The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells
Open accessAbstract
Previous studies have shown that the BCL-2 protooncogene encodes a mitochondrial protein that promotes cell survival by blocking programmed cell death. Bcl-2 protein has been detected in normal immature myeloid cells and in acute myeloid leukemia (AML) cells. To assess its functional role in normal and leukemic hematopoiesis, we performed serum-free cultures of CD34+ normal marrow cells, of bcl-2- positive myeloid lines, and of AML cells in the presence of bcl-2 sense, nonsense, and antisense phosphorothioate oligodeoxynucleotides. In all antisense-treated cultures, we observed (1) an inhibition of bcl- 2 protein expression by day 4 to 6 of culture; (2) a decrease in cell survival duration; and (3) a decrease in the number of clonogenic cells present in the culture. Moreover, exposure to chemotherapeutic drugs resulted in more effective killing of AML cells in the presence of antisense oligomers. We conclude that bcl-2 protein is necessary for the survival of myeloid cells in culture, and that it may be implicated in the resistance of AML cells to chemotherapy.
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Cites
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Reed, J. C. (1998) · Oncogene · doi:10.1038/sj.onc.1202591 · Cited by 1,049
Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
FADEEL, B., & ORRENIUS, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 698
Structure-Function Analysis of Bcl-2 Protein
Hanada, M., Aimé-Sempé, C., Sato, T., & Reed, J. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11962 · Cited by 419
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
Konopleva, M., Konoplev, S., Hu, W., Zaritskey, A., Afanasiev, B., & Andreeff, M. (2002) · Leukemia · doi:10.1038/sj.leu.2402608 · Cited by 389
BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance
Reed, J. C. (1995) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30104-7 · Cited by 316
Metadata
- Authors
- Campos, L., Sabido, O., Rouault, J., & Guyotat, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1994-07-15
- Volume
- 84
- Issue
- 2
- Pages
- 595-600
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2208136208
- Cited by
- 164
- References
- 2
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Campos, L., Sabido, O., Rouault, J., & Guyotat, D. (1994). Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells. Blood. https://doi.org/10.1182/blood.v84.2.595.595
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