing works
Correction of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin
(1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170416 · Cited by 58 · see citing works
Clonogenic hemopoietic precursors in bone marrow transplantation
Messner, H., Curtis, J. E., Minden, M., Tritchler, D., Lockwood, G. A., Takahashi, T., Lépine, J., Jamal, N., Tweeddale, M., & Wandl, U. B. (1987) · Blood · doi:10.1182/blood.v70.5.1425.1425 · Cited by 52 · see citing works
Brown, S. A., Caro, J., Erslev, A. J., & Murray, T. G. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90367-8 · Cited by 49 · see citing works
Erythropoietin in health and disease
Eckardt, K., & Bauer, C. (1989) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1989.tb00205.x · Cited by 41 · see citing works
Ma, D. D. F., Varga, D. E., & Biggs, J. C. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.tb06127.x · Cited by 36 · see citing works
SCHOOLEY, J. C., Kullgren, B., & ALLISON, A. C. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.00011.x · Cited by 32 · see citing works
Vellenga, E., Sizoo, W., Hagenbeek, A., & Löwenberg, B. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.tb02255.x · Cited by 30 · see citing works
Lappin, T. R. J., Elder, G. E., Taylor, T., McMullin, M. F., & Bridges, J. M. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb02443.x · Cited by 28 · see citing works
Hemopoietic colony growth-promoting activities in the plasma of bone marrow transplant recipients.
Yamasaki, K., Solberg, L. A., Jamal, N., Lockwood, G. A., Tritchler, D., Curtis, J. E., Minden, M., Mann, K. G., & Messner, H. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113579 · Cited by 21 · see citing works
Wingard, J. R., Dy, C., Burns, W., et al. (1988) · Blood · doi:10.1182/blood.v71.5.1432.bloodjournal7151432 · Cited by 19 · see citing works
Serum erythropoietin levels after bone marrow transplantation.
Abedi, M. R., Bäckman, L., Boström, L., Lindbäck, B., & Ringdén, O. T. H. (1990) · PubMed · Cited by 13 · see citing works
The T-cell CD2 determinant mediates inhibition of erythropoiesis by the lymphokine cascade
Burdach, S. E. G., Shatsky, M., Wagenhorst, B. B., & Levitt, L. (1988) · Blood · doi:10.1182/blood.v72.2.770.770 · Cited by 10 · see citing works
The T-cell CD2 determinant mediates inhibition of erythropoiesis by the lymphokine cascade
Burdach, S. E. G., Shatsky, M., Wagenhorst, B., et al. (1988) · Blood · doi:10.1182/blood.v72.2.770.bloodjournal722770 · Cited by 5 · see citing works
Clonogenic hemopoietic precursors in bone marrow transplantation
Messner, H., Curtis, J. E., Minden, M., et al. (1987) · Blood · doi:10.1182/blood.v70.5.1425.bloodjournal7051425 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bachman, E., Travison, T. G., Basaria, S., Davda, M. N., Guo, W., Li, M., Connor Westfall, J., Bae, H., Gordeuk, V., & Bhasin, S. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt154 · Cited by 426 · see citing works
Use of Recombinant Human Erythropoietin Outside the Setting of Uremia
Cazzola, M., Mercuriali, F., & Brugnara, C. (1997) · Blood · doi:10.1182/blood.v89.12.4248 · Cited by 262 · see citing works
Cazzola, M., Ponchio, L., Beguin, Y. P., Rosti, V., Bergamaschi, G., Liberato, N., Fregoni, V., Nalli, G., Barosi, G., & Ascari, E. (1992) · Blood · doi:10.1182/blood.v79.1.29.29 · Cited by 134 · see citing works
Self-citationNEW TOOLS FOR CLINICAL EVALUATION OF ERYTHRON FUNCTION IN MAN
Cazzola, M., & Beguin, Y. P. (1992) · British Journal of Haematology · doi:10.1111/j.1365-2141.1992.tb08133.x · Cited by 117 · see citing works
Self-citationOn Radiation Damage to Normal Tissues and its Treatment: II. Anti-inflammatory drugs
Michalowski, A. S. (1994) · Acta Oncologica · doi:10.3109/02841869409098397 · Cited by 98 · see citing works
Rabinowitz, J., Petros, W., Stuart, A., & Peters, W. (1993) · Blood · doi:10.1182/blood.v81.9.2452.2452 · Cited by 90 · see citing works
A controlled trial of recombinant human erythropoietin after bone marrow transplantation
Link, H., Boogaerts, M., Fauser, A., Slavin, S., Reiffers, J. J., Gorin, N. C., Am, C., Mandelli, F., Burdach, S. E. G., & Ferrant, A. (1994) · Blood · doi:10.1182/blood.v84.10.3327.3327 · Cited by 81 · see citing works
CAIRO, M. S., Suen, Y., Sender, L. S., Gillan, E., Ho, W. G., Plunkett, J. M., & van de Ven, C. (1992) · Blood · doi:10.1182/blood.v79.7.1869.1869 · Cited by 69 · see citing works
Testa, U., Martucci, R., Rutella, S., Scambia, G., Sica, S., Panici, P. B., Pierelli, L., MENICHELLA, G., Leone, G. G. M., & Mancuso, S. (1994) · Blood · doi:10.1182/blood.v84.10.3532.3532 · Cited by 60 · see citing works
Prediction of response to optimize outcome of treatment with erythropoietin.
Beguin, Y. P. (1998) · PubMed · Cited by 58 · see citing works
Self-citationMacrophage function activating cytokines: potential clinical application
Nemunaitis, J. J. (1993) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(93)90022-v · Cited by 48 · see citing works
Paltiel, O., Cournoyer, D., & Rybka, W. B. (1993) · Transfusion · doi:10.1046/j.1537-2995.1993.33593255604.x · Cited by 41 · see citing works
Inhibition of erythropoietin production in vitro by human interferon gamma
Vannucchi, A. M., Grossi, A., Rafanelli, D., Statello, M., Cinotti, S., & Rossi-Ferrini, P. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04864.x · Cited by 40 · see citing works
Impaired erythropoietin production in mice treated with cyclosporin A
Vannucchi, A. M., Grossi, A., Bosi, A., Rafanelli, D., Guidi, S., Saccardi, R., Alterini, R., & Ferrini, P. R. (1991) · Blood · doi:10.1182/blood.v78.6.1615.1615 · Cited by 39 · see citing works
Beguin, Y. P., Maertens, J. A., Prijck, B. D., Schots, R., Seidel, L., Bonnet, C. M., Hafraoui, K., Willems, É., Vanstraelen, G., Servais, S., et al. (2013) · American Journal of Hematology · doi:10.1002/ajh.23552 · Cited by 36 · see citing works
“Elevated serum Epo levels are observed transiently after intensive conditioning regimens without concomitant changes in Hb [1,4,5].”
BackgroundSelf-citationJaspers, A., Baron, F., Willems, É., Seidel, L., Hafraoui, K., Vanstraelen, G., Bonnet, C. M., & Beguin, Y. P. (2014) · Blood · doi:10.1182/blood-2014-01-546333 · Cited by 33 · see citing works
Self-citationConcise Review: The Bone Marrow Niche as a Target of Graft Versus Host Disease
Bonin, M. V., & Bornhäuser, M. (2014) · Stem Cells · doi:10.1002/stem.1691 · Cited by 32 · see citing works
Ayash, L. J., ELIAS, A. D., Hunt, M., Demetri, G. D., Wheeler, C., Tepler, I., Schwartz, G. N., Mazanet, R., Reich, E., McCauley, M., et al. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04886.x · Cited by 32 · see citing works
Clinical use of hematopoietic growth factors in allogeneic bone marrow transplantation
Lazarus, H. M. (1994) · Blood Reviews · doi:10.1016/0268-960x(94)90078-v · Cited by 30 · see citing works
Baron, F., Sautois, B. R., Baudoux, É., Matus, G., Fillet, G., & Beguin, Y. P. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00795-6 · Cited by 30 · see citing works
Self-citationSerum erythropotietin and serum transferrin receptor levels in aplastic anaemia
Schrezenmeier, H., Noé, G., Raghavachar, A., Rich, I. N., Heimpel, H., & Kubanek, B. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb05020.x · Cited by 29 · see citing works
Effects of cyclosporin A on erythropoietin production by the human Hep3B hepatoma cell line
Vannucchi, A. M., Grossi, A., Bosi, A., Rafanelli, D., Statello, M., Guidi, S., Saccardi, R., & Rossi-Ferrini, P. (1993) · Blood · doi:10.1182/blood.v82.3.978.978 · Cited by 25 · see citing works
Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes
Stone, R. M., Bernstein, S. H., Demetri, G. D., Facklam, D., Arthur, K., Andersen, J., Aster, J. C., & Kufe, D. W. (1994) · Leukemia Research · doi:10.1016/0145-2126(94)90059-0 · Cited by 23 · see citing works
Beguin, Y. P., Baron, F., & Fillet, G. (1998) · PubMed · Cited by 20 · see citing works
Self-citationReid, T. J. A., Mullaney, M., Burrell, L. M., Redmond, J., & Mangan, K. F. (1994) · American Journal of Hematology · doi:10.1002/ajh.2830460109 · Cited by 19 · see citing works
Locatelli, F., Zecca, M., Beguin, Y. P., Giorgiani, G., Ponchio, L., Stefano, P. D., & Cazzola, M. (1993) · British Journal of Haematology · doi:10.1111/j.1365-2141.1993.tb03158.x · Cited by 19 · see citing works
Self-citationGayà, A., Urbano-Ispizúa, Á., Fernández‐Avilés, F., Salamero, O., Roncero, J. M., Rovira, M., Martı́nez, C., Talarn, C., Granell, M., Carreras, E., et al. (2008) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2008.05.008 · Cited by 18 · see citing works
Effect of recombinant human erythropoietin after allogeneic bone marrow transplantation
Link, H., Brune, T., Hübner, G., Diedrich, H., Freund, M., Stoll, M., Peest, D., Ebell, W., Bettoni, C., Oster, W., et al. (1993) · Annals of Hematology · doi:10.1007/bf01695863 · Cited by 18 · see citing works
“After BMT, mean EPO serum levels of 71-186 mU/ml were reported [ 1-3 , 10, 28], which compare favorably with our results in control patients.”
BackgroundResultMartelli, M., Ponchio, L., Beguin, Y. P., Meloni, G., Mandelli, F., & Cazzola, M. (1994) · PubMed · Cited by 18 · see citing works
Self-citationBaron, F., Frère, P., Fillet, G., & Beguin, Y. P. (2003) · PubMed · Cited by 17 · see citing works
Self-citationIvanov, V. V., Faucher, C., Mohty, M., Bilger, K., Ladaique, P., Sainty, D., Arnoulet, C., Chabannon, C., Vey, N., Camerlo, J., et al. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705152 · Cited by 17 · see citing works
Erythropoietin in stem cell transplantation
Miller, C., & Lazarus, H. M. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703022 · Cited by 17 · see citing works
The Role of Hematopoietic Growth Factors in Transfusion Medicine
Whitsett, C. (1995) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30109-6 · Cited by 16 · see citing works
Recombinant Human Erythropoietin Treatment of Anemia in Renal Transplant Patients
Ležaić, V., Lj, D., & Pavlović-Kentera, V. (1995) · Renal Failure · doi:10.3109/08860229509037638 · Cited by 17 · see citing works
Vannucchi, A. M., Bosi, A., Linari, S., Guidi, S., Longo, G., Lombardini, L., Mariani, M. P., Saccardi, R., Laszlò, D., & Ferrini, P. R. (1997) · PubMed · Cited by 17 · see citing works
Pirotte, M., Fillet, M., Seidel, L., Jaspers, A., Baron, F., & Beguin, Y. P. (2021) · American Journal of Hematology · doi:10.1002/ajh.26300 · Cited by 16 · see citing works
Self-citationBaron, F., Fillet, G., & Beguin, Y. P. (2002) · Transplantation · doi:10.1097/00007890-200212270-00008 · Cited by 16 · see citing works
Self-citationThe role of the blood bank in hematopoietic stem cell transplantation
Anderson, K. C. (1992) · Transfusion · doi:10.1046/j.1537-2995.1992.32392213814.x · Cited by 14 · see citing works
Changes in serum erythropoietin and the reticulocyte count during chemotherapy for leukemias
Sawabe, Y., Kikuno, K., Iseki, T., Iida, S., Tabata, Y., & Yonemitsu, H. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb01397.x · Cited by 14 · see citing works
Locatelli, F., Pedrazzoli, P., Barosi, G., Zecca, M., Porta, F., Liberato, L., Gambarana, D., Nespoli, L., & Cazzola, M. (1992) · British Journal of Haematology · doi:10.1111/j.1365-2141.1992.tb04571.x · Cited by 14 · see citing works
Clinical use of rHuEPO in bone marrow transplantation
Klaesson, S. (1999) · Medical Oncology · doi:10.1007/bf02787351 · Cited by 13 · see citing works
MONITORING OF ERYTHROPOIESIS BY THE SERUM TRANSFERRIN RECEPTOR AND ERYTHROPOIETIN
Fillet, G., & Beguin, Y. (2001) · Acta Clinica Belgica · doi:10.1179/acb.2001.024 · Cited by 12 · see citing works
Self-citationVanstraelen, G., Baron, F., Willems, É., Bonnet, C. M., Hafraoui, K., Frère, P., Fillet, G., & Beguin, Y. P. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.04.012 · Cited by 11 · see citing works
“The use of an unrelated donor increases the risk of infection as well as of acute GVHD, a complication associated with further inhibition of endogenous EPO production [16,17,43] and a cytokine storm potentially inhibiting marrow Table 4.”
BackgroundSelf-citationLocatelli, F., Porta, F., Zecca, M., Pedrazzoli, P., Maccario, R., Giani, S., Vitale, V., Martinetti, M., Mazzolari, E., Lanfranchi, A., et al. (1993) · American Journal of Hematology · doi:10.1002/ajh.2830420315 · Cited by 10 · see citing works
Lazarus, H. M. (1997) · Cancer treatment and research · doi:10.1007/978-1-4615-6349-5_12 · Cited by 7 · see citing works
Erythropoietin after Bone Marrow Transplantation
Miller, C. B., & Mills, S. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30142-4 · Cited by 7 · see citing works
Nielsen, O. J., Mandrup-Poulsen, T. R., Nerup, J., & CANADIAN‐EUR0PEAN RANDOMIZED CONTROL TRIAL GROUP (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb01001.x · Cited by 7 · see citing works
Therapie mit Erythropoetinen in der Onkologie
Link, H., & Bokemeyer, C. (2003) · Der Onkologe · doi:10.1007/s00761-003-0505-2 · Cited by 6 · see citing works
Fitzgerald, S. P., Beverborg, N. G., Beguin, Y. P., Artunç, F., Falhammar, H., & Bean, N. G. (2019) · Physiological Reports · doi:10.14814/phy2.14153 · Cited by 4 · see citing works
Self-citationTransfusions after nonmyeloablative or reduced-intensity conditioning regimens
Baron, F., Vanstraelen, G., & Beguin, Y. P. (2006) · Leukemia · doi:10.1038/sj.leu.2404431 · Cited by 5 · see citing works
Self-citationLow dose erythropoietin is effective in reducing transfusion requirements following allogeneic HSCT
Fox, C. P., Pacey, S. J., Das-Gupta, E. P., Russell, N. H., & Byrne, J. (2005) · Transfusion Medicine · doi:10.1111/j.1365-3148.2005.00623.x · Cited by 5 · see citing works
“This appropriate response to anaemia contrasts markedly with the Epo response observed after allogeneic haemopoietic stem cell transplantation (HSCT), where a prolonged period of inappropriately low endogenous Epo levels is seen (Beguin et al., 1991; Miller et al., 1992; Baron et al., 2003).”
BackgroundAnomalies in Circulating Erythropoietin Levels
Cotes, P. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb55709.x · Cited by 5 · see citing works
Biological Activities of Hematopoietic Growth Factors that Lead to Future Clinical Application
Nemunaitis, J. J. (1994) · Cancer Investigation · doi:10.3109/07357909409021412 · Cited by 5 · see citing works
Martino, M. V., Lanza, F., Demirer, T., Moscato, T., Secondino, S., & Pedrazzoli, P. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.971749 · Cited by 4 · see citing works
“The peak EPO levels are usually observed 1 week after transplantation, at the time of the nadir of erythropoietic activity [30,37,38].”
BackgroundPredictive factors for response of anemia to recombinant human erythropoietin
Beguin, Y. P. (2002) · Springer eBooks · doi:10.1007/978-3-7091-7658-0_15 · Cited by 4 · see citing works
Self-citationThe Use of Erythropoietin in the Treatment of Post-bone Marrow Transplatation Anemia
Vannucchi, A. M., Bosi, A., Grossi, A., Guidi, S., Saccardi, R., Bacci, P., Lombardini, L., & Rossi-Ferrini, P. (1993) · The International Journal of Artificial Organs · doi:10.1177/039139889301605s02 · Cited by 4 · see citing works
“In addition, most of the patients with active cytomegalovirus (CMV) infection or acute graft-versus-host disease (GVHD) show a further reduction of Epo levels (14,17).”
BackgroundČeponis, J., Wang, C., Swerdloff, R. S., & Liu, P. Y. (2017) · Endocrinology · doi:10.1007/978-3-319-29456-8_11-1 · Cited by 3 · see citing works
Čeponis, J., Wang, C., Swerdloff, R. S., & Liu, P. Y. (2017) · Endocrinology · doi:10.1007/978-3-319-44441-3_11 · Cited by 3 · see citing works
Matsuzaki, A., Nabholtz, J., Nahirniak, S., & Janowska‐Wieczorek, A. (1997) · Hematology · doi:10.1080/10245332.1997.11746331 · Cited by 3 · see citing works
Clinical Applications of Recombinant Human Erythropoietin
Spentzos, D., & Sytkowski, A. J. (2000) · Wiley eBooks · doi:10.1002/9783527613021.ch02 · Cited by 2 · see citing works
Prediction of response to rHuEpo
Beguin, Y. P. (2001) · ORBi (University of Liège) · Cited by 2 · see citing works
Self-citationPrediction of response to rhEPO in the anemia of cancer
Beguin, Y. P., & Straelen, G. V. (2008) · Springer eBooks · doi:10.1007/978-3-211-69459-6_21 · Cited by 1 · see citing works
Self-citationrhEPO in hematopoietic stem cell transplantation
Straelen, G. V., & Beguin, Y. P. (2008) · Springer eBooks · doi:10.1007/978-3-211-69459-6_22 · Cited by 1 · see citing works
Self-citationKing, K. E., & Ness, P. M. (1998) · Humana Press eBooks · doi:10.1007/978-1-4612-1798-5_12 · Cited by 1 · see citing works
Erythropoietin in Bone Marrow Transplantation: Pathophysiology and Clinical Use
Vannucchi, A. M., Grossi, A., Bosi, A., Rafanelli, D., Guidi, S., Saccardi, R., Longo, G., Miele, A., & Rossi-Ferrini, R. (1992) · Springer eBooks · doi:10.1007/978-3-642-77074-6_39 · Cited by 1 · see citing works
Marseglia, G. L., Marchi, A., Zecca, M., Pedrazzoli, P., & Locatelli, F. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83285-8 · Cited by 1 · see citing works
Recombinant Human Erythropoietin: Clinical Experience in Bone Marrow Transplantation
Bosi, A., Vannucchi, A. M., Grossi, A., Guidi, S., Saccardi, R., Bacci, P., Lombardini, L., & Ferrini, P. R. (1992) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199209058676 · Cited by 1 · see citing works
Cytokine Serum Levels During the Course of Acute Myeloid Leukemia
Stauch, M. B., Fritsche, D., & Höffken, K. (1997) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-60377-8_30
Érythropoïétine et greffe de cellules souches hématopoïétiques
Hunault, M., Schmidt, A., Lissandre, S., & Ifrah, N. (2006) · Hématologie
Biological response modifiers as adjuncts to stem cell transplantation
Shapira, M. Y., Resnick, I. B., Tsirigotis, P. D., & Slavin, S. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.5.467
“Erythropoietin (EPO) has been used on healthy marrow donors prior to marrow harvesting.”
BackgroundInfluentialBilgrami, S., Naqvi, B. H., Fox, J. M., Furlong, F. M., & Clive, J. M. (2001) · Journal of Pharmacy Technology · doi:10.1177/875512250101700205
Martino, M. V., Callea, I., Moscato, T., Pontari, A., Spiniello, E., & Fedele, R. (2012) · Open Journal of Blood Diseases · doi:10.4236/ojbd.2012.23012
“Elevated serum Epo levels are described after highdose chemotherapy without significantly changes in Hb [42-44].”
BackgroundPiccirillo, N., Sorà, F., Laurenti, L., Chiusolo, P., Serafini, R., Cicconi, S., Leone, G. G. M., & Sica, S. (2001) · American Journal of Hematology · doi:10.1002/ajh.10016
KEYNOTE ADDRESS Transfusions after nonmyeloablative or reduced-intensity conditioning regimens
Baron, F., Vanstraelen, G., & Beguin, Y. P. (2006)
Self-citationDevereux, S., & Pagliuca, A. (2004) · CRC Press eBooks · doi:10.1201/b14440-47
rhEPO in hematopoietic stem cell mobilization, transplantation and in-vitro expansion
Klaesson, S. (2002) · Springer eBooks · doi:10.1007/978-3-7091-7658-0_16
Čeponis, J., Wang, C., Swerdloff, R., & Liu, P. Y. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_11-2 · Cited by 1 · see citing works
Tang, B., Kim, G., Chen, T., & Tam, H. L. A. E. L. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1016149
- Authors
- Beguin, Y., Clemons, G., Oris, R., & Fillet, G.
- Affiliations
- University of Liège (BE)
- Department of Hematology, University of Liege, Belgium.
- ORCID
- Beguin, Y
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-02-15
- Volume
- 77
- Issue
- 4
- Pages
- 868-873
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1592476307
- Cited by
- 78
- References
- 20
- Citations by year
- 2026: 2 · 2021: 1 · 2019: 1 · 2017: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01hl022469-13)
- National Heart, Lung, and Blood Institute (HL 22469)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
- Keywords
- erythropoietin, bone marrow transplantation, anemia, allogeneic transplantation, autologous transplantation, cytomegalovirus infection, recombinant human erythropoietin
- MeSH terms
- Adolescent, Adult, Anemia, Child, Child, Preschool, Cytomegalovirus Infections, Erythropoietin, Female, Graft Survival, Graft vs Host Disease, Hematocrit, Hematologic Diseases, Humans, Male, Middle Aged, Transplantation, Autologous, Transplantation, Homologous, Bone Marrow Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
