Deciphering the plasma membrane hallmarks of apoptotic cells: Phosphatidylserine transverse redistribution and calcium entry
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BACKGROUND: During apoptosis, Ca2+-dependent events participate in the regulation of intracellular and morphological changes including phosphatidylserine exposure in the exoplasmic leaflet of the cell plasma membrane. The occurrence of phosphatidylserine at the surface of specialized cells, such as platelets, is also essential for the assembly of the enzyme complexes of the blood coagulation cascade, as demonstrated by hemorrhages in Scott syndrome, an extremely rare genetic deficiency of phosphatidylserine externalization, without other apparent pathophysiologic consequences. We have recently reported a reduced capacitative Ca2+ entry in Scott cells which may be part of the Scott phenotype. RESULTS: Taking advantage of these mutant lymphoblastoid B cells, we have studied the relationship between this mode of Ca2+ entry and phosphatidylserine redistribution during apoptosis. Ca2+ ionophore induced apoptosis in Scott but not in control cells. However, inhibition of store-operated Ca2+ channels led to caspase-independent DNA fragmentation and decrease of mitochondrial membrane potential in both control and Scott cells. Inhibition of cytochrome P450 also reduced capacitative Ca2+ entry and induced apoptosis at comparable extents in control and Scott cells. During the apoptotic process, both control and more markedly Scott cells externalized phosphatidylserine, but in the latter, this membrane feature was however dissociated from several other intracellular changes. CONCLUSIONS: The present results suggest that different mechanisms account for phosphatidylserine transmembrane migration in cells undergoing stimulation and programmed death. These observations testify to the plasticity of the plasma membrane remodeling process, allowing normal apoptosis even when less fundamental functions are defective.
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Actin-myosin interactions appear critical to formation of all four EV types, and phosphatidylserine translocation to the outer membrane is common to apoptotic bodies and microvesicles.
“For instance, actin-myosin interactions appear critical to the formation of all four types of EVs [66, 85, 100, 115].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [106]
The citation is attached to the sentence about actin–myosin interactions in the formation of all four EV types. Our copy’s Background and Results discuss calcium entry and phosphatidylserine externalization during apoptosis, but no passage found addresses actin–myosin interactions or formation of four EV types (searched: actin–myosin, actomyosin, myosin, and EV formation). (LLM, conf=0.75)
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Self-citationFlaskamp, L., Prechtl, M., Scheck, A., Hu, W., Ried, C., Kislinger, G., Simons, M., Krug, A., Kranich, J., & Brocker, T. (2025) · Advanced Science · doi:10.1002/advs.202507624 · Cited by 13 · see citing works
Kozian, D. H., Proulle, V., Nitsche, A., Galitzine, M., Martinez, M.-C., Schumann, B., Meyer, D., Herrmann, M., Freyssinet, J., & Kerbiriou‐Nabias, D. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-146 · Cited by 9 · see citing works
Self-citationExclusion of ABCA‐1 as a candidate gene for canine Scott syndrome
Brooks, M. B., Catalfamo, J. L., Etter, K.-S., Brisbin, A. G., & Bustamante, C. D. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03068.x · Cited by 8 · see citing works
Time Dependent Appearance of Selected Apoptotic Markers and Usefulness of Their Detection In vitro
Rudolf, E., & Červinka, M. (2002) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2019.70 · Cited by 3 · see citing works
A Complex Systems Perspective of Communication from Cells to Societies
Berea, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77961 · Cited by 4 · see citing works
Dervaux, T., Porro, C., Kunzelmann, C., Freyssinet, J., & Martínez, M. C. (2006) · Biochimie · doi:10.1016/j.biochi.2006.04.003 · Cited by 3 · see citing works
Self-citationMourdjeva, M., Popova, Z., Kyurkchiev, D. S., Kontinopoulou, K., Altankova, I., Kehayov, I. R., & Kyurkchiev, S. (2006) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00422.x · Cited by 3 · see citing works
Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_6 · Cited by 2 · see citing works
TTB2 induces apoptosis in Ewing sarcoma cells
Zou, X., & Huang, W. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6236 · Cited by 2 · see citing works
Михуткина, С. В., Salmina, A. B., Сычев, А. В., Uspenskaya, Y. A., Труфанова, Л. В., Taksanova, E. I., & Olovyannikova, R. Y. (2004) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000042709.57599.67 · Cited by 2 · see citing works
Scott Syndrome: More Than a Hereditary Defect of Plasma Membrane Remodeling
Toti, F., & Freyssinet, J. (2011) · doi:10.1002/9781118120118.ch16
Self-citationHaylett, R. S., & Rink, L. (2009) · RWTH Publications (RWTH Aachen)
Dependence of cellular behaviour on viscosity defined ligand mobility in supported lipid bilayers
Bennett, M. H. (2018) · Enlighten: Theses (The University of Glasgow)
Extracellular Vesicles: Living Prototypal Communication System
Brown, P. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82655
Yang, X., Yoshida, T., & Hanayama, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00151-6
- Authors
- Martínez, M. C., & Freyssinet, J.-M.
- Affiliations
- Université de Strasbourg (FR)
- Inserm (FR)
- Corresponding author
- Freyssinet, Jean-Marie
- ORCID
- Martínez, M Carmen
- Venue
- BMC Cell Biology
- Published
- 2001-10-17
- Volume
- 2
- Issue
- 1
- Pages
- 20-20
- ISSN
- 1471-2121 (ISSN-L)
- PMC
- PMC59679
- OpenAlex
- W2160975723
- Cited by
- 54
- References
- 55
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Cell Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- apoptosis, phosphatidylserine exposure, store-operated calcium entry, Scott syndrome, cytochrome P450, mitochondrial membrane potential, plasma membrane remodeling
- MeSH terms
- Calcimycin, Biological Transport, Calcium, Calcium Channel Blockers, Cell Line, Cell Membrane, Enzyme Inhibitors, Humans, Imidazoles, Ionophores, Membrane Potentials, Mitochondria, Phosphatidylserines, Proadifen, Calcium Channels, Apoptosis, DNA Fragmentation, Cytochrome P-450 Enzyme Inhibitors
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