The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.
Open accessAbstract
Increased production of fetal hemoglobin (HbF) was observed in a patient with sickle cell anemia treated with 5-azacytidine. Each of four courses of therapy resulted in a rapid and prolonged increase in the percentage of HbF containing reticulocytes (F reticulocytes) and HbF containing erythrocytes (F cells). The percentage of HbF in peripheral blood rose from 1.8 to 8.9%. The rise in HbF production was accompanied by an increase in peripheral blood hemoglobin concentration from 8 to 12 g/dl and an increase in mean erythrocyte volume. Treatment with 5-azacytidine resulted in hypomethylation of total genomic and a Y-chromosome-specific DNA fragment isolated from both peripheral blood and bone marrow. Of 15 restriction enzyme sites around the gamma-delta-beta-globin gene complex, only 2 became hypomethylated: one 107 bases 5' to the gamma G and the other 107 bases 5' to the gamma A globin genes.
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Citations
Cites
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831
5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia
Ley, T. J., DeSimone, J., Anagnou, N. P., Keller, G. H., Humphries, R. K., Turner, P. H., Young, N. S., Heller, P., & Nienhuis, A. W. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212093072401 · Cited by 490
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.
DeSimone, J., Heller, P., Hall, L., & Zwiers, D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4428 · Cited by 384
Individual variation in the production and survival of F cells in sickle-cell disease
Dover, G. J., Boyer, S. H., Charache, S., & Heintzelman, K. (1978) · New England Journal of Medicine · doi:10.1056/nejm197812282992603 · Cited by 144
Self-citation
Cited by
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]
Charache, S., Dover, G., Moore, R., Eckert, S., Ballas, S., Koshy, M., Milner, P., Orringer, E., Phillips, G. J., & Platt, O. (1992) · Blood · doi:10.1182/blood.v79.10.2555.2555 · Cited by 438
Self-citationHemoglobin S gelation and sickle cell disease
Eaton, W., & Hofrichter, J. (1987) · Blood · doi:10.1182/blood.v70.5.1245.1245 · Cited by 425
Approval Summary: Azacitidine for Treatment of Myelodysplastic Syndrome Subtypes
Kaminskas, E., Farrell, A., Abraham, S., Baird, A., Hsieh, L.-S., Lee, S.-L., Leighton, J. K., Patel, H., Rahman, A., Sridhara, R., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2135 · Cited by 423
Control of globin gene expression during development and erythroid differentiation
Stamatoyannopoulos, G. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.11.007 · Cited by 393
Metadata
- Authors
- Charache, S., Dover, G., Smith, K., Talbot, C. C., Moyer, M., & Boyer, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-08
- Volume
- 80
- Issue
- 15
- Pages
- 4842-4846
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053084472
- Cited by
- 275
- References
- 4
- FWCI
- 17.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex. https://app.cochat.ai/papers/10.1073/pnas.80.15.4842
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- Charache, S., Dover, G., Smith, K., Talbot, C. C., Moyer, M., & Boyer, S. (1983). Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.15.4842
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
