The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]
Open accessAbstract
P-glycoprotein (P-gp), the product of the MDR1 (multidrug resistance) gene, is a transmembrane efflux pump for different lipophilic compounds, including many anticancer drugs and fluorescent dyes. We have previously reported that the efflux of fluorescent dyes from lymphoid cells of human bone marrow was directly correlated with the cellular P-gp content. In the present study, we show that human peripheral blood lymphocytes (PBL) also express P-gp, and that P-gp expression correlates with the efflux of fluorescent dyes from PBL. This efflux was suppressed not only by chemical inhibitors of P-gp but also by a P-gp-specific monoclonal antibody UIC2, thus providing direct evidence that it was mediated by P-gp. We have also characterized dye efflux and UIC2 reactivity in specific PBL subsets. P-gp was expressed in the majority of CD56+, CD8+, and CD20+ lymphocytes, but in less than one half of CD4+ cells. P-gp-mediated dye efflux was highly heterogeneous relative to the expression of CD56RA, CD56RO, Leu-8, and HLA-DR antigens. No significant P-gp activity was detectable in CD14+ monocytes. MDR1 expression in normal lymphocytes may be a determinant of multidrug resistance in the corresponding malignancies.
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Expression of Multidrug Resistance Gene in Human Cancers
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Self-citationP-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma
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Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.
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Self-citationMolecular and Cellular Biology of Multidrug Resistance in Tumor Cells
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Use of fluorescent dyes as molecular probes for the study of multidrug resistance
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Metadata
- Authors
- Chaudhary, P., Mechetner, E., & Roninson, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1992-12-01
- Volume
- 80
- Issue
- 11
- Pages
- 2735-2739
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W25713858
- Cited by
- 379
- References
- 12
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]. https://app.cochat.ai/papers/10.1182/blood.v80.11.2735.2735
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- Chaudhary, P., Mechetner, E., & Roninson, I. (1992). Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]. Blood. https://doi.org/10.1182/blood.v80.11.2735.2735
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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