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Cited by 438

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]

Open access
Charache, S, Dover, GJ, Moore, RD, Eckert, S, Ballas, SK, Koshy, M, Milner, PF, Orringer, EP, Phillips, G Jr, Platt, OS·1992·Blood
DOI 10.1182/blood.v79.10.2555.2555
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Abstract

Patients with sickle cell anemia were treated with daily doses of hydroxyurea, to assess pharmacokinetics, toxicity, and increase in fetal hemoglobin (Hb) production in response to the drug. Plasma hydroxyurea clearances were not a useful guide to maximum tolerated doses of the drug. The mean daily single oral dose that could be maintained for at least 16 weeks was 21 mg/kg (range, 10 to 35 mg/kg). Among 32 patients, last HbF levels were 1.9% to 26.3% (mean, 14.9%) with increases in HbF over initial values of 1.4% to 20.2% (mean, 11.2%). The most significant predictors of last HbF were last plasma hydroxyurea level, initial white blood count and initial HbF concentration. Last HbF was not related to beta globin haplotype or alpha globin gene number. No serious toxicity was encountered. Clinically significant bone marrow depression was avoided, and chromosome abnormalities after 2 years of treatment were no greater than those observed before treatment. The period of observation has been too short to evaluate the risk of carcinogenesis. Patient's red cells developed striking macrocytosis. Median red cell Hb concentrations did not change. Hb concentrations increased, on average 1.2 g/dL, but serum erythropoietin levels increased. Patients' body weights increased, and some returned to work or school, but no conclusions regarding therapeutic efficacy could be drawn from this uncontrolled open-label study.

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Metadata

Authors
Charache, S., Dover, G., Moore, R., Eckert, S., Ballas, S., Koshy, M., Milner, P., Orringer, E., Phillips, G. J., & Platt, O.
Venue
Blood
Publisher
American Society of Hematology
Published
1992-05-15
Volume
79
Issue
10
Pages
2555-2565
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v79.10.2555.2555
OpenAlex
W3093093377
Cited by
438
References
33
FWCI
10.78
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]. https://app.cochat.ai/papers/10.1182/blood.v79.10.2555.2555
The paper
Charache, S., Dover, G., Moore, R., Eckert, S., Ballas, S., Koshy, M., Milner, P., Orringer, E., Phillips, G. J., & Platt, O. (1992). Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]. Blood. https://doi.org/10.1182/blood.v79.10.2555.2555

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.