The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
P53 gene mutations in acute myeloid leukemia with 17p monosomy
Open accessAbstract
We looked for mutations of exons 5 to 8 of the P53 gene in 10 patients with acute myeloid leukemia (AML) and 17p monosomy, and 36 patients with AML and no cytogenetic abnormalities of 17p. DNA was analyzed by polymerase chain reaction, single-strand conformation polymorphism analysis, and nucleotide sequencing. Four of the 10 patients with 17p monosomy showed point mutation, single-nucleotide deletion, or insertion in exons 7 or 8. By contrast, only 1 of the 36 patients with AML and no cytogenetic abnormalities of 17p showed a mutation of the P53 gene in exons 5 to 8 (P less than .01). These results suggest that alterations of the P53 gene may have a role in leukemogenesis in some cases of AML. The fact that P53 gene mutations occurred more often in patients with 17p monosomy seems to support the “recessive” model of tumor suppressive activity of the P53 gene rather than the “dominant” model, in which alteration of only one allele is sufficient for the development of malignancy.
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Citations
Cites
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Cited by
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
Cooperating gene mutations in acute myeloid leukemia: a review of the literature
Renneville, A., Roumier, C., Biggio, V, Nibourel, O., Boissel, N., Fenaux, P., & Preudhomme, C. (2008) · Leukemia · doi:10.1038/leu.2008.19 · Cited by 351
Self-citationChristiansen, D. H., Andersen, M. K., & Pedersen-Bjergaard, J. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.5.1405 · Cited by 308
Christiansen, D. H., Andersen, M. K., & Pedersen-Bjergaard, J. (2004) · Blood · doi:10.1182/blood-2004-02-0754 · Cited by 135
Metadata
- Authors
- Fenaux, P., Jonveaux, P., Quiquandon, I., Lai, J., Pignon, J., Loucheux-Lefebvre, M., Bauters, F., Berger, R., & Kerckaert, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-10-01
- Volume
- 78
- Issue
- 7
- Pages
- 1652-1657
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W80989898
- Cited by
- 175
- References
- 1
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fenaux, P., Jonveaux, P., Quiquandon, I., Lai, J., Pignon, J., Loucheux-Lefebvre, M., Bauters, F., Berger, R., & Kerckaert, J. (1991). P53 gene mutations in acute myeloid leukemia with 17p monosomy. Blood. https://doi.org/10.1182/blood.v78.7.1652.1652
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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