The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide
Abstract
The Wilms tumor (WT1) gene has been reported to be preferentially expressed in acute leukemia cells, regardless of leukemia subtype and chronic myelogenous leukemia cells in blast crisis, but not in normal cells. This finding suggests strongly that WT1 protein is a potential target of immunotherapy for human leukemia. In this study, we established a CD8+ cytotoxic T-lymphocyte (CTL) clone directed against a WT1-derived peptide and examined its immunologic actions on leukemia cells. A CD8+ CTL clone, designated TAK-1, which lysed autologous cells loaded with a WT1-derived 9-mer peptide consisting of the HLA-A24 (HLA-A*2402)-binding motifs was established by stimulating CD8+ T lymphocytes from a healthy individual repeatedly with WT1 peptide-pulsed autologous dendritic cells. TAK-1 was cytotoxic to HLA-A24–positive leukemia cells expressing WT1, but not to HLA-A24–positive lymphoma cells that did not express WT1, HLA-A24–negative leukemia cells, or HLA-A24–positive normal cells. Treating leukemia cells with an antisense oligonucleotide complementary to the WT1 gene resulted in reduced TAK-1-mediated cytotoxicity, suggesting that target antigen of TAK-1 on leukemia cells is the naturally processed WT1 peptide in the context of HLA-A24. TAK-1 did not inhibit colony formation by normal bone marrow cells of HLA-A24–positive individuals. Because WT1 is overexpressed ubiquitously in various types of leukemia cells, but not in normal cells, immunotherapy using WT1 peptide-specific CTL clones should be an efficacious treatment for human leukemia. (Blood. 2000;95:286-293)
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Cites
Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells
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WT-1 is required for early kidney development
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The candidate Wilms' tumour gene is involved in genitourinary development
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Expression of the Wilms' tumor gene WT1 in the murine urogenital system.
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Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia
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Cited by
A listing of human tumor antigens recognized by T cells: March 2004 update
Novellino, L., Castelli, C., & Parmiani, G. (2005) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-004-0560-6 · Cited by 466
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Metadata
- Authors
- Ohminami, H., Yasukawa, M., & Fujita, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-01-01
- Volume
- 95
- Issue
- 1
- Pages
- 286-293
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W204705285
- Cited by
- 347
- References
- 38
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohminami, H., Yasukawa, M., & Fujita, S. (2000). HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood. https://doi.org/10.1182/blood.v95.1.286
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