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Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells
Abstract
The mechanism by which erythropoietin controls mammalian erythrocyte production is unknown. Labeling experiments in vitro with [ 3 H]thymidine demonstrated DNA cleavage in erythroid progenitor cells that was accompanied by DNA repair and synthesis. Erythropoietin reduced DNA cleavage by a factor of 2.6. In the absence of erythropoietin, erythroid progenitor cells accumulated DNA cleavage fragments characteristic of those found in programmed cell death (apoptosis) by 2 to 4 hours and began dying by 16 hours. In the presence of erythropoietin, the progenitor cells survived and differentiated into reticulocytes. Thus, apoptosis is a major component of normal erythropoiesis, and erythropoietin controls erythrocyte production by retarding DNA breakdown and preventing apoptosis in erythroid progenitor cells.
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Cited by
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Krantz, S. (1991) · Blood · doi:10.1182/blood.v77.3.419.419 · Cited by 855
Multiple extracellular signals are required for long-term oligodendrocyte survival
Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712
Programmed Cell Death in the Immune System
Cohen, J. J. (1991) · Advances in Immunology · doi:10.1016/s0065-2776(08)60822-6 · Cited by 560
Erythroblastic islands: niches for erythropoiesis
Chasis, J. A., & Mohandas, N. (2008) · Blood · doi:10.1182/blood-2008-03-077883 · Cited by 506
Metadata
- Authors
- Koury, M. J., & Bondurant, M. C.
- Venue
- Science
- Published
- 1990-04-20
- Volume
- 248
- Issue
- 4953
- Pages
- 378-381
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026452824
- Cited by
- 812
- References
- 0
- FWCI
- 27.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koury, M. J., & Bondurant, M. C. (1990). Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells. Science. https://doi.org/10.1126/science.2326648
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