The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia
Open accessAbstract
A striking association between hepatitis C virus (HCV) infection and mixed cryoglobulinemia (MC) has been shown; thus, HCV seems to play an important etiopathogenetic role in this lymphoproliferative disorder. Because HCV is both a hepatotropic and lymphotropic virus, this study aimed to investigate the prevalence of HCV infection of peripheral blood mononuclear cells (PBMCs) in a series of 16 patients with type II (IgMk) MC. Antibodies against HCV were detected by commercially available kits (Second Generation Chiron enzyme-linked immunosorbent assay [ELISA] and recombinant-based immunoblot assay [RIBA]), and the presence of HCV RNA was evaluated in both sera and isolated PBMCs using the polymerase chain reaction technique. A previous exposure to HCV was shown by ELISA and confirmed by RIBA in all cases (100%). Moreover, HCV RNA was present in the sera of 8 of 16 patients (50%), whereas its frequency markedly increased (13 of 16 [81%]) when genomic sequences were detected in peripheral lymphocytes. HCV RNA was never detected in the PBMCs of 20 control subjects. These findings showed that HCV infection, alone or in combination with other factors, may be responsible for the clonal B-cell expansion underlying the systemic manifestations of MC, and may explain the appearance of a malignant non- Hodgkin's lymphoma in some subjects.
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Cites
Alter, H. J., Purcell, R. H., Shih, J. W., Melpolder, J. C., Houghton, M., Choo, Q.-L., & Kuo, G. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911303212202 · Cited by 1,658
Mixed cryoglobulinemia: Clinical aspects and long-term follow-up of 40 patients
Gorevic, P. D., Kassab, H. J., Levo, Y., Kohn, R., Meltzer, M., Prose, P., & Franklin, E. C. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90390-3 · Cited by 750
Evolution of tumours and the impact of molecular oncology
Klein, G., & Klein, E. (1985) · Nature · doi:10.1038/315190a0 · Cited by 661
Manns, M. P., Johnson, E. F., Griffin, K. J., Tan, E. M., & Sullivan, K. F. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113949 · Cited by 363
T-lymphocyte response to hepatitis C virus in different clinical courses of infection
Botarelli, P., Brunetto, M. R., Minutello, M. A., Calvo, P., Unutmaz, D., Weiner, A. J., Choo, Q.-L., Shuster, J. R., Kuo, G., Bonino, F., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90430-k · Cited by 313
Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity
Lenzi, M., Ballardini, G., Bianchi, F. B., Johnson, P. J., McFarlane, I. G., Smith, H. M., McFarlane, B. M., Bridger, C., Williams, R., & Vergani, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)90418-o · Cited by 200
Baker, A. (1993) · Hepatology · doi:10.1016/0270-9139(93)90374-v · Cited by 159
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Zignego, A. L., Ferri, C., Pileri, S. A., Caini, P., & Bianchi, F. B. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.06.008 · Cited by 262
Self-citationIkeda, M., Nozaki, A., Sugiyama, K., Tanaka, T., Naganuma, A., Tanaka, K., Sekihara, H., Shimotohno, K., Saito, M., & Kato, N. (2000) · Virus Research · doi:10.1016/s0168-1702(99)00121-5 · Cited by 149
Metadata
- Authors
- Ferri, C., Monti, M., La Civita, L., Longombardo, G., Greco, F., Pasero, G., Gentilini, P., Bombardieri, S., & Zignego, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-12-15
- Volume
- 82
- Issue
- 12
- Pages
- 3701-3704
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1594734615
- Cited by
- 291
- References
- 8
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Ferri, C., Monti, M., La Civita, L., Longombardo, G., Greco, F., Pasero, G., Gentilini, P., Bombardieri, S., & Zignego, A. (1993). Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood. https://doi.org/10.1182/blood.v82.12.3701.bloodjournal82123701
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
