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Cited by 371

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia

Inoue, Kazushi, Ogawa, Hiroyasu, Sonoda, Yoshiaki, Kimura, Takafumi, Sakabe, Hideaki, Oka, Yoshihiro, Miyake, Seigou, Tamaki, Hiroya, Oji, Yusuke, Yamagami, Tamotsu, Tatekawa, Toyoshi, Soma, Toshihiro, Kishimoto, Tadamitsu, Sugiyama, Haruo·1997·Blood
DOI 10.1182/blood.v89.4.1405
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Abstract

To clarify whether the expression of the WT1 gene in leukemic cells is aberrant or merely reflects that in normal counterparts, the expression levels of the WT1 gene were quantitated for normal hematopoietic progenitor cells. Bone marrow (BM) and umbilical cord blood (CB) cells were fluorescence-activated cell sorting (FACS)-sorted into CD34+ and CD34− cell populations, and the CD34+ cells into nine subsets (CD34+CD33−, CD34+CD33+, CD34+CD38−, CD34+CD38+, CD34+HLA-DR−, CD34+HLA-DR+, CD34+c-kithigh, CD34+c-kitlow, and CD34+c-kit−) according to the expression levels of CD34, CD33, CD38, HLA-DR, and c-kit. Moreover, acute myeloid leukemic cells were also FACS-sorted into four populations (CD34+CD33−, CD34+CD33+, CD34− CD33+, and CD34− CD33−). FACS-sorted normal hematopoietic progenitor and leukemic cells and FACS-unsorted leukemic cells were examined for the WT1 expression by quantitative reverse transcriptase-polymerase chain reaction. The WT1 expression in the CD34+ and CD34− cell populations and in the nine CD34+ subsets of BM and CB was at either very low (1.0 to 2.4 × 10−2) or undetectable (<10−2) levels (the WT1 expression level of K562 cells was defined as 1.0), whereas the average levels of WT1 expression in FACS-sorted and -unsorted leukemic cells were 2.4 to 9.3 × 10−1. Thus, the WT1 expression levels in normal hematopoietic progenitor cells were at least 10 times less than those in leukemic cells. Therefore, we could not find any normal counterparts of BM or CB that expressed the WT1 at levels comparable with those in leukemic cells. These results indicate an aberrant overexpression of the WT1 gene in leukemic cells and imply the involvement of this gene in human leukemogenesis.

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Metadata

Authors
Inoue, K., Ogawa, H., Sonoda, Y., Kimura, T., Sakabe, H., Oka, Y., Miyake, S., Tamaki, H., Oji, Y., Yamagami, T., Tatekawa, T., Soma, T., Kishimoto, T., & Sugiyama, H.
Venue
Blood
Publisher
American Society of Hematology
Published
1997-02-15
Volume
89
Issue
4
Pages
1405-1412
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v89.4.1405
OpenAlex
W2156593102
Cited by
371
References
31
FWCI
6.85
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia. https://app.cochat.ai/papers/10.1182/blood.v89.4.1405
The paper
Inoue, K., Ogawa, H., Sonoda, Y., Kimura, T., Sakabe, H., Oka, Y., Miyake, S., Tamaki, H., Oji, Y., Yamagami, T., Tatekawa, T., Soma, T., Kishimoto, T., & Sugiyama, H. (1997). Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia. Blood. https://doi.org/10.1182/blood.v89.4.1405

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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